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BCRTGenetics/Genomics

Lymphovascular Medicine and Translational 3D-Histopathology

René Hägerling

At a Glance

The Research Group for Lymphovascular Medicine and Translational 3D-Histopathology develops innovative approaches for three-dimensional tissue analysis and precision diagnostics. Our work combines cutting-edge imaging technologies with advanced molecular methods, bridging the gap between basic research and clinical applications. Through the integration of 3D-histology, genomics, and AI-powered analysis, we are pioneering new paths in both rare disease research and precision oncology.

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Dr. Dr. Rene Hägerling

Contact information
Address:Universitätsmedizin Berlin Institut für Medizinische Genetik und Humangenetik Cranach Haus Augustenburger Platz 1 13353 Berlin

E-mail:rene.haegerling@charite.de

Research Focus

Focus Area 1: Advanced 3D-Histology and 3D-Spatial Biology

We develop and implement novel methods for three-dimensional tissue analysis, enabling unprecedented insights into tissue architecture and disease mechanisms through the integration of spatial information with multi-omics data.

Key Research Areas:

  • Development of tissue clearing and bleaching protocols
  • Light sheet microscopy-based optical sectioning
  • AI-powered 3D tissue analysis
  • Real-time organoid imaging
  • Spatial multi-omics integration
  • Deep tissue phenotyping

Technology Platforms:

  • Nanobody-based Tissue Staining Protocols
  • Light sheet microscopy
  • AI-based image analysis
  • High-throughput screening systems

Links

Focus Area 2: Precision Oncology and Integrative Diagnostics

We leverage our multi-modal diagnostic approach to advance cancer diagnosis and treatment, combining spatial information with molecular profiles.

Key Research Areas:

  • Multi-dimensional tumor analysis
  • Integration of genomics and 3D-histology
  • Development of novel diagnostic workflows
  • AI-driven pattern recognition
  • Liquid biopsy approaches
  • Patient Stratification

Focus Area 3: Next-Generation Nanobody Technology

Key Research Areas:

  • Novel Nanobody Screening Platform
  • Reversible, multiplex Stainings (>20 markers)
  • Diagnostic Imaging Tools
  • Targeted therapeutic approaches

Applications:

  • 3D-Histology and Molecular Imaging
  • Diagnostic Markers
  • Nanobodies for therapeutic interventions

Focus Area 4: Rare Vascular Disease / Vascular Anomalies / Primary Lymphedema

Our group specializes in the diagnosis and treatment of vascular anomalies, developing innovative approaches to improve patient care through comprehensive molecular and imaging diagnostics. We focus on translating research findings into targeted therapeutic strategies for these rare conditions.

Key Research Areas:

  • Genetic basis of vascular anomalies
  • Lymphatic malformation mechanisms
  • Gene therapy approaches
  • Biomarker development
  • Clinical phenotyping
  • Organoid and Mouse models
  • ICG Lymphography
  • Patient Stratification
  • Molecular Diagnostic test development
  • Liquid Biopsies
  • Whole Genome Sequencing

Our specialized clinics serve as central reference centers for patients with rare vascular diseases, providing comprehensive care through (Clinical Integration):

  • Expert consultation for complex cases
  • Advanced diagnostic services
  • Personalized therapy approaches
  • International patient registry
  • Multi-disciplinary treatment strategies

Technologies and Methods

Clinical Activities

Specialized Clinics

  • Primary Lymphedema Clinic
  • Vascular Anomalies and Segmental Overgrowth

Translation and Innovation

Funding

Major Grants

  • ERC Starting Grant PREVENT
  • ERC Proof-of-Concept 3D-SpatiOmics
  • Exist Forschungstransfer
  • Lymphatic Malformation Institute
  • Lipedema Foundation

Events

Summer School Lymphology

Annual international training program focusing on rare lymphatic vessel diseases, combining interdisciplinary approaches with modern teaching methods.

Team members

Publications

Open Positions

We are always looking for motivated scientists and students to join our interdisciplinary team. Our group offers excellent research opportunities in cutting-edge facilities, combining advanced imaging technologies with molecular biology and clinical research.

Current Opportunities

We welcome applications for:

  • MD thesis projects
  • Bachelor's and Master's theses
  • PhD positions
  • Postdoctoral positions

What We Offer:

  • State-of-the-art research environment
  • Interdisciplinary research projects
  • Clinical translation opportunities
  • International collaborations
  • Advanced technology platforms
  • Supportive team atmosphere

How to Apply? 

If you are interested in joining our team, please send your application including:

  • CV
  • Brief statement of research interests
  • Academic transcripts

Contact information for references to: rene.haegerling@charite.de

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