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  • Defining and manipulating the pharmacokinetics of extracellular vesicles
  • Development of GMP-compatible manufacturing and characterization protocols for clinical grade extracellular vesicles
  • Enhancing targeting to injured cardiovascular tissues and cardioprotective properties of extracellular vesicles

Publications  

  • Timo Z Nazari-Shafti, Christof Stamm Volkmar Falk, Maximilian Y Emmert; Exosomes for Cardioprotection: Are We Ready for Clinical Translation?; Eur Heart J. 2019 Mar 21;40(12):953-956. doi: 10.1093/eurheartj/ehz106
  • Timo Z Nazari-Shafti , Christof Stamm Volkmar Falk, Maximilian Y Emmert; The link between exosomes phenotype and mode of action in the context of cardioprotection; Eur Heart J. 2019 Oct 21;40(40):3361. doi: 10.1093/eurheartj/ehz693
  • Yepuri G, Sukhovershin R, Nazari-Shafti TZ, Petrascheck M, Ghebre YT, Cooke JP; Proton Pump Inhibitors Accelerate Endothelial Senescence; Circ Res. 2016 Jun 10;118(12):e36-42. doi: 10.1161/CIRCRESAHA.116.308807.  Epub 2016 May 10
  • Timo Z Nazari-Shafti , Vasileios Exarchos, Héctor Rodriguez Cetina Biefer, Nikola Cesarovic, Heike Meyborg, Volkmar Falk, Maximilian Y Emmert;   MicroRNA Mediated Cardioprotection - Is There a Path to Clinical Translation?; Front Bioeng Biotechnol. 2020 Mar 20;8:149. doi: 10.3389/fbioe.2020.00149.  eCollection 2020
  • Timo Z Nazari-Shafti, Zhiyi Xu, Andreas Matthäus Bader, Georg Henke, Kristin Klose, Volkmar Falk, Christof Stamm;   Mesenchymal Stromal Cells Cultured in Serum from Heart Failure Patients Are More Resistant to Simulated Chronic and Acute Stress; Stem Cells Int. 2018 Apr 1;2018:5832460. doi: 10.1155/2018/5832460.  eCollection 2018