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Our team, CAMARADES (Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies), uses preclinical systematic review and meta-analysis to investigate some of the challenges of translation in biomedical research. These meta-research tools provide a summary of research findings in a field and allow judgement of both the range and quality of available evidence, including the likelihood that findings are at risk of bias. The results can help us identify areas for improvement in preclinical research and inform the development of strategies to address these challenges.

Further, preclinical systematic review can help to:

  • Identify gaps in a field
  • Assess for publication bias
  • Explain discrepancies between preclinical and clinical trial results
  • Inform clinical trial design
  • Inform 3Rs (Replacement, Reduction, and Refinement of animal use in research) decisions

To learn more about preclinical systematic review and meta-analysis, see our upcoming workshops here.

To discuss your preclinical systematic review in depth with our team, contact our helpdesk: CAMARADES.berlin@charite.de

Our current research focuses primarily on the review of data from studies involving animal models of stroke and other neurological diseases and we have a range of ongoing projects:

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CAMARADES Helpdesk