AG Nazari-Shafti: Extracellular Vesicles as a Next Generation Cardioprotective Agent

Our junior group is part of the Translational Cardiovascular Regenerative Technologies research group (Emmert Lab) and aims to establish an interdisciplinary platform for extracellular vesicle based next generation advanced therapies for cardioprotection and myocardial regeneration. Extracellular vesicles are a promising component of the secretome of regenerative and cardioprotective cells. Our group will focus on developing sustainable therapeutic concepts based on extracellular vesicles that utilizes their cardioprotective potential to treat cardiovascular disease. Specifically, our main focus areas are:

  • Defining and manipulating the pharmacokinetics of extracellular vesicles
  • Development of GMP-compatible manufacturing and characterization protocols for clinical grade extracellular vesicles
  • Enhancing targeting to injured cardiovascular tissues and cardioprotective properties of extracellular vesicles

Publications  

  • Timo Z Nazari-Shafti, Christof Stamm Volkmar Falk, Maximilian Y Emmert; Exosomes for Cardioprotection: Are We Ready for Clinical Translation?; Eur Heart J. 2019 Mar 21;40(12):953-956. doi: 10.1093/eurheartj/ehz106
  • Timo Z Nazari-Shafti , Christof Stamm Volkmar Falk, Maximilian Y Emmert; The link between exosomes phenotype and mode of action in the context of cardioprotection; Eur Heart J. 2019 Oct 21;40(40):3361. doi: 10.1093/eurheartj/ehz693
  • Yepuri G, Sukhovershin R, Nazari-Shafti TZ, Petrascheck M, Ghebre YT, Cooke JP; Proton Pump Inhibitors Accelerate Endothelial Senescence; Circ Res. 2016 Jun 10;118(12):e36-42. doi: 10.1161/CIRCRESAHA.116.308807.  Epub 2016 May 10
  • Timo Z Nazari-Shafti , Vasileios Exarchos, Héctor Rodriguez Cetina Biefer, Nikola Cesarovic, Heike Meyborg, Volkmar Falk, Maximilian Y Emmert;   MicroRNA Mediated Cardioprotection - Is There a Path to Clinical Translation?; Front Bioeng Biotechnol. 2020 Mar 20;8:149. doi: 10.3389/fbioe.2020.00149.  eCollection 2020
  • Timo Z Nazari-Shafti, Zhiyi Xu, Andreas Matthäus Bader, Georg Henke, Kristin Klose, Volkmar Falk, Christof Stamm;   Mesenchymal Stromal Cells Cultured in Serum from Heart Failure Patients Are More Resistant to Simulated Chronic and Acute Stress; Stem Cells Int. 2018 Apr 1;2018:5832460. doi: 10.1155/2018/5832460.  eCollection 2018

Team

V. Exarchos, Doctoral Student
Magdalena Pokusa  Doctoral Student
Bhavana Vegesna Master Student

Collaborations

  • Institut für Energietechnik, ETH  Zurich, Switzerland
  • Houston Methodist Research Institute, Department for Cardiovascular Sciences, USA
  • School of Engineering, University of Glasgow, UK

Funding

  • BIH Clinician Scientist Program
  • DZHK