Translational Immunocardiology
Sophie Van Linthout
Our research is focused at exploring the role of the innate and adaptive immunity in the pathogenesis of non-ischemic heart failure with main interest in inflammatory cardiomyopathy and heart failure with preserved ejection fraction. The relevance of extra-cardiac versus cardiac inflammation on the pathogenesis of heart failure is investigated. In addition, our research is directed at the search for novel therapeutic targets as well as the evaluation of repurposed anti-inflammatory and immunomodulatory strategies.
HFA
HFA Executive Board member
Coordinator of the Basic Science section
ESC
Nucleus Member
DGK
Chair-elect of the German Society of Cardiology
WG on Myocardial Function and Energetics
Focus
In view of translational research, patient materials of specific heart failure cohorts are analyzed and identified targets and therapies evaluated in experimental models.
Focus
- NLRP3 inflammasome and S100A8/A9 alarmins
- (cardiac) fibroblasts as inflammatory supporter cells
- cardiosplenic axis
- interorgan interaction
- mechanosensitive pathways
- cancer therapy-related cardiotoxicity
- immunomodulating strategies: pharmacological and cell-based
Publications
Van Linthout S - Search Results - PubMed (nih.gov)
- Van Linthout S, Stellos K, Giacca M, Bertero E, Cannata A, Carrier L, Garcia-Pavia P, Ghigo A, González A, Haugaa KH, Imazio M, Lopes LR, Most P, Pollesello P, Schunkert H, Streckfuss-Bömeke K, Thum T, Tocchetti CG, Tschöpe C, van der Meer P, van Rooij E, Metra M, Rosano GMC, Heymans S.
State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases.
Eur J Heart Fail. 2024 Nov 22. - Pesce M, Duda GN, Forte G, Girao H, Raya A, Roca-Cusachs P, Sluijter JPG, Tschöpe C, Van Linthout S.
Cardiac fibroblasts and mechanosensation in heart development, health and disease - PubMed (nih.gov)
Nat Rev Cardiol, 2022. - Matz I, Pappritz K, Springer J, Van Linthout S.
Left ventricle- and skeletal muscle-derived fibroblasts exhibit a differential inflammatory and metabolic responsiveness to interleukin-6 - PubMed (nih.gov)
Front Immunol, 2022. - Pappritz K, Lin J, El-Shafeey M, Fechner H, Kühl U, Alogna A, Spillmann F, Elsanhoury A, Schulz R, Tschöpe C1, Van Linthout S1.
Colchicine prevents disease progression in viral myocarditis via modulating the NLRP3 inflammasome in the cardiosplenic axis - PubMed (nih.gov)
ESC Heart Fail 2022 - Tschöpe C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB, Hare JM, Heidecker B, Heymans S, Kelle S, Klingel K, Parwani AS, Spillmann F, Starling RC, Tsutsui H, Seferovic P, Van Linthout S.
Myocarditis and inflammatory cardiomyopathy: current evidence and future directions - PubMed (nih.gov)
Nat Rev Cardiol 2021
Team
Team
Dr. Kathleen Pappritz
- Phone:
- 030 450 539 509/456
- E-mail:
- Kathleen.Pappritz[at]bih-charite.de
Dr. Muhammad El-Shafeey
- Phone:
- 030 450 539 509/456
- E-mail:
- Muhammad.El-Shafeey[at]bih-charite.de
Isabel Voss
- Phone:
- 030 450 539 509/456
- E-mail:
- Isabel-Marie.Voss[at]bih-charite.de
Marzena Sosnowski
- Phone:
- 030 450 539 509/456
- E-mail:
- Marzena.Sosnowski[at]bih-charite.de
Annika Koschel
- Phone:
- 030 450 539 509/456
- E-mail:
- Annika.Koschel[at]bih-charite.de
Isabell Matz
- Phone:
- 030 450 539 509/456
- E-mail:
- Isabell.Matz[at]bih-charite.de
Jack Shipman-Müller
- Phone:
- 030 450 539 509/456
- E-mail:
- Jackson.shipman-mueller[at]charite.de
Ömer Faruk Kan
- Phone:
- 030 450 539 509/456
- E-mail:
- Oemer-faruk.kan[at]charite.de