The QUEST Center plans and implements various projects and measures, between others in collaboration with the Department of Experimental Neurology Charité - Universitätsmedizin Berlin.
The unique feature: The activities of the QUEST Center have a very practical relevance -the translational approach- as we seek to test new approaches in design, analysis and reporting at the Berlin Institute of Health (BIH) building a bridge between basic research and clinical care.
Electronic Lab Notebook
Electronic lab notebooks (eLNs) facilitate collaborations within and between team groups ("team science"). We offer an eLN for interested BIH researchers from the Charité and perspectively the MDC.
The PREMIER project, funded for three years by the Volkswagenstiftung, aims to develop a structured quality assurance system for preclinical academic biomedicine.
DECIDE – Decision-Enabling Confirmation of Innovative Discoveries and exploratory Evidence – is the accompanying project within the BMBF funded consortium Richtlinie zur Förderung von konfirmatorischen präklinischen Studien – Qualität in der Gesundheitsforschung (Guidelines for Promotion of Confirmatory Preclinical Studies – Quality in Health Research)
EQIPD (European Quality In Preclinical Data) is a project of a European consortium project consisting of members from European Federation of Pharmaceutical Industries (EFPIA) and from academia which is funded for three years by IMI (Innovative Medicines Initiative) which belongs to the EU-program Horizon 2020.
GOT-IT – Guidelines on Target Validation for Innovative Therapeutics within the BMBF funded consortium project: Target validation for pharmaceutical drug compound development
The GOT-IT Project will support academia-industry interactions by aligning quality criteria in pre-clinical research in form of Target Validation Guidelines.
Guidelines for Safeguarding Good Research Practice (Code Project)
In August 2019, the German Research Foundation (DFG) published the "Guidelines for Safeguarding Good Research Practice (Code)". The Code "is intended to create a deeply rooted culture of research integrity at higher education institutions, focusing less on breaches of good scientific practice and more on the professional ethics of researchers”. When the Code comes into force on 1 August 2019, all universities and non-university research institutions must implement the 19 guidelines in a legally binding manner in order to receive funding from the DFG.
LabCIRS – a Laboratory Critical Incident and Error Reporting System for preclinical research
The LabCIRS (Laboratory Critical Incident and Error Reporting System) is an anonymous error reporting system that was developed by the Department of Experimental Neurology at the Charité together with the QUEST Center at the BIH and is made available to the Charité - as well as to the entire scientific community.
Promoting quality assurance in preclinical research (Q-EBRA)
Q-EBRA is a six month project synthesizing existing standards for preclinical research with the latest meta-research findings to improve research quality. Based on this synthesis, open educational materials are provided for use in grant review procedures.
The QUEST Toolbox
The QUEST Toolbox contains helpful tools, programs and online platforms that aim at facilitating the reproducibility of a research project on all stages. The tools are sorted along the stages of the life cycle of a research project. The QUEST toolbox is aimed specifically at biomedical researchers. While some tools are specific to that community, others are of usage also in other research communities. We tried to go for non-commercial tools wherever possible.
SPOKES - Grassroots Traction for Value-Based Research Culture
SPOKES aims to promote active grassroots involvement of researchers in the improvement of biomedical research of their own research environment. In 2020, the SPOKES Review Board will select five new SPOKES Wellcome Trust Funded Translational Partnership Fellows from mid-career researchers employed at the Charité (senior postdocs and junior group leaders) who will work together to develop, implement and track new initiatives for improving science within their own research groups. Furthermore, SPOKES will be setting-up a Think Tank for doctoral students and junior postdocs. In addition to mentoring and education opportunities, Think Tank members will receive funding for the development of a project aiming to overcome hurdles to translation.