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'Transparency and independent replication are core values of science. However, scientists must publish, which is more likely with positive results, even at the expense of transparent, reproducible research. Thereby the reported positive results often do not reflect the original hypothesis. What is good for science and what is good for scientists are not always the same.

Preregistration adds additional credibility to results by documenting in advance what will be tested. Preregistration separates hypothesis testing (confirmatory) from hypothesis generating (exploratory) research. Both are important. However, the same data cannot be used to generate and test a hypothesis, which often happens unintentionally. With preregistration, confirmatory analyses are planned in advance in order to retain the validity of their statistical inferences, and exploratory analyses are reported as post hoc investigations that might inspire confirmatory tests in future studies.' (modified after: https://cos.io/prereg/).

The Center for Open Science has launched a Preregistration Challenge. The QUEST Center supports their Preregistration Challenge with its own challenge, focused on preclinical studies!

In clinical science, preregistration of controlled clinical trials is a prerequisite for publication in most relevant journals (Consort statement). However, in preclinical research, which is currently suffering from a reproducibility crisis, preregistration is a novel concept.

Berechtigte Präregistrierungen

Information for your application

  • The QUEST center is offering this award of 1,000 € to first/last/corresponding BIH or Charité authors (and employees). Following international definitions of preclinical research we consider studies using animals, cells or other disease models.
  • Papers published from 2017 onwards are accepted.
  • Prizes can be spent until the end of 2024. Awards are given on an ongoing basis.
  • Only one QUEST Prize can be awarded per publication.
  • Authors can apply (with different publications) only once per year per prize (i.e. maximum 5 prizes per year per author).
  • Publications of authors (independent of the author´s position) which are also QUEST employees cannot be considered.
  • Awardees will be featured on the QUEST web pages.

To apply for the award, please fill out the registration form that you can find here

Awarded publications

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QUEST Center

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