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Prof. Dr. rer. nat. Jeanette Erdmann

BIH Lecture Part 1: "From GWAS to novel treatment targets. Sex does matter in coronary artery disease."

Genome-wide association studies (GWAS) have identified over 300 loci associated with susceptibility to CAD. Consistent with other complex diseases, genetic discovery analyses in CAD have enabled insights into disease etiology and causal risk factors, facilitated the development of novel tools for predicting clinical risk, and identified novel therapeutic targets. The largest CAD meta-analysis to date, performed by Jeanette Erdmann and collaborators, identified the first associations that differed by sex. For none of these loci a causal link between SNP and specific genes have been established yet. Furthermore, there are no data that can explain the sex-specific effects of these loci.

About the Speaker

Jeanette Erdmann is a DZHK Professor and Director of the Institute for Cardiogenetics at the University of Lübeck, Germany. Honoring her achievements in the cardiovascular genetics field for the last 15 years she was elected as a member of the German National Academy of Sciences in 2021. The current 25 members of the Institute’s team are working towards a better understanding of the genetic causes of cardiovascular disease, especially coronary artery disease and myocardial infarction, using methods from bioinformatics and genetic epidemiology as well as cell and animal models. In 2017, she established a research group at the Institute of Cardiogenetics with the goal of developing therapeutic strategies for COL6-CMD, a rare neuromuscular disorder with which she diagnosed myself 10 years ago.

Prof. Dr. Ralph Knöll

BIH Lecture Part 2: "Basic science, novel modalities and innovative therapies for heart failure."

Cardiovascular diseases are the major cause of morbidity and mortality worldwide. Despite major recent breakthroughs regarding the underlying genetics and molecular mechanisms, our abilities to therapeutically interfere remain limited.

Here we will provide a brief overview regarding the genetics of heart failure, the downstream effects for physiology and myocardial performance as well as novel modalities, including those directly interfering with RNA and gene expression. We will also discuss novel targets for future drug development, particularly regarding the sarcomere, cardiomyocyte, and other cell types. The power of and potential use of therapeutic genome editing approaches will be discussed in the context of integrative aspects such as the cardio-renal axis and gender effects.

About the Speaker

Professor Ralph Knöll was recruited to AstraZeneca in 2014 from Imperial College where he was Professor and Chair of Myocardial Genetics from 2009 to 2014. He was formerly Professor and Head of the Working Group of Cardiovascular Molecular Genetics at the Georg August University, Göttingen, Germany from 2004 to 2009. He received his professional training as a Postgraduate Researcher and then Group Leader at the Institute of Molecular Medicine, UC San Diego, from 1999 to 2004 and clinical training at the University Hospital Benjamin Franklin, Free University Berlin (Charité) from 1996 to 1999 and at the Kerckhoff Klinik in Bad Nauheim, Germany (Arzt im Praktikum, AIP) from 1994-1996. He received his doctoral degree at the Max-Planck-Institute of Physiological and Clinical Research, Department of Experimental Cardiology, and was educated at Johann Wolfgang Goethe University Medical School, Frankfurt and Justus Liebig University Medical School, Giessen.

He received several prestigious awards, including the Berlin Institutes of Health Award 2021, the Fritz Acker Award of the German Cardiac Society (2007), the Theodor Frerichs Award of the German Society for Internal Medicine (2003) and an Astra Zeneca Award in Basic Science (2002).

Registration

The lecture will be held online.
The registration will be open until maximal participant capacity is reached.

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When
November 25, 2022
12:00 - 1:00 pm

How
online via Zoom.
The login data will be provided shortly before the event.

Registration
Registration expired.

Contact

Caroline Wiesmeier

Veranstaltungsmanagerin

Kontaktinformationen
Telefon:+49 (0) 175 51 53 653
E-Mail:caroline.wiesmeier@bih-charite.de