GEENGOV: Governance of Research using Genom Editing Technology in Humans (closed)
GEENGOV is concerned with issues of regulating research that employs modern genome editing (e.g. CRISPR-Cas9) technology on somatic cells of humans. The project focuses on three important questions: (1) How can risk-benefit-assessments of GEEN-studies on human somatic cells be conducted systematically and professionally? (2) How can we ensure valid informed consent is provided by patients and participants of studies or so called “Heilversuche” employing such technology? (3) Is there a need for additional regulation by the state or other institutions (governance) or are established regulatory mechanisms and institutions sufficient?
Guidelines for Safeguarding Good Research Practice (KODEX Project) (closed)
In August 2019, the German Research Foundation (DFG) published the "Guidelines for Safeguarding Good Research Practice (KODEX)". The KODEX "is intended to create a deeply rooted culture of research integrity at higher education institutions, focusing less on breaches of good scientific practice and more on the professional ethics of researchers”. When the KODEX comes into force on 1 August 2019, all universities and non-university research institutions must implement the 19 guidelines in a legally binding manner in order to receive funding from the DFG.
QUEST Clinical trial reporting manual (closed)
Most universities in the EU are currently failing to upload clinical trial results onto registries, leading to research waste and incomplete outcome reporting. Universities are often unclear about how to (a) upload the results of old trials, and (b) set up systems that ensure timely results posting going forward. This creates a barrier to improved performance. The aim of the project is to draw together the experiences and lessons learnt by front-runner universities that have successfully tackled the problem, and develop a hands-on manual for other universities that wish to do the same.
QUEST criteria - Attributes of robust and innovative research (MERIT) (closed)
The so-called QUEST criteria relate to quality, ethics, open science and translation of biomedical research at BIH. The goal is to map the robustness, reproducibility and confirmability of research projects and hence to best possible stimulate the existing potential for innovation.
Promoting quality assurance in preclinical research (Q-EBRA) (closed)
Q-EBRA is a six month project synthesizing existing standards for preclinical research with the latest meta-research findings to improve research quality. Based on this synthesis, open educational materials are provided for use in grant review procedures.
A qualitative study on the basis of expert interviews (closed)
In response to what has been called the “reproducibility crisis”, institutions and granting agencies have begun to implement changes in how biomedical research activity is rewarded and funded. The aim of the present project is to gain a better understanding of how different stakeholders view these ongoing reforms.
Research on Translation (closed)
The project series Research on Translation aims at analysing the definition of translational research, contributing to a clearer picture of the organization of translational research, and investigating the implementation of translational research within BIH.