We are working on clear cell Renal Cell Carcinoma (ccRCC). Kidney cell carcinomas of this cell type are by far the most frequently occurring ones. Tumor stem cells control the growth of tumors and play a crucial role in metastasis as well as in how the tumors respond to drug therapy approaches. We have observed that the tumor stem cell carcinomas respond differently among individual patients to drugs already employed and those under development. Whereas the tumor stem cells of some patients show a very good response to a treatment, those of other patients do not, or do so only weakly. Our project aims to develop novel therapy strategies that specifically target cancer stem cells in clear cell Renal Cell Carcinoma and to identify molecular markers that can predict therapeutic responses. For this purpose, we analyze the genome, the transcription (all genes transcribed, i.e. rewritten as RNA by DNA, in a cell at a given point), and the epigenetic signature of the tumor cells, which shows us which regulators influence the development of the cell and its succeeding generations. Ultimately, these results are to be used in the development of new therapies. We are also using the results to derive new, non-invasive markers from the molecular signature of tumor stem cells circulating in the blood of patients with metastasizing kidney carcinomas.