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Proteomics enables the global and targeted analysis of all proteins and their functional states. Proteins are central to most biological functions within an organism and frequently alter in their abundance and in their activation status in disease. Thus, proteins can be identified as new candidates for novel diagnostic and therapeutic approaches and consequently routinely used as disease biomarkers as well as drug targets.

Ulrich Keilholz:
„Clinical Mass Spectrometry for Precision Medicine”

Prof. Ulrich Keilholz will present an overview about the newly established BMBF-funded MSTARS (“Multimodal Clinical Mass Spectrometry to Target Treatment Resistance”) consortium. The MSTARS research core in Berlin fosters precision medicine by establishing a mass spectrometry based platform in the clinics that allows standardized and high throughput analysis of patient material to support therapy recommendations.

Philipp Mertins:
"Comprehensive Discovery Proteomics Enables Biomarker and Therapeutic Target Identification"

Dr. Philipp Mertins will highlight new developments for mass spectrometry-driven proteomics in his MSTARS research group and present on applications in the field of hematological and head and neck cancers, that also connect to a project initiated within the translational Multi-omics hub of the Berlin Institute of Health (BIH).

Speaker: Prof. Dr. Ulrich Keilholz (Director of the Charité Comprehensive Cancer Center (CCCC), Professor for Comprehensive Oncology at the Charité)

Prof. Dr. Keilholz is the Director of the Charité Comprehensive Cancer Center (CCCC) and holds a full professorship for Comprehensive Oncology at the Charité -Universitätsmedizin Berlin. After completing his medical studies at the universities of Mainz, Heidelberg and Lexington (USA), he worked on his doctoral thesis at the University of Heidelberg and also fulfilled his clinical training there. After receiving his board certification for Hematology and Medical Oncology and his habilitation, Prof. Dr. Keilholz moved to Berlin to become a professor for Medical Oncology, Clinical and Molecular Tumor Immunology and to eventually assume his current professorship and position at the CCCC. His research focus is on the design and conduct of clinical oncology trials, translational research within clinical trials as well as on the development of molecular cancer counseling and precision oncology programs.

Speaker: Philipp Mertins, PhD (Group Leader and Head of Proteomics Platform, BIH and MDC)

Philipp Mertins is a group leader and head of the Proteomics Platform at Max Delbrück Center for Molecular Medicine and Berlin Institute of Health, Berlin. He is also a guest scientist at Broad Institute of MIT and Harvard, Cambridge, USA.

After completing his PhD in Biochemistry at the Max Planck Institute for Biochemistry and Technical University of Munich and working there as a postdoctoral fellow, Philipp successfully continued his scientific career at Broad Institute of MIT and Harvard as a postdoc, staff scientist and eventually as group leader. As his research interests mass spectrometry-based Proteomics, cancer and inflammation, cardiovascular diseases, signal transduction, proteogenomic data integration and biomarker and therapeutic target identification are particularly to be emphasized.

Lecture Chair: Dr. Fabian Coscia

Fabian Coscia completed his PhD thesis in the lab of Prof. Matthias Mann at the Max Planck Institute of Biochemistry in Germany, where he developed and applied proteomics methods to study cancer cell signaling at the global proteome level. Throughout his PhD he has conducted translational proteomics research to better understand the proteomic landscape of chemosensitive ovarian cancer and the role of the tumor microenvironment during cancer metastasis. For this work, he was later awarded the Walter Schulz Cancer Research Prize in 2019. As Marie Sklodowska-Curie postdoctoral fellow, Fabian moved to Denmark where he continued his translational work at the University of Copenhagen. There, he co-developed a novel AI-guided discovery proteomics pipeline combining high-resolution microscopy, machine learning and ultra-high sensitivity proteomics for next-level proteomic profiling of patient tissue specimens. Since June 2021, Fabian is heading the group Spatial Proteomics at the Max Delbrück Center for Molecular Medicine in Berlin-Buch and as part of the MSTARS consortium in Berlin, his group focuses on the development and application of mass spectrometry methods for precision oncology.

Registration

The Lecture will be held online via GoToMeeting. To participate in the Lecture, please register hereThe registration will be open until maximal participant capacity is reached.

Akkordeon

Information

When

Thursday, 16 September 2021
3 – 4 pm (Berlin, CEST)

How

via GoToMeeting
A login-link or dial-in number for the phone as well as an access code for the Lecture will be provided the evening before the event.

Registration

Please register here.
The registration will be open until maximal participant capacity is reached.

PD Dr. Mareen Matz

Referentin Exploratory Diagnostic Sciences, Forschungskoordinatorin

Kontaktinformationen
E-Mail:mareen.matz@bih-charite.de