The QUEST Center plans and implements various projects and measures, between others in collaboration with the Department of Experimental Neurology Charité - Universitätsmedizin Berlin.
The unique feature: The activities of the QUEST Center have a very practical relevance -the translational approach- as we seek to test new approaches in design, analysis and reporting at the Berlin Institute of Health (BIH) building a bridge between basic research and clinical care.
Berlin University Alliance Open Science Dashboards
Aims to include FAIR criteria in the Charité Metrics Dashboard and co-develop prototype open science dashboards for other research fields.
Concept development for collaborative research data management services
This project aims to assess the needs of Charité researchers with respect to research data management, to develop concepts for related services, and to build communities around similar data management practices. The project is funded by the Berlin University Alliance (BUA) and takes place in collaboration with partners of all Alliance institutions.
DECIDE – Decision-Enabling Confirmation of Innovative Discoveries and exploratory Evidence – is the accompanying project within the BMBF funded consortium Richtlinie zur Förderung von konfirmatorischen präklinischen Studien – Qualität in der Gesundheitsforschung (Guidelines for Promotion of Confirmatory Preclinical Studies – Quality in Health Research)
Einstein Center 3R (EC3R)
EC3R focuses on the development of 3D-tissue-culture models to reduce and replace animal experiments. QUEST will extend the 3R focus by additional 3Rs (robustness, registration, reporting).
Electronic Lab Notebook
Electronic lab notebooks (eLNs) facilitate collaborations within and between team groups ("team science"). We offer an eLN for interested BIH researchers from the Charité and perspectively the MDC.
EQIPD (European Quality In Preclinical Data) is a project of a European consortium project consisting of members from European Federation of Pharmaceutical Industries (EFPIA) and from academia which is funded for three years by IMI (Innovative Medicines Initiative) which belongs to the EU-program Horizon 2020.
German Reproducibility Network (GRN)
The QUEST Center is one of the founding members of the German Reproducibility Network (GRN), which is a cross-disciplinary consortium that aims to increase trustworthiness and transparency of scientific research on a national level.
GOT-IT – Guidelines on Target Validation for Innovative Therapeutics within the BMBF funded consortium project: Target validation for pharmaceutical drug compound development
The GOT-IT Project will support academia-industry interactions by aligning quality criteria in pre-clinical research in form of Target Validation Guidelines.
LabCIRS – a Laboratory Critical Incident and Error Reporting System for preclinical research
The LabCIRS (Laboratory Critical Incident and Error Reporting System) is an anonymous error reporting system that was developed by the Department of Experimental Neurology at the Charité together with the QUEST Center at the BIH and is made available to the Charité - as well as to the entire scientific community.
The PREMIER project, funded for three years by the Volkswagenstiftung, aims to develop a structured quality assurance system for preclinical academic biomedicine.
The QUEST Toolbox
The QUEST Toolbox contains helpful tools, programs and online platforms that aim at facilitating the reproducibility of a research project on all stages. The tools are sorted along the stages of the life cycle of a research project. The QUEST toolbox is aimed specifically at biomedical researchers. While some tools are specific to that community, others are of usage also in other research communities. We tried to go for non-commercial tools wherever possible.
RE-PLACE investigates the implementation of the electronic laboratory notebook labfolder as an instrument of quality assurance in biomedical research.
Clinical trial reporting
As a result from our Clinical trial reporting Workshop aiming to improve clinical trial registration and summary results posting at German University Medical Centres we have collected background readings and tips, tricks and tools to report clinical trials.
SPOKES - Grassroots Traction for Value-Based Research Culture
SPOKES aims to promote active grassroots involvement of researchers in the improvement of biomedical research of their own research environment. In 2020, the SPOKES Review Board will select five new SPOKES Wellcome Trust Funded Translational Partnership Fellows from mid-career researchers employed at the Charité (senior postdocs and junior group leaders) who will work together to develop, implement and track new initiatives for improving science within their own research groups. Furthermore, SPOKES will be setting-up a Think Tank for doctoral students and junior postdocs. In addition to mentoring and education opportunities, Think Tank members will receive funding for the development of a project aiming to overcome hurdles to translation.
VALUE AND OPEN SCIENCE PROGRAM - NeuroCure
NeuroCure has established a program called VOS (Value and Open Science) to specifically increase the reliability, robustness, reproducibility, transparency and predictive power of its research.
Workshops for European Brain Research Area (EBRA) grant recipients
For researchers funded by EBRA, QUEST organises a series of workshops on quality and transparency in preclinical research. Goal of these seminars is the improvement of current and future funded projects with respect to research quality. Topics include elimination of risk of bias, preregistrations, and lectures on experimental design and statistics.