Chronic low back pain is a significant public health problem in industrialized society. The intact spine carries the upper body and external loads, allows motion in a physiological range and protects the spinal cord. These different demands necessitate a high degree of complexity with various sources for disorders and pain. The BIH - Julius Wolff…

Defects in musculoskeletal tissues, e.g. in consequence of a trauma, do not always heal spontaneously but require surgical intervention. Biomaterials implanted into the defect region have to potential to support the healing process. We investigate the interaction between cells, their surrounding extracellular matrix and biomaterials for the…

Both mechanical and biological processes work together to determine the outcome of musculoskeletal regeneration. Whilst many of the biological factors have been identified and some even brought into clinical practice (BMP's, PDGF, IGF, etc.), the impact of the mechanical environment and the role of the immune system are only recently taken into…