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Cancer frequently originates from healthy stem and precursor cells that are responsible for the continuous regeneration of tissues and organs. A stepwise acquisition of genetic and molecular abnormalities transforms healthy stem and precursor cells into potentially malignant cancer cells. While this process occurs frequently, a complex interplay between the immune system, cancer cells, and factors from the microenvironment determine whether the newly emerging cancer cells are rapidly cleared or manage to establish a fully malignant cancer. 

The Haas group develops and applies novel multimodal single-cell and spatially-resolved technologies to study the complex etiology of hematological cancers and their interaction with the immune system. Another key objective of the research group is the development of next-generation precision diagnostic and prognostic technologies, based on high-content single-cell multi-omics technologies. These newly developed technologies aim at enabling early disease detection, highly precise, personalized treatment decisions and, ultimately, therapeutic intervention before disease onset.

Selected Publications

Baccin C*, Al-Sabah J*, Velten L*, Helbling P, Grünschläger F, Hernández-Malmierca P, Nombela-Arrieta C, Steinmetz L#, Trumpp A#, Haas S#. Combined single-cell and spatial transcriptomics reveals the molecular, cellular and spatial bone marrow niche organization. Nature Cell Biology.  2020 Jan;22(1):38-48.

Haas S, Trumpp A, Milsom M. Causes and Consequences of Hematopoietic Stem Cell Heterogeneity. Cell Stem Cell. 2018 May 3;22(5):627-638.

Brocks D, Schmidt C, Daskalakis M, Li D, Li J, Jang HS, Zhang B, Laudato S, Lipka D, Schott J, Bierhoff H, Assenov Y, Helf M, Ressnerova A, Islam MS, Lindroth AM, Haas S, Essers M, Imbusch CD, Brors B, Oehme I, Witt O, Lübbert M, Mallm J, Rippe K, Will R, Weichenhan D, Stoecklin G, Gerhäuser C, Oakes CC, Wang T, Plass C. DNMT and HDAC inhibitors globally induce cryptic TSSs encoded in long terminal repeats. Nature Genetics. 2017 Jul;49(7):1052-1060.

Hirche C*, Frenz T*, Haas S*, Döring M, Borst K, Tegtmeyer P, Brizic I, Jordan S, Keyser K, Pronk E, Lin S, Messerle M, Jonjic S, Falk C, Trumpp A, Essers MAG, Kalinke U. Virus infections differentially modulate cell cycle state and functionality of long-term hematopoietic stem cells in vivo. Cell Reports. 2017 Jun 13;19(11):2345-2356.

Velten L*, Haas S*, Raffel S*, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Wolf-Hofmann K, Ho D, Huber W, Trumpp A, Essers MAG, Steinmetz LM. Human haematopoietic stem cell lineage commitment is a continuous process. Nature Cell Biology. 2017 Apr;19(4):271-281.

Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A. Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause. Cell. 2016 Feb 11;164(4):668-80.

Paul F, Arkin Y, Giladi A, Jaitin DA, Kenigsberg E, Keren-Shaul H, Winter D, Lara-Astiaso D, Gury M, Weiner A, David E, Cohen N, Lauridsen FK, Haas S, Schlitzer A, Mildner A, Ginhoux F, Jung S, Trumpp A, Porse BT, Tanay A, Amit I. Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors. Cell. 2015 Dec 17;163(7):1663-77

Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA. Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors. Cell Stem Cell. 2015 Oct 1;17(4):422-34.

Cabezas-Wallscheid N, Klimmeck D, Hansson J, Lipka DB, Reyes A, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wünsche P, Zeisberger P, Brocks D, Gu L, Herrmann C, Haas S, Essers MA, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, Trumpp A. Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis. Cell Stem Cell. 2014 Oct 2;15(4):507-22.

Klattenhoff CA, Scheuermann JC, Surface LE, Bradley RK, Fields PA, Steinhauser ML, Ding H, Butty VL, Torrey L, Haas S, Abo R, Tabebordbar M, Lee RT, Burge CB, Boyer LA. Braveheart, a long noncoding RNA required for cardiovascular lineage commitment. Cell. 2013 Jan 31;152(3):570-83.

* shared first authorship
# shared last authorship

Dr. Simon Haas

Contact information
Address:Berlin Institute for Medical Systems Biology
MDC Berlin-Mitte
Hannoversche Str. 28

10115 Berlin
E-mail:simon.haas@bihealth.de