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Preregister your preclinical studies challenge – Increase the credibility of your results and get early credit for your ideas!

'Transparency and independent replication are core values of science. However, scientists must publish, which is more likely with positive results, even at the expense of transparent, reproducible research. Thereby the reported positive results often do not reflect the original hypothesis. What is good for science and what is good for scientists are not always the same.

Preregistration adds additional credibility to results by documenting in advance what will be tested. Preregistration separates hypothesis testing (confirmatory) from hypothesis generating (exploratory) research. Both are important. However, the same data cannot be used to generate and test a hypothesis, which often happens unintentionally. With preregistration, confirmatory analyses are planned in advance in order to retain the validity of their statistical inferences, and exploratory analyses are reported as post hoc investigations that might inspire confirmatory tests in future studies.' (modified after: https://cos.io/prereg/).

The Center for Open Science has launched a Preregistration Challenge. The QUEST Center supports their Preregistration Challenge with its own challenge, focused on preclinical studies!

In clinical science, preregistration of controlled clinical trials is a prerequisite for publication in most relevant journals (Consort statement). However, in preclinical research, which is currently suffering from a reproducibility crisis, preregistration is a novel concept.

QUEST is offering this award of 1,000 € to first/last/corresponding BIH or Charité authors (and employees) of papers published from 2017 onwards. Following international definitions of preclinical research we consider studies using animals, cells or other disease models.
Prizes can be spent until the end of 2023. Awards are given on an ongoing basis. Awardees will be featured on the QUEST web pages.

Various forms of preregistration are eligible for an award, e.g. in journals such as Biorvix, portals such as Figshare or Aspredicted, in the Animal Study Registry of the German Federal Institute for Risk Assessment (BfR), or in other suitable formats accessible on the Internet and bearing a tamper-proof date stamp.

Registered reports (e.g. at eLIFE or Cortex) and embargoed preregistrations are also eligible.


Only one QUEST Prize can be awarded per publication. Authors can apply (with different publications) only once per year per prize (i.e. maximum 5 prizes per year per author).

Publications of authors (independent of the author´s position) which are also QUEST employees cannot be considered.

To claim your award, send an email with a short statement and the publication to quest@bih-charite.de.


Here you will find the list of already funded publications on Preregistration Award. (no applications received yet)

Preregistrations in many forms are eligible: for example in journals like Biorxiv, or in outlets like Figshare or Aspredicted, in the Animal Study Registry of the Bundesinstitut für Risikobewertung (BfR) or in other appropriate formats that are accessible on the internet and provide a tamper-proof time stamp. Registered reports (e.g. at eLIFE or Cortex) and embargoed preregistrations are also eligible.