Ausgewählte Publikationen

Nachfolgend finden Sie eine Auswahl der Publikationen des BCRTs der letzten fünf Jahre.

  1. FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.

    Brevini T, Maes M, Webb GJ, John BV, Fuchs CD, Buescher G, Wang L, Griffiths C, Brown ML, Scott WE 3rd, Pereyra-Gerber P, Gelson WTH, Brown S, Dillon S, Muraro D, Sharp J, Neary M, Box H, Tatham L, Stewart J, Curley P, Pertinez H, Forrest S, Mlcochova P, Varankar SS, Darvish-Damavandi M, Mulcahy VL, Kuc RE, Williams TL, Heslop JA, Rossetti D, Tysoe OC, Galanakis V, Vila-Gonzalez M, Crozier TWM, Bargehr J, Sinha S, Upponi SS, Fear C, Swift L, Saeb-Parsy K, Davies SE, Wester A, Hagström H, Melum E, Clements D, Humphreys P, Herriott J, Kijak E, Cox H, Bramwell C, Valentijn A, Illingworth CJR; UK-PBC Consortium; Dahman B, Bastaich DR, Ferreira RD, Marjot T, Barnes E, Moon AM, Barritt AS 4th, Gupta RK, Baker S, Davenport AP, Corbett G, Gorgoulis VG, Buczacki SJA, Lee JH, Matheson NJ, Trauner M, Fisher AJ, Gibbs P, Butler AJ, Watson CJE, Mells GF, Dougan G, Owen A, Lohse AW, Vallier L, Sampaziotis F. 

    Nature, 2023 DOI: 10.1038/s41586-022-05594-0. 

  2. A 3D Human Bone and Bone Marrow-on-a-Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance.Stelzer N, Ort MJ, Händler K, Bortel E, Dimitriou IM, Textor M, Duda GN, Schoon J, Marx U, Kornak U, Winter A, Hesse B, Donner S, Hardt S, Klein O, Reinke S, Spielmann M, Geißler S.

    Adv Sci (Weinh). 2026, DOI: 10.1002/advs.202518224

  3. Cell type-specific response to curvature controls tissue growth dynamics in biomaterial pores.

    Herrera A, Molina MS, Günther R, Orellano I, Brauer E, Diederich S, Serrano A, Behncke R, Korus G, Leemhuis H, Duda GN, Petersen A. 

    Bioact Mater. 2026, doi: 10.1016/j.bioactmat

  4. Gravity-Tolerant In-Flight 3D Bioprinting Enabled by Stereolithography for Space Tissue Engineering.

    Lemke B, Kollert MR, Lam T, Thiele T, Göbel N, Köhn LR, Korus G, Kloke L, Duda GN. 

    Adv Sci (Weinh), 2026, DOI:10.1002/advs.202520715

  5. ILOBONE: A phase I/IIa randomized controlled trial to assess the safety and feasibility of local iloprost therapy for enhancing proximal humerus fracture healing- a pilot study design.

    Elazaly H, Dimitriou IM, Maleitzke T, Dahne M, Jaecker V, Maerdian S, Tafelski S, Diekhoff T, Lindner T, Akgün D, Mielke AM, Paksoy A, Amini DA, Planatscher EM, Leopold V, González-Khatib S, Köhli PC, Niemann M, Hildebrandt A, Oehme S, Palmowski Y, Paraskevaidis M, Schönnagel L, Braun SB, Pumberger M, Hardt S, Stricker S, Akyüz L, Grütz G, Schaller S, Lauterbach L, Volcksdorff M, Mödl L, Textor M, Ort M, Reinke S, Stöckle U, Perka C, Duda GN, Schmidt-Bleek K, Geissler S, Winkler T.J 

    Orthop Surg Res. 2025, DOI: 10.1186/s13018-025-05865-2.

  6. Water and ions binding to extracellular matrix drives stress relaxation, aiding MRI detection of swelling-associated pathology.

    Kollert MR, Krämer M, Brisson NM, Schemenz V, Tsitsilonis S, Qazi TH, Fratzl P, Vogel V, Reichenbach JR, Duda GN.

    Nat Biomed Eng, 2025, DOI: 10.1038/s41551-025-01369-w

  7. Acquisition of epithelial plasticity in human chronic liver disease.

    Gribben C, Galanakis V, Calderwood A, Williams EC, Chazarra-Gil R, Larraz M, Frau C, Puengel T, Guillot A, Rouhani FJ, Mahbubani K, Godfrey E, Davies SE, Athanasiadis E, Saeb-Parsy K, Tacke F, Allison M, Mohorianu I, Vallier L. Nature. 2024 doi: 10.1038/s41586-024-07465-2.

  8. The enhancer landscape predetermines the skeletal regeneration capacity of stromal cells Hochmann, S.; Ou, K.; Poupardin, R.; Mittermeir, M.; Textor, M.; Ali, S.; Wolf, M.; Ellinghaus, A.; Jacobi, D.; Elmiger, J. A. J.; Donsante, S.; Riminucci, M.; Schäfer, R.; Kornak, U.; Klein, O.; Schallmoser, K.; Schmidt-Bleek, K.; Duda, G. N.; Polansky, J. K.; Geissler, S.; Strunk, D.

    Science Translational Medicine, 2023, DOI:10.1126/scitranslmed.abm7477

  9. HLA matching or CRISPR editing of HLA class I/II enables engraftment and effective function of allogeneic human regulatory T cell therapy in a humanized mouse transplantation model

    McCallion, O.; Du, W.; Glaser, V.; Milward, K.; Short, S.; Bilici, M.; Cross, A.; Stark, H.; Franke, C.; Kath, J.; Valkov, M.; Yang, M.; Amini, L.; Künkele, A.; Polansky, J. K.; Schmueck-Henneresse, M.; Volk, H.-D.; Reinke, P.; Wagner, D. L.; Hester, J.; Issa, F.

    Nature Communications, 2025, DOI:10.1038/s41467-025-64945-3

  10. Lung tumouroids as a testing platform for precision CAR T cell therapy         

    Ehlen, L.; Farrera-Sal, M.; Szyska, M.; Arndt, J.; Schallenberg, S.; Scholz, C.; Yang, M.; Vollbrecht, C.; Löwa, A.; Friedrich, R.; Mai, M.; Peter, L.; Picht, S.; Schulenberg, S.; Geray, D.; Korus, G.; Sommerfeld, A.; Treue, D.; Strauchmann, J.; Elsner, A.; Kath, J.; Fernandez Vallone, V.; Joosten, M.; Klatte-Schulz, F.; Petersen, A.; Stachelscheid, H.; Wagner, D. L.; Spies, C.; Rückert, J.-C.; Hocke, A. C.; Polansky, J. K.; Stark, R.; Klein, O.; Schmueck-Henneresse, M.

    Nature Biomedical Engineering, 2026, DOI:10.1038/s41551-025-01594-3

  11. Preparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion

    Amini, L.; Silbert, S. K.; Maude, S. L.; Nastoupil, L. J.; Ramos, C. A.; Brentjens, R. J.; Sauter, C. S.; Shah, N. N.; Abou-El-Enein, M.       

    Nature Reviews Clinical Oncology, 2022, DOI:10.1038/s41571-022-00607-3

  12. The cortical microenvironment drives early immune organization and controls early osteoclastogenesis in bone healing          

    Noom, A.; Oktay, H. Z.; Morgan, D. M.; Kroh, S.; Kasapi, A.; Ellinghaus, A.; Kochan, M.; Bolaji, O.; Uecker, R.; Günther, R.; Bianchi, M. P.; Bucher, C. H.; Hildebrandt, A.; Haas, S.; Schmidt-Bleek, K.; Triantafyllopoulou, A.; Hauser, A. E.; Sawitzki, B.; Duda, G. N.

    Nature Communications, 2026, DOI:10.1038/s41467-026-77196-7

  13. The rise of patient avatars in precision oncology   

    Ehlen, L.; Schmueck-Henneresse, M. 

    Nature Biotechnology, 2024, DOI:    10.1038/s41587-024-02335-8

  14. A comprehensive molecular profiling approach reveals metabolic alterations that steer bone tissue regeneration          

    Löffler, J.; Noom, A.; Ellinghaus, A.; Dienelt, A.; Kempa, S.; Duda, G. N.

    Communications Biology, 2023, DOI:10.1038/s42003-023-04652-1

  15. Adoptive transfer of ex vivo expanded regulatory T cells improves immune cell engraftment and therapy-refractory chronic GvHD

    Landwehr-Kenzel, S.; Müller-Jensen, L.; Kuehl, J.-S.; Abou-El-Enein, M.; Hoffmann, H.; Muench, S.; Kaiser, D.; Roemhild, A.; von Bernuth, H.; Voeller, M.; Schmueck-Henneresse, M.; Gruhn, B.; Stervbo, U.; Babel, N.; Volk, H.-D.; Reinke, P. 

    Molecular Therapy, 2022, DOI:10.1016/j.ymthe.2022.02.025

  16. Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells

    Kath, J.; Du, W.; Pruene, A.; Braun, T.; Thommandru, B.; Turk, R.; Sturgeon, M. L.; Kurgan, G. L.; Amini, L.; Stein, M.; Zittel, T.; Martini, S.; Ostendorf, L.; Wilhelm, A.; Akyüz, L.; Rehm, A.; Höpken, U. E.; Pruß, A.; Künkele, A.; Jacobi, A. M.; Volk, H.-D.; Schmueck-Henneresse, M.; Stripecke, R.; Wagner, D. L.          

    Molecular Therapy – Methods & Clinical Development, 2022, DOI:10.1016/j.omtm.2022.03.018

  17. Targeting TGF-β signaling, oxidative stress, and cellular senescence rescues osteoporosis in gerodermia osteodysplastica       

    Chan, W. L.; Bucher, C. H.; Goldes, J.; Ma, A. C.; Steiner, M.; Willie, B. M.; Mundlos, S.; Kornak, U.        

    Aging Cell, 2024, DOI:10.1111/acel.14322

  18. State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases

    Van Linthout, S.; Stellos, K.; Giacca, M.; Bertero, E.; Cannata, A.; Carrier, L.; Garcia-Pavia, P.; Ghigo, A.; González, A.; Haugaa, K. H.; Imazio, M.; Lopes, L. R.; Most, P.; Pollesello, P.; Schunkert, H.; Streckfuss-Bömeke, K.; Thum, T.; Tocchetti, C. G.; Tschöpe, C.; van der Meer, P.; van Rooij, .; Metra, M.; Rosano, G. M. C.; Heymans, S.

    European Journal of Heart Failure, 2025, DOI:10.1002/ejhf.3516

  19. Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors      

    Kotsaris, G.; Qazi, T. H.; Bucher, C. H.; Zahid, H.; Pöhle-Kronawitter, S.; Ugorets, V.; Jarassier, W.; Börno, S.; Timmermann, B.; Giesecke-Thiel, C.; Economides, A. N.; Le Grand, F.; Vallecillo-García, P.; Knaus, P.; Geissler, S.; Stricker, S.       

    Regenerative Medicine, 2023, DOI:10.1038/s41536-023-00291-6

  20. Bio-instructive hydrogel expands the paracrine potency of mesenchymal stem cells

    Drzeniek, N. M.; Mazzocchi, A.; Schlickeiser, S.; Forsythe, S. D.; Moll, G.; Geißler, S.; Reinke, P.; Gossen, M.; Gorantla, V. S.; Volk, H.-D.; Soker, S.      

    Biofabrication, 2021, DOI:10.1088/1758-5090/ac0a32

  21. Generation of Regulatory T Cells From Human Memory CD4+ T Cells by Upregulation of Naked Cuticle Homolog 

    He, J.; Ou, K.; Schmueck-Henneresse, M.; Specker, E.; Paul, J.; Nazare, M.; von Kries, J. P.; Polansky, J. K.; Hamann, A.; Frischbutter, S.         

    European Journal of Immunology, 2025, DOI:10.1002/eji.70018

  22. Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors        

    Launspach, M.; Macos, J.; Afzal, S.; Hohmann, J.; Appis, M. L.; Pilgram, M.; Beez, S.; Ohlendorf, E.; van der Ven, C. F. T.; Lachiheb, C.; Töws, K.; Andersch, L.; Jens, M.; Zirngibl, F.; Kath, J.; Stecklum, M.; Rodriguez-Fos, E.; Anders, K.; Wagner, D. L.; Henssen, A. G.; Kühn, R.; Eggert, A.; Künkele, A.   

    Nature Communications, 2025, DOI:10.1038/s41467-025-67328-w