The objective of our research group is to acquire the basic knowledge necessary to develop new therapies against diseases affecting the liver. For that, we use stem cells to model embryonic development in vitro and to produce liver cells with an interest for cell therapy.

We sequence cells to understand how genetic mutations form and change cell states in health and disease.

Bone is an interesting tissue from the researchers view as it is able to regenerate after injury. However, even today and with an adequate treatment 5-20% of all fractured patients experience a delayed or non-union.

Tissues in the musculoskeletal system are exquisitely designed with superb mechanical properties. The tissues are also able to adapt to withstand changing mechanical conditions. The Computational Mechanobiology Group is focused on understanding these two exciting features. Using computer modeling techniques, we seek to understand the mechanical…

The Medical Omics lab aims to improve healthcare and basic research by providing artificial intelligence-driven tools for the analysis of large biomedical datasets. For comprehensive insights in disease entities, we aim to include multiple layers of data, such as single-cell RNA sequencing, methylomics data and medical imaging. In close…

Rapid advances in molecular biology technologies are leading to a data explosion in biomedical research and clinical diagnostics. The goal of our department is to develop new and targeted ways to analyze and evaluate these data sets in order to implement innovations that benefit patients. For instance, it is desirable to make information from…

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The main research area of the Bioinformatics and Translational Genetics group is the elucidation of single gene disorders (diseases caused by DNA mutations in a single gene). We are developing user-friendly software that can be used by non-IT specialists. This allows the physicians – who know most about the patients and their disorders – to analyse…

Hypertension affects more than one billion people worldwide. As the leading risk factor for global disease burden, it contributes to more than nine million deaths annually. The mission of the Scholl group is the discovery and characterization of novel mechanisms underlying human disease. We focus on genetic causes of childhood hypertension and…

Since 2017, Martin Kircher heads the "Computational Genome Biology" working group at BIH. With the appointment as professor for regulatory genomics at the University of Lübeck and the University Hospital Schleswig-Holstein in 2022, Prof. Kircher continued his research as a BIH Fellow at the two locations. At the Berlin site, the research group is…