The QUEST Center plans and implements various projects and measures, among others in collaboration with the Department of Experimental Neurology Charité – Universitätsmedizin Berlin.

The unique feature: The activities of the QUEST Center have a very practical relevance - an translational approach - as we seek to test new approaches in design, analysis and reporting at the Berlin Institute of Health (BIH) building a bridge between basic research and clinical care. The procedures and projects to be implemented are identified by so-called "meta-research", i.e. research on research. During and after the implementation, we also want to examine the effectiveness. The QUEST projects focus on matters such as systematic reviews, Open Science (open data, metadata, and ontologies), Citizen Science, Science Policy, (incentives and rewards in academia, new metrics and indicators), Replication and Reproducibility, Electronic Laboratory Notebook, registration and publication of clinical studies, teaching and quality management in the preclinical research.

In collaboration with the German Centre for Higher Education Research and Science Studies, the QUEST Center also conducts research on translation. The respective reports are listed below.


EQIPD is a collaborative project between the QUEST Center and the Department of Experimental Neurology (Charité) and aims to advance the quality and efficiency of discovery of R&D data by developing a simple, flexible, efficient system that can improve the rigor and robustness of preclinical neuroscience and saftey research in academia and industry. 

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Extent, Predictors, and Management of Publication Bias in Animal ResearCh (EMBARC)

EMBARC examines to what extent, in what form and in what time previously approved animal testing applications have published their results and study methods. EMBARC will then use expert interviews on publication bias to examine the attitudes and approaches of the various stakeholders in the context of animal research.

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GEENGOV: Governance of Research using Genom Editing Technology in Humans

GEENGOV is concerned with issues of regulating research that employs modern genome editing (e.g. CRISPR-Cas9) technology on somatic cells of humans. The project focuses on three important questions: (1) How can risk-benefit-assessments of GEEN-studies on human somatic cells be conducted systematically and professionally? (2) How can we ensure valid informed consent is provided by patients and participants of studies or so called “Heilversuche” employing such technology? (3) Is there a need for additional regulation by the state or other institutions (governance) or are established regulatory mechanisms and institutions sufficient?

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GOT-IT – Guidelines on Target Validation for Innovative Therapeutics within the BMBF funded consortium project: Target validation for pharmaceutical drug compound development

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Good Justification Practice

The project Good Justification Practice investigates how research decisions in translational biomedicine can be justified prospectively in order to meet bioethical requirements. What is necessary to be able to assess in advance whether probability statements about the expected success of a research project in translational biomedicine are well-founded? Which criteria can be used to accomplish this?

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With PREMIER (Predictiveness and Robustness through Modular Improvement of Experimental Research), we aim to improve the development of structured quality assurance consisting of modular elements in which high-quality preclinical research is feasible and practicable. We want to improve robustness and value of research and a proof of concept of structured quality assurance in preclinical academic biomedicine, to provide preliminary (indirect) evidence for its efficacy, and to lay the foundations for the scientific community to further jointly modify and improve such an ‘open’ system.

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Publication of results from clinical trials (IntoValue)

One of our first projects, the IntoValue project, is concerned with the publication of clinical trials. The publication of all results from clinical trials is an important component for improving biomedical research and reducing the amount of unused research results. 

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Stakeholder Engagement in Biomedical Research

This project aims at examining conceptual, structural and normative questions of engaging stakeholders as partners in planning, conducting and evaluating diverse research projects in biomedicine. The aim is to develop practice-oriented recommendations for implementation of engagement activities in biomedical research based on fundamental conceptual work and an analysis of the status quo of stakeholder engagement in Germany. 

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Research on Translation

The project series Research on Translation aims at analysing the definition of translational research, contributing to a clearer picture of the organization of translational research, and investigating the implementation of translational research within BIH.

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A qualitative study on the basis of expert interviews

In response to what has been called the “reproducibility crisis”, institutions and granting agencies have begun to implement changes in how biomedical research activity is rewarded and funded. The aim of the present project is to gain a better understanding of how different stakeholders view these ongoing reforms.

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QUEST criteria - Attributes of robust and innovative research

The so-called QUEST criteria relate to quality, ethics, open science and translation of biomedical research at BIH. The goal is to map the robustness, reproducibility and confirmability of research projects and hence to best possible stimulate the existing potential for innovation.

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QUEST publication record (PURE)

The aim is to create a comprehensive and continuously updated publication body of publications from the joint research area Charité, MDC and BIH.

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