BIH Young Science

Eine Initiative von Nachwuchswissenschaftlerinnen und -wissenschaftlern aus MDC und Charité startete als BIH Young Science mit einer Gründungsveranstaltung im Januar 2014. Die Initiative verfolgt das Ziel, den regelmäßigen Austausch und die wissenschaftliche Diskussion insbesondere auf der Ebene der Nachwuchsgruppenleiterinnen und -leiter in der fächerübergreifenden, translationalen Forschung zu intensivieren. Mitglieder der Initiative sind Nachwuchswissenschaftlerinnen und -wissenschaftler von MDC und Charité.

Haben Sie Interesse, Mitglied von BIH Young Science zu werden?  Dann bewerben Sie sich bitte hier!

Dr. rer. nat. Chotima Böttcher

Neuropsychiatry and Laboratory of Molecular Psychiatry, Department of Psychiatry and Psychotherapy

Chariteplatz 1, 10117 Berlin

+49 30 4505 17154

    Fields of Research

  • Cell Therapy
  • Myeloid cells
  • Neurodegenerative disorders

Scientific Scope, Special Techniques, Translational Perspective

My research focuses on
1) the differential roles of myeloid cells and microglia in neuropsychiatric disorders, including Huntington’s disease (HD), stroke, amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration/amyotrophic lateral sclerosis (FTLD/ALS);

2) the development of hematopoietic cells as tools to treat neurological disorders. Our proof-of-concept experiments in mice suggested that adoptive transfer of hematopoietic precursors (HPs) in non-conditioned SOD1G93A transgenic mice, a model of ALS, at the symptomatic phase resulted in delay of disease progression, extension of lifespan, improvement of motor activity, and attenuation of inflammatory pathology. Therefore, HPs are a promising cell population for the treatment of neurodegenerative disorders. We intend to translate our findings to the human condition using CD34+ enriched samples. The therapeutic potential of the identified human HPs will be evaluated in mouse models of neurodegenerative disorders such as ALS and HD by xenotransplantation.

University Education

2001 - 2005
Graduate studies (Dr. rer. nat.) in Pharmacy at Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany (summa cum laude, PhD-Scholarship from the German Academic Exchange Service, DAAD)
1997 - 2000
Master of Science in Pharmacy at Chulalongkorn University, Thailand
1992 - 1997
Bachelor of Science in Pharmacy at Prince of Songkla University, Thailand

Professional Experience

2006 - now
Senior postdoctoral fellow, Laboratory of Molecular Psychiatry, Charité - Universitätsmedizin Berlin
Postdoctoral fellow at Donald Danforth Plant Science Center, St. Louis, Missouri, USA
2005 - 2006
Postdoctoral fellow at Biocenter, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany
2000 - 2001
Lecturer at Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Ubonrathani University, Thailand

Selected Awards, Honours, Scientific Achievements

Dorothea-Erxleben-Preis for the year’s best Ph.D. thesis of Martin Luther University Halle-Wittenberg, Halle/Saale, Germany and Luther-Urkunde for the most excellent Ph.D. thesis