BIH Lecture Series: Frontiers in Translational Medicine - Scientific and Structural Challenges
During the winter semester 2019/20 the BIH starts off the new lecture series "Frontiers in Translational Medicine - Scientific and Structural Challenges" on key questions of translation in medicine. The series features lunchtime discussions with leading personalities from translational research. How must a translational ecosystem be set up, and what can we learn from international best practices? How can the success of translation be measured in the first place and how can the science system implement appropriate criteria in order to entice researchers? On Fridays at lunchtime, BIH invites an internationally renowned expert to give a lecture on these and other questions, followed by discussion and networking with the community.
Who and what
Prof. Matthias Lutolf
Scientific Director of the Roche Institute for Translational Bioengineering and
Professor of Bioengineering at the Swiss Federal Institute of Technology in Lausanne (EPFL)
> organized in cooperation with the German Stem Cell Network (GSCN)
Lecture Title: Engineering "Organoid Development"
Lecture Language: English
Friday, 17 December 2021
12:00 – 1:00 pm | BIH Lecture
1:10 – 2:00 pm | "Meet the Speaker" with Prof. Lutolf
Further information and registration here.
Lecture 19: "A Prognostic Atlas for Clinical Medicine"
On 26 November 2021, Prof. Harry Hemingway, (Research Director HDR UK | Director UCL Health Informatics | Charité Guest Professor), spoke about the systematic interrogation of data for the benefit of healthcare systems across the world. Although each patient leaves a digital trace in the electronic health record (EHR), in practice there has been a lack of systematic approaches to generating research insights across common and rare diseases using EHR. Healthcare systems know remarkably little about which patients have which diseases, in which combinations, and with what outcomes. In his lecture Hemingway presented opportunities and challenges in developing a prognostic atlas for clinical medicine. The BIH Lecture was moderated by Prof. Christopher Baum (BIH) and Prof. Christof von Kalle (Charité BIH Clinical Study Center).
Lecture 18: "Impact of Clinical Trial Data Sharing Policies"
On 8 October 2021, Florian Naudet, Professor of Therapeutics from Rennes 1 University in France, reported in the BIH Lecture on policies, practices, and problems related to the sharing and reuse of clinical trial data. The topic of the talk was related to the news in June 2021 when the European University Hospital Alliance, of which Charité is a member, signed the Sorbonne Declaration on Research Data Rights. Naudet showed that data sharing policies of journals are still poorly implemented, and clinical data sharing is not common. The lecture was moderated by Prof. Dr. Ulrich Dirnagl (BIH Chair, QUEST Center for Responsible Research).
Lecture 17: "From Molecules to Medical Records – Insights From Large-Scale, Multi-Omic Studies"
On 10 September 2021, we welcomed Prof. Dr. Claudia Langenberg, BIH Professor of Computational Medicine at the Berlin Institute of Health at Charité (BIH), as speaker of our Online BIH Lecture. Together with her team, she combines genomic with metabolomic and proteomic data to define the genetic architecture of thousands of ‘omic’ traits and integrate data from different platforms and studies to maximize power for the identification of genetic variants associated with life-long differences in metabolite and protein levels and enable investigation of their relevance for disease aetiology and prediction. While giving insights from large-scale, multi-omic studies, she spoke about her work, its importance to translational medicine, and the related challenges.
Lecture 16: "Current Status and Future Vision of Retinal Cell Therapy"
On 28 May 2021, the BIH Lecture Series took place for the second time in cooperation with the German Stem Cell Network (GSCN). This time the lecture came directly from Japan by the speaker and pioneer of iPS Therapy Masayo Takahashi (MD, PhD). Takahashi is president of the startup Vision Care Inc. and was involved in the world's first transplantation of retinal cells derived from induced pluripotent stem (iPS) cells in her role as project leader at the Riken Center for Developmental Biology. In her talk, Takahashi discussed the current status and fascinating development potential of retinal cell therapy and was available for a "Meet the Speaker" afterwards. The BIH Lecture was moderated by Prof. Hans Schöler (President GSCN) and Prof. Georg Duda (BIH Chair/Charité).
Lecture 15: "Gene Edited Human Muscle Stem Cells as Advanced Therapies"
On 23 April 2021, Prof. Dr. Simone Spuler was guest in the BIH lecture series "Frontiers in Translational Medicine - Scientific and Structural Challenges". Professor Spuler is Head of the University Out-Patient Clinic for Muscle Disorders and Senior Group Leader of the Myology Research Group at the Experimental and Clinical Research Center Charité (ECRC) of Charité - Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine (MDC). In her talk, she explained how muscle stem cells are returning to the focus of attention in the treatment of muscle wasting and demonstrated the unprecedented efficacy of gene correction strategies derived from CRISPR/Cas9 techniques in primary human muscle stem cells.
Lecture 14: "Why Translational Medicine Depends on Interoperability"
On 12 March 2021, Prof. Dr. Sylvia Thun held an online lecture in the framework of our BIH Lecture Series “Frontiers in Translational Medicine – Scientific and Structural Challenges”. Professor Thun is the Director of the Core Unit eHealth and Interoperability (CEI) at the Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin. In her talk, she explains why interoperability of medical data is fundamental to digital innovation and how it facilitates digital transformation in research and medicine, which in turn benefits patients.
Lecture 13: "The 100,000 Genomes Project – Transforming Healthcare"
On 29 January 2021, Prof. Sir Mark Caulfield MD FRCP FMedSci gave a great talk as part of our BIH Lecture Series “Frontiers in Translational Medicine – Scientific and Structural Challenges”. Professor Caulfield is Chief Scientist for Genomics England and Director of the NIHR Barts Biomedical Research Centre. In our Online BIH Lecture, he talked about the 100,000 Genomes Project, the exciting opportunities it offers researchers, and how it is advancing medical translation.
Lecture 12: "Keys to Successfull Technology Translation by Entrepeneurs in Academia and Biotech"
On 11 December 2020, Angelika Fretzen was a speaker at the BIH Lecture Series. She is Technology Translation Director, COO Wyss Institute for Biologically Inspired Engineering at Harvard University. The Wyss Institute for Biologically Inspired Engineering at Harvard University has developed a unique model that takes the most innovative ideas from 'blue sky' research by leading academic groups in the Boston area and translates them into risk-free technologies.
Lecture 11: "Cerebral Organoids - Modeling Human Development and Disease"
On 27 November 2020, Jürgen Knoblich gave a talk at the BIH Lecture Series. He is Senior Scientist and Scientific Director of the Institute of Molecular Biotechnology of the Austrian Academy of Sciences - IMBA. In his research group he is investigating cerebral organoids to recapitulate diseases of the human brain in vitro and to test risk factors. Cerebral organoids derived from patients suffering from a neurological developmental disorder can recapitulate the developmental defects leading to these diseases and allow us to unravel the mechanistic complexity of disorders such as epilepsy and autism.
Lecture 10: "Metabolic Aspects of Angiogenesis in Physiology and Disease"
On 30 October 2020, Michael Potente was speaker in the BIH Lecture Series. He is BIH Professor for Translational Vascular Biomedicine and spoke about the influence of metabolic processes on the formation of blood vessels in health and disease. Aberrant angiogenesis is a characteristic and trigger of cancer or inflammation, but therapeutic approaches have so far shown little success. New insights into the metabolic processes that small blood vessels use to form networks open up new possibilities for intervention.
Lecture 9: "The BIH - an Institute Dedicated to the Science of Translation"
On 2 October 2020, the new BIH CEO Professor Christopher H. Baum took office and took the opportunity to speak at our BIH Lecture Series. His lecture dealt with BIH and the question of how translational medicine and a science of translation can succeed.
Lecture 8: "Frontiers in Translational Mecine - An Industry Perspective"
On 31 July 2020, Florian Gantner was guest in our BIH Lecture Series. He is Senior Vice President Translational Medicine & Clinical Pharmacology at C.H. Boehringer Sohn AG & Co. KG and gave a lecture on the industrial view on the scientific and structural challenges of translation.
Lecture 7: "How to Create a Scientific Spin-off"
On 5 June 2020, Sonja Jost was a guest in our BIH Lecture Series. She is CEO of the start-up company DexLeChem and spoke in her lecture about the ways and possibilities to apply scientific knowledge about a start-up company. The seventh session of the Lecture Series was the second one that we offered completely as video conference.
Lecture 6: "What does it take to translate? – Lessons Learned in Regenerative Medicine"
On 27 March 2020, Prof. Georg N. Duda gave an insight into the experiences of the BIH Center for Regenerative Therapies (BCRT) with translation in regenerative medicine. He is co-speaker of the BCRT and director of the Julius-Woff-Institute for Biomechanics and Musculoskeletal Regeneration at the Charité - Universitätsmedizin Berlin. The sixth lecture of the series was also a premiere - in the time of the COVID 19 pandemic it was the first lecture organized by the BIH as a video conference with about 170 participants*.
Lecture 5: "Translating Data into Health – Clinical Translational Research in the Digital Age"
On 28 February 2020, Prof. Christof von Kalle gave an introduction to the challenges of Clinical Translational Research in the Digital Age. He is BIH-Chair for Clinical Translational Sciences and Director of the Clinical Study Center of the BIH and Charité - Universitätsmedizin Berlin. At our fifth session of the lecture series "Frontiers in Translational Medicine - Scientific and Structural Challenges" he spoke on "Translating Data into Health - Clinical Translational Research in the Digital Age".
Lecture 4: "From Infection Research to New Antiviral Drugs"
On 14 February 2020, Prof. Susanne Herold presented the perspective of Clinician Scientists on translational research. She is Professor of Lung Diseases at the University Hospital Gießen-Marburg, where she heads the Department of Infectiology. At our fourth session of the lecture series "Frontiers in Translational Medicine - Scientific and Structural Challenges" she spoke on the topic "From infection research to new antiviral drugs" and gave an insight into her current research.
Lecture 3: "Immunological Challenges of Regenerative Therapies - what, why, how?"
On 31 January 2020, the BIH again invited participants to reflect and discuss the challenges of translational research in the historic Virchow lecture hall of the Charité – Universitätsmedizin Berlin. At the third lecture of the series and the first one this year, Prof. Hans-Dieter Volk, speaker of the BIH Center for Regenerative Therapies, spoke on the topic "Immunological Challenges of Regenerative Therapies - what, why, how?"
Lecture 2: "Debunking Common Myths about Translation"
On 22 November 2019, the BIH invited to the second lecture of the series. Prof. Ulrich Dirnagl, founding director of the BIH QUEST Center, spoke on "Debunking Common Myths about Translation". He argued that, over the last twenty years, ideas of translation have become ingrained that were not true and distracted from different or even better approaches to translation medicine.
Lecture 1: "Frontiers in Translational Medicine - Scientific and Structural Challenges"
Professor Axel Radlach Pries, Chairman of the BIH Board (interim) and Dean of the Charité - Universitätsmedizin, opened the new lecture series on 8 November 2019 in the Hans Virchow lecture hall of the Charité Campus Mitte. With questions and answers on the structures and conditions of successful translational medicine, he addressed all those interested in translation and the work of BIH.