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Our research is focused at exploring the role of the innate and adaptive immunity in the pathogenesis of non-ischemic heart failure with main interest in inflammatory cardiomyopathy and heart failure with preserved ejection fraction. The relevance of extra-cardiac versus cardiac inflammation on the pathogenesis of heart failure is investigated. In addition, our research is directed at the search for novel therapeutic targets as well as the evaluation of repurposed anti-inflammatory and immunomodulatory strategies.

Kontakt Van Linthout

Prof. Dr. Dipl. Ing. Sophie Van Linthout

Contact information
Address:Berlin Institute of Health Center for Regenerative Therapies
Föhrerstrasse 15

13353 Berlin


In view of translational research, patient materials of specific heart failure cohorts are analyzed and identified targets and therapies evaluated in experimental models.


  • NLRP3 inflammasome and S100A8/A9 alarmins
  • (cardiac) fibroblasts as inflammatory supporter cells
  • cardiosplenic axis
  • interorgan interaction 
  • mechanosensitive pathways
  • cancer therapy-related cardiotoxicity
  • immunomodulating strategies: pharmacological and cell-based


Van Linthout S - Search Results - PubMed (nih.gov)