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Quality AssuranceOngoing

iRISE

Improving Reproducibility In SciencE

Background / Rationale

Reproducibility is the ability to obtain results consistent with an original specific finding. Poor reproducibility is a recognized problem in scientific fields including clinical trials, preclinical research, and social sciences. Interventions have been proposed and implemented to improve reproducibility, but the effectiveness of these interventions and the underlying drivers of irreproducible research have not been investigated systematically yet.

Objectives

The project has two main objectives. Firstly, it aims to provide a comprehensive understanding of the factors that contribute to poor reproducibility in scientific research. This will involve an in-depth analysis of the drivers of reproducibility issues in areas where these are already acknowledged. Secondly, the project will conduct a detailed evaluation, including primary research, to assess the effectiveness of interventions aimed at improving reproducibility.

Methodology

The project has a two-fold approach:

First, to provide theoretical and empirical evidence that describes the effectiveness of specific interventions, the "toolbox", including:

  • Evaluating the current state-of-the-art in understanding reproducibility
  • Systematic evaluation and assessment of existing evidence
  • Systematic integration of Equity, Diversity, and Inclusion practice and culture
  • Engaging with stakeholders to prioritize and adapt practices and tools
  • Testing interventions to improve reproducibility

Second, to propose a robust, evidence-based framework for the development, assessment, and implementation of reproducibility interventions, which will serve as a roadmap for improving reproducibility in scientific research. The project will consider its findings in the broader context of open science, research integrity, trustworthiness, and research culture.

Expected results / Implications / Perspectives

The project seeks to offer concrete solutions in the form of tools and interventions that can enhance the quality, reliability, and re-usability of scientific evidence.

Expected outputs include:

  • Evidence-based implementation guides for interventions to improve reproducibility
  • Best practice guidelines for embedding Equity, Diversity, and Inclusion considerations into improving reproducibility
  • A policy briefing on evidence-based recommendations to improve reproducibility
  • A systematic online living evidence summary (SOLES) of existing interventions
  • Training resources to enable community members to implement interventions

By addressing the issue of reproducibility comprehensively and offering practical solutions, the iRISE project aims to contribute to the advancement of scientific research and promote a more robust and reliable scientific evidence base. The findings of the project will have broader relevance beyond the specific areas of science being investigated.

You can find the news about the launch of the project here. 

Funder and Cooperation Partner