Our DFG-Emmy Noether Program-funded lab has two main focuses: First, we are developing in vivo tissue regeneration as a therapeutic strategy. Second, we aim to understand the dynamics between hematopoietic and hepatic systems in development and disease using blood-liver organoids.

The research group Model Systems for Regenerative Therapies leverages interdisciplinary approaches to interdisciplinary and translational research. Our goal is to improve our mechanistic pathophysiological understanding regarding musculoskeletal fibrosis to a level where we can offer effective solutions for clinical applications.

Infectious diseases remain one of the major causes of death world-wide. Emerging infections, such as the COVID-19 pandemic or the MPVX outbreak, but also the dramatic increase in antibiotic resistance illustrate the urgent need for novel antimicrobial interventions. Vaccines represent one of the most powerfull, safe and cost-effective tools to…

Additive manufacturing (AM) technologies could be the leverage for the generation of precise and personalized scaffold constructs enabling improved bone regeneration and remodeling outcomes. Our team strives to develop methodologies and generate knowledge that could lead to mechanistic understanding of scaffold-guided bone defect regeneration…

The objective of our research group is to acquire the basic knowledge necessary to develop new therapies against diseases affecting the liver. For that, we use stem cells to model embryonic development in vitro and to produce liver cells with an interest for cell therapy.

Tissues in the musculoskeletal system are exquisitely designed with superb mechanical properties. The tissues are also able to adapt to withstand changing mechanical conditions. The Computational Mechanobiology Group is focused on understanding these two exciting features. Using computer modeling techniques, we seek to understand the mechanical…

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Gene editing and synthetic biology: developing cell therapies for diseases with high unmet medical need.

Our research aims to understand the principles of gene regulation, how they control cell differentiation, and how these are disrupted in disease. We investigate these questions through systematic genome engineering. We create specific mutations in the genome and then study how they alter expression level, pattern, or any other aspect of gene…