LectureBCRT
Talk@BCRT | Jianping Fu (University of Michigan)
Vortrag zum Thema: “Bioengineering Human Embyro and Organ Models”
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Talk
“Bioengineering Human Embyro and Organ Models”
Early human development remains mysterious and difficult to study. Recent advances in developmental biology, stem cell biology and bioengineering have contributed to a significant interest in constructing controllable, stem cell-based models of human embryo and organs (embryoids / organoids). The controllability and reproducibility of these human development models, coupled with the ease of genetically modifying stem cell lines, the ability to manipulate culture conditions and the simplicity of live imaging, make them robust and attractive systems to disentangle cellular behaviors and signaling interactions that drive human development. In this talk, I will describe our effort in using human pluripotent stem cells (hPSCs) and bioengineering tools to develop controllable models of the peri-implantation embryonic development and early neural development. The peri-implantation human embryoids recapitulate early post-implantation developmental landmarks, including amniotic cavity formation, amniotic ectoderm-epiblast patterning, primordial germ cell specification, development and organization of embryonic germ layers, yolk sac formation, and primitive hematopoiesis. I will further discuss an hPSC-based, microfluidic neural tube-like structure (or µNTLS), whose development recapitulates some critical aspects of neural patterning in both brain and spinal cord regions and along both rostrocaudal and dorsoventral axes. The µNTLS is further utilized for studying development of different neuronal lineages, revealing pre-patterning of axial identities of neural crest progenitors and a role of neuromesodermal progenitors in spinal cord and trunk neural crest development. We have further developed dorsoventral patterned, microfluidic forebrain-like structures (µFBLS) with spatially segregated dorsal and ventral regions and layered apicobasal cellular organizations that mimic human embryonic brain development in pallium and subpallium areas, respectively. Together, both µNTLS and µFBLS offer 3D lumenal tissue architectures with an in vivo-like spatiotemporal cell differentiation and organization, useful for studying human neurodevelopment and disease.
About the Speaker
Dr. Jianping Fu (University of Michigan)
Dr. Jianping Fu is a Professor of Mechanical Engineering, Biomedical Engineering, and Cell & Developmental Biology at the University of Michigan. Dr. Fu’s research focuses on stem cell bioengineering, developmental bioengineering, mechanobiology, and microfluidics. Dr. Fu and his co-workers' research has contributed significantly to the emerging field of "Artificial Embryos", which was selected by MIT Technology Review as one of the “10 Breakthrough Technologies of 2018” and by Nature Methods as “the Method of 2023”. Dr. Fu is the recipient of the NSF CAREER Award, the BMES-CMBE Rising Star Award, the ACS Analytical Chemistry Young Innovator Award, the Alexander von Humboldt Foundation Friedrich Wilhelm Bessel Research Award, and numerous research awards from the University of Michigan. Dr. Fu is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE), the Royal Society of Chemistry (RSC), the American Society of Mechanical Engineers (ASME), the International Academy of Medical and Biological Engineers (IAMBE), and the Biomedical Engineering Society (BMES). Dr. Fu was a member of the International Society for Stem Cell Research (ISSCR) Guidelines Working Group from 2019 to 2021 and is currently a member of the ISSCR Publications Committee. He is a council member of the Biomedical Engineering Society Cellular and Molecular Bioengineering Special Interest Group (BMES CMBE-SIG). Dr. Fu currently serves as the Associate Editor of npj Regenerative Medicine and is an Editorial or Advisory Board Member of Cell Stem Cell, Biophysical Journal, Cell Regeneration, Mechanobiology in Medicine, and Frontiers in Cell and Developmental Biology. Additionally, Dr. Fu is a Founding Member of the Catalysts Program of EMBO Journal.
Info
When:
July 22, 2024
01:00 - 02:00 pm
Where:
BIH Center for Regenerative Therapies (BCRT)
Cranach Haus, Auditorium
Föhrer Str. 15, 13353 Berlin
Registration:
Please contact: contact@b-crt.de
