BIH Young Science

Eine Initiative von Nachwuchswissenschaftlerinnen und -wissenschaftlern aus MDC und Charité startete als BIH Young Science mit einer Gründungsveranstaltung im Januar 2014. Die Initiative verfolgt das Ziel, den regelmäßigen Austausch und die wissenschaftliche Diskussion insbesondere auf der Ebene der Nachwuchsgruppenleiterinnen und -leiter in der fächerübergreifenden, translationalen Forschung zu intensivieren. Mitglieder der Initiative sind Nachwuchswissenschaftlerinnen und -wissenschaftler von MDC und Charité.

Haben Sie Interesse, Mitglied von BIH Young Science zu werden? Dann bewerben Sie sich bitte hier!


Prof. Dr. med. Kai Schmidt-Ott

Department of Nephrology, Charité / Max Delbrück Center for Molecular Medicine

Robert-Rössle-Str. 10, 13125 Berlin

+49 30 9406 2512
kai.schmidt-ott@mdc-berlin.de

    Fields of Research

  • Kidney development and disease
  • Clinical and molecular nephrology
  • Acute kidney injury, kidney transplantation

Scientific Scope, Special Techniques, Translational Perspective

We study the molecular mechanisms of kidney development and kidney disease. We focus on the genetic and epigenetic mechanisms of transcriptional regulation. We conduct clinical and experimental studies to analyze the developing and diseased urogenital system both in patients and in experimental model systems. We apply a wide spectrum of molecular and cell biology techniques, mouse genetics, as well as systems biology and bioinformatics. Our translational goal is to develop novel personalized and disease-specific diagnostic and therapeutic approaches in nephrology, focusing on patients with acute kidney injury, kidney transplantation, and renal neoplasia.

University Education

1999 - 2000
Medical School, Free University of Berlin
1998 - 1999
Visiting Scholar, Department of Physiology, University of Florida (Prof. M. I. Phillips)
1992 - 1998
Medical School, Free University of Berlin

Professional Experience

2014 - now
Project leader DFG research unit 1368: “Therapeutic implications and pathophysiological role of calprotectin in acute kidney injury" (with Prof. Dr. T. Westhoff)
2014 - now
Project leader DFG research unit 1368: “Molecular physiology and epigenetics of NF-κB/BMP interactions in the post-ischemic kidney (with PD Dr. D. N. Müller and Dr. R. Schmidt-Ullrich)
2014 - now
Professorship of Urogenital Research at Charité - Universitätsmedizin Berlin and Max Delbrueck Center for Molecular Medicine
2012 - now
Attending physician, Department of Nephrology, Charité – Universitätsmedizin Berlin, Campus Mitte
2011 - 2013
Project leader DFG research unit 1368: " NF-κB and BMP signaling in acute kidney injury“ (with PD Dr. D. N. Müller und Dr. R. Schmidt-Ullrich)
2010 - 2012
Board certified physician in Internal Medicine, Department of Nephrology, Charité – Universitätsmedizin Berlin, Campus Mitte
2009 - 2013
Project leader, DFG research unit 667 “Epithelial mechanisms of renal volume regulation“
2009 - 2014
Junior Professor of Molecular Medicine, Charité – Universitätsmedizin Berlin
2008 - now
Adjunct Assistant Professor, Columbia University College of Physicians and Surgeons, New York, NY, USA
2007 - 2009
Clinical resident/nephrology fellow, Department of Nephrology and Hypertensiology (Prof. Dr. F. C. Luft), Charité – Universitätsmedizin Berlin, Campus Buch
2007 - 2013
Junior research group leader (Emmy Noether Program, Phase II) at the Max-Delbrück Center for Molecular Medicine, Berlin
2003 - 2007
Stipend of the German Research Foundation (Emmy Noether Program, Phase I, DFG), Postdoctoral Research Associate, Department of Medicine, Division of Nephrology, PI: Prof. Dr. Jonathan Barasch, Columbia University College of Physicians and Surgeons, New York
2001 - 2003
Clinical resident/nephrology fellow, Department of Nephrology and Hypertensiology (Prof. Dr. F. C. Luft), Charité – Universitätsmedizin Berlin, Campus Buch
1998 - 1999
Visiting Scholar (Gottfried Daimler and Carl Benz Foundation), Department of Physiology, Prof. Dr. M. I. Phillips, University of Florida
1996 - 2002
Medical dissertation, Department of Clinical Pharmacology and Toxicology, Freie Universität Berlin, Prof. Dr. Martin Paul, Title: “Endothelin-dependent morphological transformation of hypoxic astrocytes“ (summa cum laude)

Selected Awards, Honours, Scientific Achievements

2007
Emmy Noether stipend of the DFG (Phase II)
2003
Ernst Reuter Award of the Free University of Berlin (Best doctoral thesis of the year 2002)
2003
Emmy Noether stipend of the DFG (Phase I)

Selected Publications