Cores Seminar Series – Emerging Trends in Systematic Reviews for 3R Principles
Course description
A systematic review uses a transparent and structured approach to identify and evaluate results of existing studies on a research question. Systematic reviews are a powerful tool to assess the accumulating evidence in biomedical research. As such, systematic reviews can help us address specific research questions and be used to directly inform the classical 3Rs principles in animal research – Replacement, Reduction, Refinement.
Systematic reviews themselves are considered animal-free innovations as they can lead to new results and scientific insights without performing additional animal studies. They can help prevent unnecessary duplication by comprehensively summarizing what has been done already as well as help us to choose the optimal animal model for our research questions. Systematic reviews can help us make evidence-informed decisions for animal research, including informing sample size calculations and refining experiments conduct, as well as supporting translational decisions. If you are interested to learn more about evidence synthesis, visit the COReS About Synthesis website section.
The conduct of systematic reviews to support animal research is increasing in popularity and advances and techniques are developing rapidly. This seminar series showcases emerging trends on systematic reviews of animal studies. During each session, an expert guest speaker will provide insights into their work in this space, showcasing specific tools, approaches and resources and sharing cutting edge ideas.
Seminar dates
October 8, 2024: GRADE for Animals – evaluating evidence to promote translation
Join our third seminar session with Dr. Carlijn Hooijmans to learn more about the GRADE approach for animals. What is it and how can we use this approach to evaluate research evidence to promote the translation of findings? Discover practical applications and latest developments.
Short biography:
Dr Carlijn Hooijmansis an Assistant Professor at the Department of Anesthesiology in the Meta-Research Team, at the Radboud University Medical Centre. In her research work, Carlijn focuseson evidence based preclinical medicine and improving the translation of findings from preclinical studies to clinical practice. She and colleaguesdescribed how the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach could be used to rate evidence of preclinical animal studies in the context of therapeutic interventions.Registration:
Please register here for the session.June 13, 2024: Systematic Online Living Evidence Summaries – using AI to accelerate in vivo synthesis
In the 2nd COReS seminar session, Dr Kaitlyn Hair will talk about SOLES – Systematic Online Living Evidence Summaries. What are Systematic Online Living Evidence Summaries? And how can we use this AI tool pipeline to accelerate the synthesis of in vivo research evidence?
Short biography:
Dr Kaitlyn Hair is a postdoctoral researcher in the CAMARADES group at the University of Edinburgh, where she is focusing on curating and evaluating evidence from preclinical animal models of neurological diseases. Kaitlyn has led the development of Systematic Online Living Evidence Summaries (SOLES) across different research domains. With her work, she aims to inform future research and improve methodological rigor and reporting quality.Registration:
Please register here for the session.March 28, 2024: Latest Developments on the Reporting Guideline PRISMA-Preclinical
In the 1st session, Dr Manoj M. Lalu will tell us more about PRISMA-Preclinical. Why do we need a PRISMA guideline specific for systematic reviews in animal research? How was it developed? And what will be the next steps?
Short biography:
Short Bio: Manoj M. Lalu, MD, PhD, FRCPC is an anesthesiologist and researcher focused on moving basic science discoveries to early phase clinical trials. He co-leads the Blueprint Translational Research Group at the Ottawa Hospital Research Institute. The group adopts a variety of approaches (systematic reviews/meta-research, qualitative interview studies, early economic analyses, preclinical lab studies) to better understand and improve the 'translational' process.Registration:
Please register here for the Session.