BIH Translation Hub Lecture Series
Past Lectures
BIH Digital Medicine Lectures
Lecture 4: Towards Clinical Application of Neuroimage Analysis: The Brain-Age Paradigm
Lecture 4: Towards Clinical Application of Neuroimage Analysis: The Brain-Age Paradigm
On 7 October 2021 James Cole (Centre for Medical Image Computing, Computer Science, University College London, Dementia Research Centre, Queen Square Institute of Neurology, University College London) spoke about his work on the so-called "Brain-Age" paradigm, an effort to measure the biological age of the brain using neuroimaging data.
Moderation: Kerstin Ritter (Junior Professor of Computational Neuroscience at Charité, member of the Translation Hub Steering Committee).
Lecture 3: Practical Mechanisms for Generating Anonymous Data
Lecture 3: Practical Mechanisms for Generating Anonymous Data
On 26 August 2021 Khaled El Emam (School of Epidemiology and Public Health, University of Ottawa | Electronic Health Information Laboratory, Children’s Hospital of Eastern Ontario Research Institute) spoke on Practical Mechanisms for Generating Anonymous Data as part of the lecture series.
Moderation: Fabian Prasser (BIH Professor for Medical Informatics at BIH and Charité)
Lecture 2: Ensuring Machine Learning for Healthcare Works for All
Lecture 2: Ensuring Machine Learning for Healthcare Works for All
On 24 June 2021, Leo Anthony Celi (MIT Laboratory for Computational Physiology, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center) talked about exclusions and gaps in the medical knowledge system and about structural reforms to ensure that the field is both equitable and ethical by design.
Moderation: Felix Balzer (Charité, Einstein Center Digital Future))
Lecture 1: Health Data Platform Solutions
Lecture 1: Health Data Platform Solutions
Moyez Dharsee, Susan Gilbert Evans and Fan Dong from Indoc Research opened the new lecture series on 22 April 2021, describing opportunities and technologies underlying modern health data platforms and discussing sustainable models for managing, developing and operating these platforms. The focus was on the Charité/BIH Virtual Research Environment.
BIH Multi Omics Lectures
Lecture 6: Understanding the Diversity of Genetic Effects on Gene Expression in Health and Disease
On 4 October, the Translation Hub Multi-Omics together with the Schering Stiftung hosted a lecture by this years Friedmund Neumann winner Sarah Kim-Hellmuth (Helmholtz Munich and LMU).
Kim-Hellmuth talked about “Undertsanding the Diversity of Genetic Effects on Gene Expression in Health and Disease”.
The event was hosted by Jennifer Kirwan (Head of the Metabolomics Platform, Berlin Institute of Health at Charité) and Maren Isabel Fritz (Schering Stiftung).
Lecture 5: When Virchow Meets Mass Spectrometry-how Molecular Signatures May Aid Predict Disease Progression and Therapy Outcome & In Silico Prediction of Novel Therapeutic Approaches To Distinct Molecular Subtypes of HGSOC
On 23 June 2022 Oliver Klein (Lead of the BIH Imaging Mass Spectrometry Unit|KleinLab, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité (BIH)) and Hagen Kulbe (Department of Gynaecology, Charité Comprehensive Cancer Centre) talked about "When Virchow Meets Mass Spectrometry-how Molecular Signatures May Aid Predict Disease Progression and Therapy Outcome" und "In Silico Prediction of Novel Therapeutic Approaches To Distinct Molecular Subtypes of HGSOC".
Chair: Michael Schmueck-Henneresse (Group Leader, BIH Center for Regenerative Therapies (BCRT), BeCAT and Charité, Experimental Immunotherapy Group)
Lecture 4: Metabolomics: Towards Precision Medicine & Microbiota-Host Interaction in Children With Chronic Kidney Disease
On 27 January 2022 Jennifer Kirwan (Head of the Metabolomics Platform, Berlin Institute of Health at Charité) and Johannes Benjamin Holle (Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité – Universitätsmedizin Berlin) talked about "Metabolomics: Towards Precision Medicine" and "Microbiota-Host Interaction in Children With Chronic Kidney Disease".
Chair: Sofia Forslund (Group Leader Host-Microbiome Factors in Cardiovascular Disease, MDC Berlin-Buch, Max Delbrück Center for Molecular Medicine)
Lecture 3: MSTARS and New Developments for Mass Spectrometry-Driven Proteomics
Lecture 3: MSTARS and New Developments for Mass Spectrometry-Driven Proteomics
On 16 September 2021 Prof. Ulrich Keilholz (Charité Comprehensive Cancer Center - CCCC) and Dr. Philipp Mertins (Proteomics Platform, BIH and MDC) gave a tandem talk on the newly established BMBF-funded MSTARS ("Multimodal Clinical Mass Spectrometry to Target Treatment Resistance") consortium. After a brief overview, Prof. Keilholz explained the advancement of precision medicine through the establishment of a mass spectrometry-based platform in clinics. Dr. Philipp Mertins highlighted new developments for mass spectrometry-driven proteomics and presented applications in the field of hematological and head and neck cancers that also connect to a project within the translational Multi-Omics Hub of the BIH.
Moderator: Dr. Fabian Coscia (Spatial Proteomics, MDC)
Lecture 2: Primary Epithelial Cell Models for Cystic Fibrosis Studies
Lecture 2: Primary Epithelial Cell Models for Cystic Fibrosis Studies
Professor Jeffrey Beekman (University Medical Center Utrecht - UMC) continued the series of lectures on 15 October 2020 with the topic primary epithelial cell models for cystic fibrosis studies.
Lecture 1: Proteomic Analysis of Cancer Internal Heterogeneity
Lecture 1: Proteomic Analysis of Cancer Internal Heterogeneity
Professor Tami Geiger (Sackler Faculty of Medicine, Tel Aviv University) opened the new lecture series on 17 September 2020. She discussed how mass spectrometry-based proteomics can be used to understand cancer heterogeneity in breast cancer and melanoma.
Moderator: Dr. Philipp Mertins (BIH and MDC Proteomics)
BIH Clinical Translation Lectures
Lecture 2: Hub Clinical Translation - Project Update
Lecture 2: Hub Clinical Translation - Project Update
On 6 September 2021, the projects funded by the Translation Hub Clinical Translation were presented for the second time. During the event, Prof. Dr. Britta Siegmund (Charité, Medical Dept., Division of Gastroenterology, Infectiology and Rheumatology), PD Dr. med. Phillip Enghard (Charité, Medical Dept., Division of Nephrology and Internal Intensive Care Medicine) and Dr. rer.-medic. Michael Schmück-Henneresse (Berlin Institute of Health, BIH Center for Regenerative Therapies/ BCRT) presented their project results to the members of the Translation Hub Clinical Translation.
Moderation: PD Dr. Uta Höpken (MDC Lab Microenvironmental Regulation in Autoimmunity and Cancer)
BIH Organoids and Cell Engineering
Lecture 2: Novel CAR Designs and Therapeutic Applications
Lecture 2: Novel CAR Designs and Therapeutic Applications
Friedmund-Neumann-Preisträgerin und iFit-Mitglied Dr. med. Judith Feucht (University of Tuebingen and the University Children's Hospital) presented her latest research results regarding CAR T Cell Therapy on 23 September 2021. Recent advances have focused on enhancing CAR T cell functionality by calibrating strength of activation to prevent T-cell exhaustion and to augment functional persistence. Feucht presented novel CAR designs that pre-empt T cell exhaustion and enhance memory formation. Using established models of senescence, Feucht and her team could also show that novel CAR T cells eliminate senescent cells and restore tissue homeostasis in different diseases such as advanced liver fibrosis, thereby opening novel treatment strategies for solid tumors, inflammatory and age-related diseases.
Moderation: PD Dr. Annette Künkele (Charité - Klinik für Pädiatrie)
