Psychiatric disorders represent an immense burden for the individuals affected and for their environment. In many fields of medicine, there has been significant diagnostic and therapeutic progress over the last few years because specific physiological and biochemical changes have been discovered. However, there have been hardly any improvements for patients suffering from psychiatric diseases. The overarching goal of our project is to gain a better understanding of how characteristic symptoms of schizophrenia (delusions and hallucinations) are generated, and for this purpose, we are trying to understand the basic disease mechanisms at the level of neuronal circuits. By focusing on this objective, our work can make a sustainable contribution to the pathophysiology of psychotic disorders. Our results could help in developing innovative methods for diagnosis and treatment.