Na Lab - Therapy-Induced Remodeling in Immuno-Oncology

The Na lab investigates defects and dysfunctions of the immune system in cancer patients. Focus are disease- and therapy-induced effects on immune cells, tumor cells and their interaction as well as the reconstitution of the immune system after treatment.

We pursue a “next generation staging” in order to better understand the dynamic changes during conventional chemotherapy, targeted therapies, and immunotherapies. For this purpose, we longitudinally and comprehensively monitor dynamic modifications of the immune system, the tumor and the tumor microenvironment enforced by the chosen treatment.

Aims are the gain of critical individualized information for tailored treatment approaches (combination strategies, patient selection, novel targets) and the development of novel strategies to restore the immune competence after treatment.

Research focus

  • Adoptive T cell therapy
  • Bone marrow - target of alloreactive T cells and immunological niche
  • Immune reconstitution after allogeneic hematopoietic stem cell transplantation
  • Therapy-induced remodelling in lymphoma patients

For more detailed information please visit the MDC-website.

Selected publications

Na IK, Buckland M, Agostini C, Edgar JDM, Friman V, Michallet M, Sánchez-Ramón S, Scheibenbogen C, Quinti I. Current clinical practice and challenges in the management of secondary immunodeficiency in hematological malignancies. Eur J Haematol. 2019 Feb 22. doi: 10.1111/ejh.13223

 

Becker SC, Szyska M, Mensen A, Hellwig K, Otto R, Olfe L, Volk HD, Dörner T, Dörken B, Scheibenbogen C, Schröder J, Hocke AC, Na IK. A comparative analysis of human bone marrow-resident and peripheral memory B cells. J Allergy Clin Immunol. 2018 May;141(5):1911-1913.e7. doi: 10.1016/j.jaci.2017.12.983.

Hammer Q, Rückert T, Borst EM, Dunst J, Haubner A, Durek P, Heinrich F, Gasparoni G, Babic M, Tomic A, Pietra G, Nienen M, Blau IW, Hofmann J, Na IK, Prinz I, Koenecke C, Hemmati P, Babel N, Arnold R, Walter J, Thurley K, Mashreghi MF, Messerle M, Romagnani C. Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells. Nat Immunol. 2018 May;19(5):453-463. doi: 10.1038/s41590-018-0082-6.

Szyska M, Herda S, Althoff S, Heimann A, Russ J, D'Abundo D, Dang TM, Durieux I, Dörken B, Blankenstein T, Na IK.A Transgenic Dual-Luciferase Reporter Mouse for Longitudinal and Functional Monitoring of T Cells In Vivo. Cancer Immunol Res. 2018 Jan;6(1):110-120. doi: 10.1158/2326-6066.

Hemmati PG, Vuong LG, Terwey TH, Jehn CF, le Coutre P, Penack O, Na IK, Dörken B, Arnold R. Predictive significance of the European LeukemiaNet classification of genetic aberrations in patients with acute myeloid leukaemia undergoing allogeneic stem cell transplantation. Eur J Haematol. 2017 Feb;98(2):160-168. doi: 10.1111/ejh.12815.