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We aim to understand the genetic principles of gene regulation and how they are connected to cell differentiation and disease. For this we combine genome engineering in mouse embryonic stem cells with cell differentiation systems and cutting-edge genomic analyses.

Our research focuses on the regulation of key genes in vertebrate heart development as well as the identifying causative genetic variants underlying early onset osteoporosis. For this we map the important gene regulatory elements in osteoclasts and osteoblasts, two cell types controlling in bone development and homeostasis.

Research focus

  • linking 3D chromatin structure to gene regulation and disease
  • development of complex and/or high-throughput genome engineering to create genetic models of disease
  • gene regulatory control of vertebrate heart development and cardiac cell differentiation
  • Defining the active regulatory genome in osteoblasts and osteoclasts
  • Genetic variant interpretation of heredetary osteoporosis