Gene Editing for Cell Therapy
Dimitrios L. Wagner
Gene editing and synthetic biology: developing cell therapies for diseases with high unmet medical need.
Almost all bodily functions and their interaction are controlled and regulated by different cells of the immune system and their messenger substances. The aim of this clinical research field is to understand this interplay and its balance depending on age and disease, to make it diagnostically usable and to implement it in therapy concepts. This requires interdisciplinarity in basic research and the comprehensive use of modern technologies in order to understand how immune cells function in the context of inflammation, age-related and tumour-related matrix changes and in interaction with different biomaterials.
In addition, we develop immunological tools for the Centre's other research fields, including cell analysis and cell sorting methods as well as biomarkers for immune monitoring of regenerative therapies
Gene editing and synthetic biology: developing cell therapies for diseases with high unmet medical need.
The main function of the immune system is to protect against infection by pathogens such as viruses, bacteria and fungi. Functional defects of the immune system can lead to an increased incidence of certain infections. For example, patients with immunodeficiency often suffer from chronic viral, bacterial or fungal infections. In contrast, defects…