Publikationen der AG Medizininformatik

2026

Gräßel L, Strantz C, Prochaska E, Debertshäuser T, Rogge A, Bäcker S, et al. PROs als Kompass der intersektoralen onkologischen Versorgung–von der Praxis in das MTB und zurück. Die Onkologie. 2026:1-7.

Abu Attieh H, Halilovic M, Kerkouche R, Rahimian S, Wang HP, Rehms R, et al. An exploratory survey study toward a conceptual framework for structuring the integration of privacy-enhancing technologies in federated learning and analytics. IEEE Access. 2026.

Halilovic M, Meurers T, Alibone M, Ludwig M, Tiwald P, Sieberg-Riedel N, et al. A case study comparing anonymized and synthetic health insurance claims data for medication safety assessments. NPJ Digital Medicine. 2026.

Roth M, Plessen CY, Liegl G, Fischer F, Koeppen LS, Vajkoczy P, et al. Enhancing High‐Resolution Assessment in Pain Disorders: Development of an Adaptive Real‐Time Version of the Pain Catastrophizing Scale. European Journal of Pain. 2026;30(4):e70266.

Escudié JB, Barnes B, Meisegeier S, Kraywinkel K, Prasser F, Körber N. Evaluating quality in synthetic data generation for large tabular health datasets. arXiv preprint arXiv:2604.15961. 2026.

Jacobs M, Goudarzi S, Stücke J, Röhm R, Kanninen T, Oinonen T, et al. Selecting medical research data platforms for translational biomedical research: a five-tier overview and requirement-weighted assessment framework. Frontiers in Digital Health. 2026;8:1814015.

Wündisch E, Palant A, Khodarkovsky L, Neumann F, Weber J, Prasser F. Scaling Electronic Consent for Research Integrated into Clinical Routine Processes. Studies in Health Technology and Informatics. 2026;336:1400-1404.

Zilske C, Seidel F, Cortés JS, Müller A, Brunecker P, Prasser F. A FHIR-Based Dashboard as an Integrated Research Patient Record and Quality Assurance Tool. Studies in Health Technology and Informatics. 2026;336:1486-1490.

Overton P, Kiel A, Semler SC, Prasser F, Kussel T, Ganslandt T, et al. Accurate Yet Privacy-Preserving Determination of Case Numbers Across German University Hospital Health Data. Studies in Health Technology and Informatics. 2026;336:1425-1429.

Abu Attieh H, Halilovic M, Herr MDAB, Hieber D, Placzek P, Roehl A, et al. A Maturity Model for the Enforcement of PETs in Federated Settings. Studies in Health Technology and Informatics. 2026;336:1593-1594.

Meurers T, Halilovic M, Abu Attieh H, Despraz J, Kaabachi B, Otte K, et al. Unequal Flows? Economic Dimensions of Sharing Anonymized Data in Biomedical Research. Studies in Health Technology and Informatics. 2026;2061 - 2065.

Abu Attieh H, Jolly JK, Pallaoro P, Herr MDAB, Schreiweis B, Kirsten T, et al. Setting up a DataSHIELD Hub for the German Medical Informatics Initiative: Challenges and Lessons Learned. Studies in Health Technology and Informatics. 2026;336:1491-1495.

de Arruda Botelho Herr M, Placzek P, Abu Attieh H, Schultz B, Hieber D, Röhl A, et al. Enabling Privacy-Preserving Federated Learning in Healthcare: The FLAME Architecture and Policy Framework. Studies in Health Technology and Informatics. 2026;336:1589-1590.

Hirsch A, Ten FW, Krueger KS, Geyer R, Roeschl T, Groeschel M, et al. The Multimodal Anonymizer: a fully local multi-agent AI system for medical data deidentification. medRxiv. 2026:2026.05.28.26353952.

2025

Meurers T, Halilovic M, Otte K, Despraz J, Kaabachi B, Kulynych B, et al. Phantom Anonymization: Adversarial testing for membership inference risks in anonymized health data. Computers in Biology and Medicine. 2025;196:110738.

Tai KH, Müller M, Mansmann U, Armond ACV, Decullier E, Le Louarn A, et al. Key concepts in clinical epidemiology: FAIRification of biomedical research data. Journal of Clinical Epidemiology. 2025:111920.

Baum L, Johns M, Müller A, Domhardt M, Prasser F. Real-World Data Integration in Practice: Why Communication with Domain Experts is Key. MEDINFO 2025—Healthcare Smart × Medicine Deep. 2025:1582-1583.

Meurers T, Otte K, Abu Attieh H, Briki F, Halilovic M, Kaabachi B, et al. Evaluation of Anonymization Practices Among Popular Repositories of Data for Biomedical Research. Medinfo 2025—Healthcare Smart × Medicine Deep: Proceedings of the 20th World Congress on Medical and Health Informatics. 2025:209-213.

Müller A, Wirth FN, Prasser F. An Open Source Benchmark for Pseudonymization Services in Translational Research. MEDINFO 2025—Healthcare Smart × Medicine Deep. 2025:219-223.

Abu Attieh H, Müller A, Prasser F. Pseudonymization Algorithms for Medical Research: Adoption and Trends. Medinfo 2025—Healthcare Smart × Medicine Deep: Proceedings of the 20th World Congress on Medical and Health Informatics. 2025:214-218.

Lohr C, Faller J, Riedel A, Nguyen HM, Wolfien M, Hofenbitzer J, et al. GeMTeX’s De-Identification in Action: Lessons Learned & Devil’s Details. German Medical Data Sciences 2025: GMDS Illuminates Health. 2025:274-282.

Halilovic M, Otte K, Meurers T, Alibone M, Ludwig M, Riedel N, et al. Anonymization of health insurance claims data for medication safety assessments. German Medical Data Sciences 2025: GMDS Illuminates Health: Proceedings of the 70th Annual Meeting of the German Association of Medical Informatics, Biometry, and Epidemiology e.V. (GMDS), Jena, Germany, 7-11 September 2025. 2025:283-291.

Francis P, Jurak G, Leskošek B, Otte K, Prasser F. Comparison of three anonymization tools for a Health Fitness Study. Scientific Data. 2025;12(1):1548.

Pineda-Moncusí M, Rekkas A, Pérez AM, Leis A, Gomez CL, Fey E, et al. Changes in use and utilisation patterns of drugs with reported shortages between 2010 and 2024 in Europe and North America: a network cohort study. The Lancet Public Health. 2025;10(10):e835-e847.

Müller A, Wündisch E, Wirth FN, Meier zu Ummeln S, Weber J, Prasser F. The Advanced Confidentiality Engine as a Scalable Tool for the Pseudonymization of Biomedical Data in Translational Settings: Development and Usability Study. Journal of Medical Internet Research. 2025;27:e71822.

Intemann T, Kaulke K, Kipker DK, Lettieri V, Stallmann C, Schmidt CO, et al. Verbesserung des Record Linkage für die Gesundheitsforschung in Deutschland–wie können Defizite behoben werden? Bundesgesundheitsblatt—Gesundheitsforschung—Gesundheitsschutz. 2025:1-10.

Warnecke Y, Kuhn M, Bley LI, Preciado-Marquez D, Otte K, Pasquier A, et al. Transforming Oncology Data for Artificial Intelligence: Leveraging oBDS for Scalable Medical Research [Meeting abstract]. In: Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie, editors. 70. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS); 2025 Sep 7-11; Jena. Düsseldorf: German Medical Science GMS Publishing House; 2025. DocAbstr. 139. doi:10.3205/25gmds064.

Franz M, Milicevic V, Behnke M, Peña Diaz LA, Rüther FD, Aghdassi SJ, et al. A Demonstrator Dashboard for Surveillance of Hospital-Onset Bacteremia within the Medical Informatics Initiative [Meeting abstract]. In: Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie, editors. 70. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS); 2025 Sep 7-11; Jena. Düsseldorf: German Medical Science GMS Publishing House; 2025. DocAbstr. 51. doi:10.3205/25gmds158.

Zilske C, Seidel F, Lewash Y, Brunecker P, Prasser F. A FHIR dashboard to provide an electronic research patient record and quality assurance tool for Data Integration Centers within the Medical Informatics Initiative [Meeting abstract]. In: Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie, editors. 70. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS); 2025 Sep 7-11; Jena. Düsseldorf: German Medical Science GMS Publishing House; 2025. DocAbstr. 96. doi:10.3205/25gmds176.

Halilovic M, Meurers T, Otte K, Prasser F. Parallel privacy preservation through partitioning (P4): a scalable data anonymization algorithm for health data. BMC Med Inform Decis Mak. 2025 Mar 12;25(1):129. doi: 10.1186/s12911-025-02959-z.

Gräßel L, Wolfien M, Strantz C, Prochaska E, Debertshäuser T, Rogge A, ... Prasser F et al. The Promise of PROs in Molecular Tumor Boards [Internet]. OSF Preprints; 2025. Available from: osf.io/8z47g_v1.

Adams T, Birkenbihl C, Otte K, Ng HG, Rieling JA, Näher AF, Sax U, Prasser F, Fröhlich H; Alzheimer’s Disease Neuroimaging Initiative. On the fidelity versus privacy and utility trade-off of synthetic patient data. iScience. 2025 Apr 14;28(5):112382. doi: 10.1016/j.isci.2025.112382.

Meurers T, Otte K, Abu Attieh H, Briki F, Despraz J, Halilovic M, Kaabachi B, Milicevic V, Müller A, Papapostolou G, Wirth FN, Raisaro JL, Prasser F. A quantitative analysis of the use of anonymization in biomedical research. NPJ Digit Med. 2025 May 14;8(1):279. doi: 10.1038/s41746-025-01644-9.

Nanevski I, Mohebi M, Jäger, S, Otte K, Schulte-Althoff M, Prasser F, ..., Biessmann F. (2025). Evaluating the Quality of Synthetic Data in Health Care.

Abu Attieh H, Müller A, Wirth FN, Prasser F. Pseudonymization tools for medical research: a systematic review. BMC Med Inform Decis Mak. 2025 Mar 12;25(1):128. doi: 10.1186/s12911-025-02958-0.

Pilgram L, Dankar FK, Drechsler J, Elliot M, Domingo-Ferrer J, Francis P, ..., Prasser F, El Emam K. A Consensus Privacy Metrics Framework for Synthetic Data. arXiv preprint arXiv:2503.04980 2025.

Rogge AA, Mukowski-Kickhöfel R, Boeker M, ... Prasser F. Integrating the Patient Perspective into Healthcare and Real-World Evidence: The Multi-site, Cross-Disease, Patient-Centered Outcomes Research Project in the Medical Informatics Initiative (PCOR-MII). J Healthc Inform Res (2025). doi: 10.1007/s41666-025-00187-8.

Kaabachi B, Despraz J, Meurers T, Otte K, Halilovic M, Kulynych B, Prasser F, Raisaro JL. A scoping review of privacy and utility metrics in medical synthetic data. NPJ Digit Med. 2025 Jan 27;8(1):60. doi: 10.1038/s41746-024-01359-3.

Baum L, Johns M, Meurers T, Otte K, Wirth FN, Prasser F. Hackathon Insights: The Critical Role of Custom Data Selection and Aggregation in Longitudinal Health Analytics. Stud Health Technol Inform. 2025 May 15;327:477-481. doi: 10.3233/SHTI250383.

Müller A, Prasser F. Systematization of Pseudonymization Algorithms for Health Data. Stud Health Technol Inform. 2025 May 15;327:765-766. doi: 10.3233/SHTI250458.

Johns M, Baum L, Prasser F. Tracking provenance in clinical data warehouses for quality management. Int J Med Inform. 2025 Jan;193:105690. doi: 10.1016/j.ijmedinf.2024.105690.

2024

Johann TI, Otte K, Prasser F, Dieterich C. Anonymize or synthesize? Privacy-preserving methods for heart failure score analytics. Eur Heart J Digit Health. 2024 Nov 20;6(1):147-154. doi: 10.1093/ehjdh/ztae083.

Francis P, Jurak G, Leskošek B, Otte K, Prasser F. Data Anonymization for Open Science: A Case Study. medRxiv, 2024.12.16.24319068.

Puskaric M, Attieh HA, Prasser F et al. Data infrastructure for integrating clinical data in the large-scale international ORCHESTRA cohort: from data import to federated analysis. IEEE International Conference on Big Data (BigData), 7998-8004, 2024.

Baum L, Johns M, Müller A, Abu Attieh H, Prasser F. HERALD: A domain-specific query language for longitudinal health data analytics. Int J Med Inform. 2024 Dec;192:105646. doi: 10.1016/j.ijmedinf.2024.105646.

Daniel Boie S, Meyer-Eschenbach F, Schreiber F, Giesa N, Barrenetxea J, Guinemer C, Haufe S, Krämer M, Brunecker P, Prasser F, Balzer F. A scalable approach for critical care data extraction and analysis in an academic medical center. Int J Med Inform. 2024 Dec;192:105611. doi: 10.1016/j.ijmedinf.2024.105611.

Baum L, Müller A, Johns M, Abu Attieh H, Halilovic M, Milicevic V, Neves DT, Otte K, Pasquier A, Wirth FN, Segelitz P, Schönrath K, Weber JE, Prasser F. An interactive dashboard for analyzing user interaction patterns in the i2b2 clinical data warehouse. BMC Med Inform Decis Mak. 2024 Nov 11;24(1):333. doi: 10.1186/s12911-024-02748-0.

Pineda-Moncusí M, Rekkas A, Pérez ÁM, Leis A, Lopez Gomez C, Fey E, ..., Prasser F et al. Trends of use of drugs with suggested shortages and their alternatives across 52 real world data sources and 18 countries in Europe and North America. medRxiv, 2024.08.28.24312695.

Al-Dhamari I, Abu Attieh H, Prasser F. Synthetic datasets for open software development in rare disease research. Orphanet J Rare Dis. 2024 Jul 15;19(1):265. doi: 10.1186/s13023-024-03254-2.

Zoch M, Gierschner C, Andreeff AK, Henke E, Sedlmayr M, Müller G, Tippmann J, Hebestreit H, Choukair D, Hoffmann GF, Fritz-Kebede F, Toepfner N, Berner R, Biergans S, Verbücheln R, Schaaf J, Fleck J, Wirth FN, Schepers J, Prasser F. Secondary use of patient data within decentralized studies using the example of rare diseases in Germany: A data scientist's exploration of process and lessons learned. Digit Health. 2024 Aug 10;10:20552076241265219.

Kühnel L, Schneider J, Perrar I, Adams T, Moazemi S, Prasser F, Nöthlings U, Fröhlich H, Fluck J. Synthetic data generation for a longitudinal cohort study - evaluation, method extension and reproduction of published data analysis results. Sci Rep. 2024 Jun 22;14(1):14412. doi: 10.1038/s41598-024-62102-2.

Wirth FN, Abu Attieh H, Prasser F. OHDSI-compliance: a set of document templates facilitating the implementation and operation of a software stack for real-world evidence generation. Front Med (Lausanne). 2024 May 16;11:1378866. doi: 10.3389/fmed.2024.1378866.

Dellacasa C, Ortali M, Rossi E, Abu Attieh H, Osmo T, Puskaric M, Rinaldi E, Prasser F, Stellmach C, Cataudella S, Agarwal B, Mata Naranjo J, Scipione G. An innovative technological infrastructure for managing SARS-CoV-2 data across different cohorts in compliance with General Data Protection Regulation. Digit Health. 2024 May 15;10:20552076241248922. doi: 10.1177/20552076241248922.

Ammon D, Kurscheidt M, Buckow K, Kirsten T, Löbe M, Meineke F, Prasser F, Saß J, Sax U, Stäubert S, Thun S, Wettstein R, Wiedekopf JP, Wodke JAH, Boeker M, Ganslandt T. Interoperability Working Group: core dataset and information systems for data integration and data exchange in the Medical Informatics Initiative. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2024 Jun;67(6):656-667. doi: 10.1007/s00103-024-03888-4.

Marschollek M, Marquet M, Reinoso Schiller N, Naim J, Aghdassi SJS, Behnke M, Ehrenberg S, von Landesberger T, Misailovski M, Prasser F, Scherag A, Schlueter D, Wulff A; RISK PRINCIPE Study Group; Pletz M, Scheithauer S. Automated surveillance and risk prediction with the aim of risk-stratified infection control and prevention (RISK PRINCIPE). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2024 Jun;67(6):685-692. doi: 10.1007/s00103-024-03882-w.

Kirsten T, Kleinert P, Gebhardt M, Drepper J, Andreeff AK, Prasser F, Kohlbacher O. Foundations for the scientific use of extensive health care data in Germany-results of the Data Sharing working group of the Medical Informatics Initiative. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2024 Jun;67(6):648-655. doi: 10.1007/s00103-024-03880-y.

Pilgram L, Meurers T, Malin B, Schaeffner E, Eckardt KU, Prasser F; GCKD Investigators. The Costs of Anonymization: Case Study Using Clinical Data. J Med Internet Res. 2024 Apr 24;26:e49445. doi: 10.2196/49445.

Abu Attieh H, Neves DT, Guedes M, Mirandola M, Dellacasa C, Rossi E, Prasser F. A Scalable Pseudonymization Tool for Rapid Deployment in Large Biomedical Research Networks: Development and Evaluation Study. JMIR Med Inform. 2024 Apr 23;12:e49646. doi: 10.2196/49646.

Zenker S, Strech D, Jahns R, Müller G, Prasser F, Schickhardt C, Schmidt G, Semler SC, Winkler E, Drepper J. Nationally standardized broad consent in practice: initial experiences, current developments, and critical assessment. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2024 Jun;67(6):637-647. doi: 10.1007/s00103-024-03878-6.

Wündisch E, Hufnagl P, Brunecker P, Meier Zu Ummeln S, Träger S, Kopp M, Prasser F, Weber J. Development of a Trusted Third Party at a Large University Hospital: Design and Implementation Study. JMIR Med Inform. 2024 Apr 18;12:e53075. doi: 10.2196/53075.

Prasser F, Riedel N, Wolter S, Corr D, Ludwig M. Artificial intelligence and secure use of health data in the KI-FDZ project: anonymization, synthetization, and secure processing of real-world data. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2024 Feb;67(2):171-179. doi: 10.1007/s00103-023-03823-z.

Scholz C, Schmigalle P, Plessen CY, Liegl G, Vajkoczy P, Prasser F, Rose M, Obbarius A. The effect of self-management techniques on relevant outcomes in chronic low back pain: A systematic review and meta-analysis. Eur J Pain. 2024 Apr;28(4):532-550. doi: 10.1002/ejp.2221.

2023

Scholz C, Schmigalle P, Plessen CY, Liegl G, Vajkoczy P, Prasser F, Rose M, Obbarius A. The effect of self-management techniques on relevant outcomes in chronic low back pain: A systematic review and meta-analysis. Eur J Pain. 2023 Dec 9. doi.org/10.1002/ejp.2221.

Intemann T, Kaulke K, Kipker DK, Lettieri V, Stallmann C, Schmidt CO, Geidel L, Bialke M, Hampf C, Stahl D, Lablans M, Franke M, Kraywinkel KP, Kieschke J, Bartholomäus S, Näher AF, Tremper G, Lambarki M, March S, Prasser F, Haber AC, Drepper J, Schlünder I, Kirsten T, Pigeot I, Sax U, Buchner B, Ahrens W, Semler SC. Verbesserung des Record Linkage für die Gesundheitsforschung in Deutschland. arXiv preprint arXiv:2312.10093. 2023. DOI: 10.4126/FRL01-006461895.

Krefting D, Arzt M, Maurer JT, Penzel T, Prasser F, Sedlmayr M, et al. Sleep apnea healthcare management in dynamically changing times: Unlocking the potential of digitalization for better care of obstructive sleep apnea—in Germany and beyond. Somnologie. 2023;1-7. doi.org/10.1007/s11818-023-00428-1.

Kamdje Wabo G, Prasser F, Gierend K, Siegel F, Ganslandt T. Data Quality- and Utility-Compliant Anonymization of Common Data Model-Harmonized Electronic Health Record Data: Protocol for a Scoping Review. JMIR Res Protoc. 2023 Aug 11;12:e46471. doi:10.2196/46471.

Kühnel L, Schneider J, Perrar I, Adams T, Prasser F, Nöthlings U, et al. Synthetic data generation for a longitudinal cohort study - Evaluation, method extension and reproduction of published data analysis results. arXiv preprint arXiv:2305.07685. 2023. doi.org/10.48550/arXiv.2305.07685.

Holub P, Müller H, Bíl T, Pireddu L, Plass M, Prasser F, Schlünder I, Zatloukal K, Nenutil R, Brázdil T. Privacy risks of whole-slide image sharing in digital pathology. Nat Commun. 2023 May 4;14(1):2577. doi: 10.1038/s41467-023-37991-y. PMID: 37142591; PMCID: PMC10160114.

Müller A, Christmann LS, Kohler S, Eils R, Prasser F. Machine Learning for Medical Data Integration. Stud Health Technol Inform. 2023 May 18;302:691-695. doi: 10.3233/SHTI230241. PMID: 37203471.

Baum L, Johns M, Poikela M, Möller R, Ananthasubramaniam B, Prasser F. Data integration and analysis for circadian medicine. Acta Physiol (Oxf). 2023 Apr;237(4):e13951. doi: 10.1111/apha.13951. Epub 2023 Feb 28. PMID: 36790321.

Johns M, Meurers T, Wirth FN, Haber AC, Müller A, Halilovic M, Balzer F, Prasser F. Data Provenance in Biomedical Research: Scoping Review. J Med Internet Res. 2023 Mar 27;25:e42289. doi: 10.2196/42289. PMID: 36972116; PMCID: PMC10132013.

Pilgram L, Eberwein L, Jensen BO, Jakob CEM, Koehler FC, Hower M, Kielstein JT, Stecher M, Hohenstein B, Prasser F, Westhoff T, de Miranda SMN, Vehreschild MJGT, Lanznaster J, Dolff S; LEOSS study group. SARS-CoV-2 infection in chronic kidney disease patients with pre-existing dialysis: description across different pandemic intervals and effect on disease course (mortality). Infection. 2023 Feb;51(1):71-81. doi: 10.1007/s15010-022-01826-7. Epub 2022 Apr 29. PMID: 35486356; PMCID: PMC9052729.

Pilgram L, Schäffner E, Eckardt KU, Prasser F; GCKD Investigators. Utility-Preserving Anonymization in a Real-World Scenario: Evidence from the German Chronic Kidney Disease (GCKD) Study. Stud Health Technol Inform. 2023 May 18;302:28-32. doi: 10.3233/SHTI230058. PMID: 37203603.

Strech D, Haven T, Madai VI, Meurers T, Prasser F. Generating evidence on privacy outcomes to inform privacy risk management: A way forward? J Biomed Inform. 2023 Jan;137:104257.

Mansmann U, Locher C, Prasser F, Weissgerber T, Sax U, Posch M, Decullier E, Cristea IA, Debray TPA, Held L, Moher D, Ioannidis JPA, Ross JS, Ohmann C, Naudet F. Implementing clinical trial data sharing requires training a new generation of biomedical researchers. Nat Med. 2023 Feb 2.

2022

Koll CEM, Hopff SM, Meurers T, Lee Ch, Kohls M, Stellbrink C, Thibeault C, Reinke L, Steinbrecher S, Schreiber S, Mitrov L, Frank S, Miljukov O, Erber J, Hellmuth JC, Reese JP, Steinbeis F, Bahmer T, Hagen M, Meybohm P, Hansch S, Vadász I, Krist L, Jiru-Hillmann S, Prasser F, Vehreschild JJ, NAPKON Study Group. Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients. Scientific Data, 2022 Dec 21;9(1):776. doi: 10.1038/s41597-022-01669-9.

Wirth FN, Kussel T, Müller A, Hamacher K, Prasser F. EasySMPC: a simple but powerful no-code tool for practical secure multiparty computation. BMC Bioinformatics 23 (1), 1-17, 2022. https://doi.org/10.1186/s12859-022-05044-8.

Haber AC, Sax U, Prasser F. Open Tools for Quantitative Anonymization of Tabular Phenotype Data: Literature Review. Brief Bioinformatics. 2022; bbac440. doi: 10.1093/bib/bbac440.

Kaabachi B, Despraz J, Meurers T, Prasser F, Raisaro JL. Generation and Evaluation of Synthetic Data in a University Hospital Setting. Stud Health Technol Inform. 2022 May 25;294:141-142. doi: 10.3233/SHTI220420. PMID: 35612040.

Katsch F, Hussein R, Sabutsch S, Prenner H, Prasser F, Stamm T, Duftschmid G. Extending the Austrian National EHR System with Patient-Reported Outcome Data. Stud Health Technol Inform. 2022 May 25;294:561-562. doi: 10.3233/SHTI220523. PMID: 35612144.

Prokosch HU, Bahls T, Bialke M, Eils J, Fegeler C, Gruendner J, Haarbrandt B, Hampf C, Hoffmann W, Hund H, Kampf M, Kapsner LA, Kasprzak P, Kohlbacher O, Krefting D, Mang JM, Marschollek M, Mate S, Müller A, Prasser F, Sass J, Semler S, Stenzhorn H, Thun S, Zenker S, Eils R. The COVID-19 Data Exchange Platform of the German University Medicine. Stud Health Technol Inform. 2022 May 25;294:674-678. doi: 10.3233/SHTI220554. PMID: 35612174.

Neves DT, Alves J, Naik MG, Proença AJ, Prasser F. From missing data imputation to data generation. Journal of Computational Science 2022:101640. doi.org/10.1016/j.jocs.2022.101640.

Sommer KK, Amr A, Bavendiek U, Beierle F, Brunecker P, Dathe H, Eils J, Ertl M, Fette G, Gietzelt M, Heidecker B, Hellenkamp K, Heuschmann P, Hoos JDE, Kesztyüs T, Kerwagen F, Kindermann A, Krefting D, Landmesser U, Marschollek M, Meder B, Merzweiler A, Prasser F, Pryss R, Richter J, Schneider P, Störk S, Dieterich C. Structured, Harmonized, and Interoperable Integration of Clinical Routine Data to Compute Heart Failure Risk Scores. Life 2022; 12(5):749. doi.org/10.3390/life12050749.

Pilgram L, Eberwein L, Jensen BEO, Jakob CE, Koehler FC, Hower M, Kielstein JT, Stecher M, Hohenstein B, Prasser F, Westhoff T, Nunes de Miranda SM, Vehreschild MJGT, Lanznaster J, Dolff S, on behalf of the LEOSS study group. SARS-CoV-2 infection in chronic kidney disease patients with pre-existing dialysis: description across different pandemic intervals and effect on disease course (mortality). Infection 2022, 1-11. doi.org/10.1007/s15010-022-01826-7.

2021

Buchner B, Haber A, Hahn H, Kusch H, Prasser F, Sax U, Schmidt CO. Das Modell der Datentreuhand in der medizinischen Forschung. Datenschutz und Datensicherheit 45, 806–810 (2021). DOI: 10.1007/s11623-021-1534-y

Lawson J, Cabili MN, Giselle Kerry, Boughtwood T, Thorogood A, Alper P, Bowers SR, Boyles RR, Brookes AJ, Brush M, Burdett T, Clissold H, Donnelly S, Dyke SOM, Freeberg MA, Haendel MA, Hata C, Holub P, Jeanson F, Jene A, Kawashima M, Kawashima S, Konopko M, Kyomugisha I, Li H, Linden M, Rodriguez LL, Morita M, Mulder N, Muller J, Nagaie S, Nasir J, Ogishima S, Wang VO, Paglione LD, Pandya RN, Parkinson H, Philippakis AA, Prasser F, Rambla J, Reinold K, Rushton GA, Saltzman A, Saunders G, Sofia HJ, Spalding JD, Swertz MA, Tulchinsky I, van Enckevort EJ, Varma S, Voisin C, Yamamoto N, Yamasaki C, Zass L, Guidry Auvil JM, Nyrönen TH, Courtot M. The Data Use Ontology to streamline responsible access to human biomedical datasets. Cell Genomics 2021; 1(2):100028. DOI:10.1016/j.xgen.2021.100028

Pilgram L, Schons M, Jakob CEM, Claßen AY, Franke B, Tscharntke L, Schulze N, Fuhrmann S, Sauer G, Nunes de Miranda SM, Prasser F, Stecher M, Vehreschild JJ. Die COVID-19 Pandemie als Herausforderung und Chance für Register in der Versorgungsforschung: Erfahrungen aus Lean European Open Survey on SARS-CoV-2 Infected Patients (LEOSS). Gesundheitswesen 2021; 83(S 01): S45-S53. DOI: 10.1055/a-1655-8705.

Meurers T, Bild R, Do KM, Prasser F. A scalable software solution for anonymizing high-dimensional biomedical data. Gigascience 2021 Oct 4;10(10):giab068.

Wirth FN, Meurers T, Johns M, Prasser F. Privacy-preserving data sharing infrastructures for medical research: systematization and comparison. BMC Medical Informatics and Decision Making. (2021) 21:242.

Fluck J, Lindstädt B, Ahrens W, Beyan O, Buchner B, Darms J, Depping R, Dierkes J, Neuhausen H, Müller W, Zeeb H, Golebiewski M, Löffler M, Löbe M, Meineke F, Klammt S, Fröhlich H, Hahn H, Schulze M, Pischon T, Nöthlings U, Sax U, Kusch H, Grabenhenrich L, Schmidt CO, Waltemath D, Semler S, Gehrke J, Kirsten T, Praßer F, Thun S, Wieler L, Pigeot I. NFDI4Health – Nationale Forschungsdateninfrastruktur für personenbezogene Gesundheitsdaten. Bausteine Forschungsdatenmanagement. 2 (Juli 2021), 72–85. DOI: 10.17192/bfdm.2021.2.8331.

Stamm T, Bott N, Thwaites R, Mosor E, Andrews MR, Borgdorff J, Cossio-Gil Y, de Portu S, Ferrante M, Fischer F, Hameed F, Hazelzet J, Hopkins D, Kalra D, Metcalfe T, Molero E, Newson R, Patalano F, Prasser F, Rose M, Lindskov MS, Soderberg J, Strammiello V, van de Poll L, Styliadou M. Building a Value-Based Care Infrastructure in Europe: The Health Outcomes Observatory. NEJM Catalyst Innovations in Care Delivery. 2021 Jun 9;2(3).

Johns M, Müller A, Wirth FN, Prasser F. A Comprehensive Portal for Clinical and Translational Data Warehouses. Studies in Health Technology and Informatics 2021 May 27;281:462-466. doi: 10.3233/SHTI210201.

Pilgram L, Eberwein L, Wille K, Koehler FC, Stecher M, Rieg S, Kielstein JT, Jakob CEM, Rüthrich M, Burst V, Prasser F, Borgmann S, Müller RU, Lanznaster J, Isberner N, Tometten L, Dolff S & The LEOSS Study Group. Clinical course and predictive risk factors for fatal outcome of SARS-CoV-2 infection in patients with chronic kidney disease. Infection 2021 Apr 13;1-13. doi: 10.1007/s15010-021-01597-7.

Huber MK, Raichle C, Lingor P, Synofzik M, Borgmann S, Erber J, Tometten L, Rimili W, Dolff S, Wille K, Knauss S, Piepel C, Lanznaster J, Rieg S, Prasser F, Pilgram L, Spottke A, Klockgether T, Klein C, Hopfner F, Höglinger GU and the LEOSS Study Group (2021), Outcomes of SARS‐CoV‐2 Infections in Patients With Neurodegenerative Diseases in the LEOSS Cohort. Mov Disord.

2020

Jakob CEM, Kohlmayer F, Meurers T, Vehreschild JJ, Prasser F. Design and evaluation of a data anonymization pipeline to promote Open Science on COVID-19. Scientific Data Volume 7, Article Number: 435 (2020).

Wirth FN, Johns M, Meurers T, Prasser F. Citizen-Centered Mobile Health Apps Collecting Individual-Level Spatial Data for Infectious Disease Management: Scoping Review. JMIR Mhealth Uhealth 2020;8(11):e22594. doi: 10.2196/22594

Spengler, H, Gatz, I, Kohlmayer, F, Kuhn, K A, Prasser, F (2020, July). Improving Data Quality in Medical Research: A Monitoring Architecture for Clinical and Translational Data Warehouses. In 2020 IEEE 33rd International Symposium on Computer-Based Medical Systems (CBMS) (pp. 415-420). IEEE.

Wirth F, Johns M, Meurers T, Prasser F. Anonymisierung medizinischer Daten. digma - Zeitschrift für Datenrecht und Informationssicherheit. 20. Jahrgang, Heft 2, Juni 2020

Spengler H, Lang C, Mahapatra T, Gatz I, Kuhn KA, Prasser F. Enabling Agile Clinical and Translational Data Warehousing: Platform Development and Evaluation. JMIR Med Inform 2020;8(7):e15918

Raisaro JL, Marino F, Troncoso-Pastoriza J, Beau-Lejdstrom R, Bellazzi R, Murphy R, Bernstam EV, Wang H, Bucalo M, Chen Y, Gottlieb A, Harmanci A, Kim M, Kim Y, Klann J, Klersy C, Bradley A, Malin BA, Méan M, Prasser F, Scudeller L, Torkamani A, Vaucher J, Puppala M, Wong STC, Frenkel-Morgenstern M, Xu H, Maiyaki Musa B, Habib AG, Cohen T, Wilcox A, M Salihu HM, Sofia H, Jiang X, Hubaux JP. SCOR: A secure international informatics infrastructure to investigate COVID-19. Journal of the American Medical Informatics Association, ocaa172. Published: 10 July 2020

Bild R, Kuhn KA, Prasser F. Better Safe Than Sorry - Implementing Reliable Health Data Anonymization. Stud Health Technol Inform. 2020 Jun 16;270:68-72

Vogelsang L, Lehne M, Schoppmann P, Prasser F, Thun S, Scheuermann B, Schepers J. A Secure Multi-Party Computation Protocol for Time-To-Event Analyses. Stud Health Technol Inform . 2020 Jun 16;270:8-12

Bild R, Eicher J, Prasser F. Efficient Protection of Health Data From Sensitive Attribute Disclosure. Stud Health Technol Inform . 2020 Jun 16;270:193-197

Bild R, Bialke M, Buckow K, Ganslandt T, Ihrig K, Jahns R, Merzweiler A, Roschka S, Schreiweis B, Stäubert S, Zenker S, Prasser F. Towards a comprehensive and interoperable representation of consent-based data usage permissions in the German medical informatics initiative. BMC Medical Informatics and Decision Making. 20 (1), 1-9 (2020)

Eicher J, Bild R, Spengler H, Kuhn KA, Prasser F. A comprehensive tool for creating and evaluating privacy-preserving biomedical prediction models. BMC Medical Informatics and Decision Making. 20 (1), 1-14 (2020)

Prasser F, Eicher J, Spengler H, Bild R, Kuhn KA. Flexible data anonymization using ARX—Current status and challenges ahead. Software: Practice and Experience 2020. 50 (7), 1277-1304

Schaefer J, Lehne M, Schepers J, Prasser F, Thun S. The use of machine learning in rare diseases: a scoping review. Orphanet Journal of Rare Diseases Volume 15, Article number: 145 (2020)

2019