BIH Young Science

Eine Initiative von Nachwuchswissenschaftlerinnen und -wissenschaftlern aus MDC und Charité startete als BIH Young Science mit einer Gründungsveranstaltung im Januar 2014. Die Initiative verfolgt das Ziel, den regelmäßigen Austausch und die wissenschaftliche Diskussion insbesondere auf der Ebene der Nachwuchsgruppenleiterinnen und -leiter in der fächerübergreifenden, translationalen Forschung zu intensivieren. Mitglieder der Initiative sind Nachwuchswissenschaftlerinnen und -wissenschaftler von MDC und Charité.

Haben Sie Interesse, Mitglied von BIH Young Science zu werden? Dann bewerben Sie sich bitte hier!


Prof. Dr. med. Antje Beling (geb. Voigt)

Charité - Institute for Biochemistry / Deutsches Zentrum für Herz-Kreislauf-Forschung

Charitéplatz 1, 10117 Berlin

+49 30 450 528 187
antje.beling@charite.de

    Fields of Research

  • Myocarditis / Inflammatory cardiomyopathy
  • Post-translational Modification with ISG15
  • Proteostasis / Ubiquitin-Proteasome System
  • Cardiotropic enteroviruses

Scientific Scope, Special Techniques, Translational Perspective

My mission is to decipher cell-intrinsic immune mechanisms that on the one hand limit pathogen spread during viral infection and on the other hand ensure immune homeostasis for the benefit of the host. We seek to use of evolutionary evolved endogenous effector pathways to fight susceptibility to infection. We address the biological control of infection through harnessing mediators of innate immunity and test them for their potential to reverse host susceptibility to intractable infection.

We are particulary interested in understanding the spatio-temporal regulation of immune responses that are needed for successful pathogen clearance during infection. A dysbalance within the precise timing e.g. of an antiviral immune responses can provoke deleterious disease progression. An excellent example for such a failure to regulate inflammatory processes during viral infection is myocarditis, which is an inflammation of the heart muscle with fulminant dysfunction of the heart muscle at acute stages and a potential development of long-term inflammation leading to chronic heart failure. We investigate two host key systems – the ISG15 and the ubiquitin-proteasome system – that are both needed to preserve immune homeostasis during viral infection, thereby (i) efficiently counteracting viral pathology and (ii) attenuating detrimental immune responses.

ISG15/ISGylation: Interferons α and β (IFN-α/β) are crucial effectors of the innate immune system. Engagement of the IFNA-receptor induces the expression of the IFN Stimulated Gene of 15 kDa (ISG15). We demonstrated that ISG15-dependent remodelling of the intracellular proteome plays a key role in constraining pathogen spread during enterovirus infection. Our group aims to dissect the role of ISG15 to regulate inflammatory processes during the course of viral infection. We are investigating the molecular mechanisms underlying the antiviral properties of the ISG15 system particularly during enterovirus infection. Thereby, proof-of-concept experiments are being conducted that study the therapeutic potential of the ISG15 system during viral infection. Such research represents an essential step towards the identification of novel drug targets in the future.

Ubiquitination/proteasome: During acute viral infection, IFN-α/β and pro-inflammatory cytokines induce the transcription of hundreds of genes, which on the other hand challenges proteolytic systems to ensure protein homeostasis. Our group investigates the function of the major intracellular proteolysis system, which is the ubiquitin-proteasome system (UPS) to regulate the immune response for the benefit of the host during viral infection. Beyond the generation of MHC class I restricted antigenic peptides, we are studying UPS function in the control of (i) viral replication, (ii) cytokine production, (iii) immune cell differentiation and survival, and (iv) preservation of cell vitality. We aim for a better understanding of the function of cytokine-inducible components of the UPS in different cell types, tissues and hosts to provide molecular aspects for novel treatment strategies of viral infection particulary for susceptible individuals.

Webpage: http://biochemie.charite.de/forschung/kardiale_infektionsbiologie_und_immunologie/

University Education

2012
Habilitation „The Impact of the Immunoproteasome in the Pathogenesis of murine CoxsackievirusB3-myocarditis“, Charité University Medical Centre in Berlin (Germany), Medical Section for Cardiology, Prof. Dr. Gert Baumann
2004
Dissertation: “Processing of the pp89 MCMV MHC Class I Epitope by the Proteasome” (summa cum laude), Institute of Biochemistry, Charité Berlin; Prof. Dr. rer. nat. Peter-M. Kloetzel
1996 - 2003
Human medicine: Humboldt University in Berlin (Germany), University of Bern and Zürich (Switzerland), University Hospital Birmingham (United Kingdom), University of Pittsburgh’s Medical School (U.S.A.)

Professional Experience

2015
Appointment W2-professorship in “Cardiac immunobiology and proteostasis” at the Institute for Biochemistry at the Charité Universitätsmedizin Berlin
2014
Board Certification in Cardiology
2012 - now
Research Group Leader: “Cardiac Immunmodulation”, Charité Berlin (Germany) – Charité Centre for Basic Sciences Berlin, Institute for Biochemistry, Prof. Dr. rer. nat. Britta Eickholt Other affiliations: Interdisciplinary Center for Infection Biology and Immunity (ZIBI) and faculty member of the International Max Planck Research School for Infectious Diseases and Immunology (IMPRS-IDI) - ZIBI Graduate School | German Centre for Cardiovascular Research | Berlin Institute of Health Young Science | Research Centre for Immune Sciences Charité Universitätsmedizin Berlin
2009 - 2012
Postdoctoral Fellow, Molecular Cardiology, Charité Berlin
2009
Board Certification in Internal Medicine
2004 - 2012
Charité University Medical Centre in Berlin, Medical Section for Cardiology
2003 - 2004
Research Fellow in Molecular Cardiology, Charité Berlin

Selected Awards, Honours, Scientific Achievements

2015
Klaus-Georg-und-Sigrid-Hengstberger Research Award
2014
Peter Hans Hofschneider Endowed Professorship for Molecular Medicine – Foundation for Experimental Biomedicine Zürich (Switzerland)
2013
Ingrid-zu-Solms Wissenschaftspreis Medizin, Frankfurt/Main
2009
Rudolf-Thauer-Poster Prize Awarded by the German Society of Cardiology
2008
Rahel-Hirsch-Scholarship - Charité Berlin

Selected Publications