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Cardiovascular diseases are the main cause of death worldwide. Heart failure is a global pandemic and is increasing in prevalence, indicating the need for better treatment options. The research field focuses at finding patient-specific therapy concepts for the treatment of heart failure. With inflammation being an important predictor for a worse outcome in heart failure, we search for novel or repurposed anti-inflammatory and immunomodulatory therapies, including the evaluation of cell-based therapies. Our research is further directed at finding strategies which lead to cardiomyocyte regeneration.With valve disease being one of the causes of heart failure and the degeneration of existing heart valves protheses requiring multiple re-interventions, one arm of our research is focused at developing regenerative heart valves.

Aims

  • Stratification of heart failure patients based on phenomapping
  • Identification of patient-specific therapy options (precision medicine)
  • Immunocardiology
  • Development of novel (cell-based) therapies for the treatment of heart failure
  • Development of cardiomyocyte regeneration strategies
  • Development of regenerative heart valves

Research Groups

  • Working group

    In situ Tissue Engineering

    Michael Sittinger

    The team of Michael Sittinger has nearly 30 years of experience with pioneering work in the field of 'Tissue Engineering'. Their current work specifically adresses individual translational challenges…

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  • Working group

    Cardiomyocyte restoration and matrix support

    Christof Stamm

    The human heart has very restrictive regenerative capacity in response to injury. The extensive loss of cardiomyocytes in acute myocardial infarction or end-stage heart disease is not compensated by…

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  • Working group

    Immunocardiology

    Carsten Tschöpe

    Inflammation is recognized as an important predictor for a worse outcome in heart failure. Underlying mechanisms of cardiac inflammation involving the innate and adaptive immune system, are…

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  • Working group

    Experimental Immunocardiology

    Sophie Van Linthout

    Our research is focused at exploring the role of the innate and adaptive immunity in the pathogenesis of non-ischemic heart failure with main interest in inflammatory cardiomyopathy and heart failure…

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