What are human induced pluripotent stem cells (hiPSC)?
Human induced pluripotent stem cells (hiPSC) are a powerful tool in research as they are stem cells that, as similarly to embryonic stem cells, can differentiate to any somatic cell type. For more on differentiation protocols see: Differentiation & Organoids
hiPSC that can be generated directly from a somatic cell by reprogramming. The types of cells the core can use for such process include, for example, skin fibroblasts or peripheral blood mononuclear cells (PBMC). For more details on reprogramming and types of cells the core can reprogram see: Reprogramming.
What are organoids?
Organoids are groups of cells that have organised themselves into cellular structures similar to those found in different tissues and organs. Organoids can be derived from somatic as well as pluripotent stem cells. By definition organoids are comprised of several organ specific cell types that self-organize in organ typic structures and exhibit organ specific functionality. The development of methods to differentiate hiPSCs to 3D organoids permits the formation of complex patient-specific tissues, facilitating development of novel models to study human development, homeostasis and disease in a highly physiologically-relevant context.
For more on organoid protocols see: Differentiation & Organoids.
How can CUSCO support your work?
CUSCO is involved in numerous collaborations with researchers across Berlin and our involvement with each project is specifically tailored to the need of the scientist. In our laboratory space in Cranach Haus at Charité Campus Vichrow, we provide laboratory space for the users to perform cell culture and learn the hPSC techniques.
And finally, CUSCO offers expertise in experimental design, project planning and training.
How can you get started with hiPSC?
If you are interested in working with hiPSCs and/or already have an idea for a project, you can get in touch with us and request a Project Consultation.