People are at the heart of BIH’s work, and we aim to attract, develop and retain the brightest minds of trans lational research and management. We already have dedicated researchers and staff, but to meet our Strategy 2026 goals, we plan to recruit more by applying proven bestpractice approaches and embracing gender equality and internationalization.We aim to have filled dozens of key posts for the translational research commons by 2026, from BIH chairs to BIH professorships and junior group leaders.
Rapid advances in molecular biology technologies are leading to a data explosion in biomedical research and clinical diagnostics. The goal of our department is to develop new and targeted ways to analyze and evaluate these data sets in order to implement innovations that benefit patients. For…
The research group Model Systems for Regenerative Therapies leverages interdisciplinary approaches to interdisciplinary and translational research. Our goal is to improve our mechanistic pathophysiological understanding regarding musculoskeletal fibrosis to a level where we can offer effective…
Genetic sequencing, an essential method in life science, is mainly driven by fluorescence imaging. In the advent of spatial imaging and in situ sequencing directly on cells and human tissues, we aim to apply latest deep learning and microscopic automation for translational medicine and molecular…
We investigate clinical pathophysiological metabolic changes of muscle and fat tissue in chronic diseases. In clinical work, cardiovascular knowledge is combined with acute therapy and stroke rehabilitation. Our research is focused on metabolic pathophysiology, which leads to weight loss and loss of…
Both mechanical and biological processes work together to determine the outcome of musculoskeletal regeneration. Whilst many of the biological factors have been identified and some even brought into clinical practice (BMP's, PDGF, IGF, etc.), the impact of the mechanical environment and the role of…
Roland Eils' department at BIH consists of four working groups: Artificial Intelligence (Roland Eils), Computational Oncology (Naveed Ishaque), Health Data (Harald Wagener, Sven Twardziok, Dirk Meyer zum Büschenfelde) and Medical Omics (Sören Lukassen). The department is part of the BIH Center of…
Tissues in the musculoskeletal system are exquisitely designed with superb mechanical properties. The tissues are also able to adapt to withstand changing mechanical conditions. The Computational Mechanobiology Group is focused on understanding these two exciting features. Using computer modeling…
The Musculoskeletal Cell Biology research group adopts an integrative and interdisciplinary approach to investigate the regeneration of musculoskeletal tissues. The group focuses on uncovering the cellular and molecular mechanisms underlying impaired healing processes, such as those observed in bone…
The Integrative Vascular Biology Laboratory aims to unravel the fundamental principles and molecular/genetic regulation of functional vascular network formation in development and disease.
The Gütig lab uses analytical and numerical modeling techniques to identify the computational principles underlying spike based information processing and learning in central nervous systems and to understand how these principles are implemented by biological processes. Specifically, the lab focuses…
The Haas group develops and applies novel multimodal single-cell and spatially-resolved technologies to study the complex etiology of hematological cancers and their interaction with the immune system.
We are fascinated by the molecular processes of life and study how genetic and particularly environmental factors shape health and disease. Using mass spectrometry, we capture molecular and biochemical signatures from microbial cells to clinical samples to tackle key questions in infection biology:…
Our research aims to understand the principles of gene regulation, how they control cell differentiation, and how these are disrupted in disease. We investigate these questions through systematic genome engineering. We create specific mutations in the genome and then study how they alter expression…
Our research focuses on patient involvement, rare diseases, cancer and digitalization.
Through the development and implementation of science-based tools and policies, the group contributes to the alignment of internal administration and governance processes of incentives and research assessments with responsible research and innovation (RRI) as well as open sciences practices. The…
Since 2017, Martin Kircher heads the "Computational Genome Biology" working group at BIH. With the appointment as professor for regulatory genomics at the University of Lübeck and the University Hospital Schleswig-Holstein in 2022, Prof. Kircher continued his research as a BIH Fellow at the two…
Our research focuses on molecular changes in the development of various tumors. We now want to use bioinformatic and experimental methods to better understand the early development of cancer in order to be able to intervene and prevent it in the long term.
The theme of reproducibility in science will be explored in a virtual fireside chat with Dr Stuart Ritchie, Lecturer at the Institute of Psychiatry, Psychology and Neuroscience at King’s College London and author of the best-selling book Science Fictions.
Prof. Lehmann's Molecular Epidemiology research group at BIH and Charité investigates the pathomechanisms and risk factors of lung diseases with the aim of developing new diagnostic and therapeutic strategies, as well as identifying high-risk patients at an early stage and developing targeted…
Hematopoiesis describes the process of blood formation and is sustained by the activity of hematopoietic stem and progenitor cells throughout our lifetime. While our understanding of stem cell biology continues to grow, it still remains challenging to study the in vivo activity of individual stem…
The Medical Omics lab aims to improve healthcare and basic research by providing artificial intelligence-driven tools for the analysis of large biomedical datasets. For comprehensive insights in disease entities, we aim to include multiple layers of data, such as single-cell RNA sequencing,…
The "Responsible Algorithms" research group operates at the intersection of Trustworthy AI and meta-research. It focuses on the analysis, development, and implementation of strategies to enhance the robustness and transparency of AI applications. In particular, the group explores methods for…
The Computational Neurology group develops theory- and data-based methods with the goal of achieving a more comprehensive understanding of neurological system function. In addition to the general goal of a more quantitative neurology, this approach should contribute to a more objective, real-time…
The research team headed by Prof. Dr Il-Kang Na is working on optimizing the functionality of immune cells for cancer therapy. The focus is to decipher the individualized immune-onco-dynamics and exploring the susceptibility of tumor cells to immune cells. The main goal is to perform better…
Defects in musculoskeletal tissues, e.g. in consequence of a trauma, do not always heal spontaneously but require surgical intervention. Biomaterials implanted into the defect region have to potential to support the healing process. We investigate the interaction between cells, their surrounding…
The Poikela group aims at understanding patients’ views on privacy and strengthening trust through innovative privacy-enhancing solutions in order to support the patients’ willingness to disclose data for medical research, and to enhance adoption of digital health solutions. The work takes the form…
Not only the DNA sequence – our genome – but also the 3D structure of our genome – the 'epi-genome' – is essential in determining the type and function of a cell. That's why the analysis of the epigenome facilitates deep insights into the developmental history of a cell and its current gene…
The Potente laboratory focuses on the vasculature—the largest organ in the human body. We study how vascular networks develop and remodel and how their function becomes abnormal in disease states.
Further advancing digital medicine requires innovative solutions for integrating healthcare and medical research data. From the perspective of medical informatics, there are important open questions. How can the required collection, integration and analysis of large and heterogeneous data sets be…
Brain simulation helps us understanding how our brain works – and developing personalized therapies for its diseases
Our lab is made up of bioinformaticians, computer scientists, ontologists, curators, and software engineers. Our mission is to develop software resources and algorithms to improve human health. Our research focuses on the development of ontologies and software for translational genomics.
The goal of our "Personalized Medicine in Infectious Diseases" research group is to develop innovative preventive and therapeutic strategies against infectious diseases and their consequences. Infectious diseases are not only among the leading causes of death worldwide, but they are also directly…
We sequence cells to understand how genetic mutations form and change cell states in health and disease.
The Sawitzki lab investigates the molecular mechanisms of immune cell activation and tolerance induction, in order to better understand why components of the immune response themselves become a trigger of destructive inflammatory reactions, like e.g. in the context of autoimmune diseases, rejection…
Chronic low back pain is a significant public health problem in industrialized society. The intact spine carries the upper body and external loads, allows motion in a physiological range and protects the spinal cord. These different demands necessitate a high degree of complexity with various…
Bone is an interesting tissue from the researchers view as it is able to regenerate after injury. However, even today and with an adequate treatment 5-20% of all fractured patients experience a delayed or non-union.
We are dedicated to harnessing the power of T cells to combat viral infections, autoimmune diseases, and cancer. Our research centers on understanding how T cells develop effective immune memory against virus-infected and tumor cells, and how we can strategically modify these responses for…
Hypertension affects more than one billion people worldwide. As the leading risk factor for global disease burden, it contributes to more than nine million deaths annually. The mission of the Scholl group is the discovery and characterization of novel mechanisms underlying human disease. We focus on…
The main research area of the Bioinformatics and Translational Genetics group is the elucidation of single gene disorders (rare diseases caused by DNA mutations in a single gene). We are developing user-friendly software that can be used by non-IT specialists. This allows the physicians – who know…
The team of Michael Sittinger has nearly 30 years of experience with pioneering work in the field of 'Tissue Engineering'. Their current work specifically adresses individual translational challenges and missing links for feasibility of regenerative therapies in different clinical research…
The area of „Meta-Research and Translational Bioethics“ addresses epistemological and ethical issues in biomedical research. In empirical studies, we investigate how measures to promote trustworthiness, utility and ethics in biomedical research (e.g. publication of results, patient participation or…
The Thun Research Group (Digital Medicine and Interoperability) brings together experts in medicine, computer science, health data science, and artificial intelligence. Our goal is to develop digital infrastructures and standards for a connected, interoperable healthcare system. We conduct research…
The group „Systemic Perspectives in Translational Biomedicine” investigates research processes in (preclinical) biomedical research. The path from an initial discovery to the patient is long and challenging. One important building block of successful translation is the generation of robust evidence.…
The objective of our research group is to acquire the basic knowledge necessary to develop new therapies against diseases affecting the liver. For that, we use stem cells to model embryonic development in vitro and to produce liver cells with an interest for cell therapy.
Despite the high incidence of muscle injuries, degenerative joint or spinal diseases, and other musculoskeletal disorders such as tendon or bone pathologies, the fundamental issue - biological regeneration - has not yet been solved in clinical practice. Since 2006, we have been working on…
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