Publications

Selected Publications

Below you can find a selection of BCRT publications from the past five years.

• Lung tumouroids as a testing platform for precision CAR T cell therapy
  Ehlen L et al. Nature Biomedical Engineering, 2026, DOI:10.1038/s41551-025-01594-3

• Cell type-specific response to curvature controls tissue growth dynamics in biomaterial pores
  Herrera A et al. Bioact Mater. 2026, doi: 10.1016/j.bioactmat

• Gravity-Tolerant In-Flight 3D Bioprinting Enabled by Stereolithography for Space Tissue Engineering
  Lemke B et al. Adv Sci (Weinh), 2026, DOI:10.1002/advs.202520715

• The cortical microenvironment drives early immune organization and controls early osteoclastogenesis in bone healing
  Noom A et al. Nature Communications, 2026, DOI:10.1038/s41467-026-77196-7

• A 3D Human Bone and Bone Marrow-on-a-Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance.
  Stelzer N et al. Adv Sci (Weinh). 2026, DOI: 10.1002/advs.202518224

• ILOBONE: A phase I/IIa randomized controlled trial to assess the safety and feasibility of local iloprost therapy for enhancing proximal humerus fracture healing- a pilot study design
  Elazaly H et al. Orthop Surg Res. 2025, DOI: 10.1186/s13018-025-05865-2.

• Generation of Regulatory T Cells From Human Memory CD4+ T Cells by Upregulation of Naked Cuticle Homolog 
  He J et al. European Journal of Immunology, 2025, DOI:10.1002/eji.70018

• Water and ions binding to extracellular matrix drives stress relaxation, aiding MRI detection of swelling-associated pathology
  Kollert MR et al. Nat Biomed Eng, 2025, DOI: 10.1038/s41551-025-01369-w

• Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors
  Launspach M et al. Nature Communications, 2025, DOI:10.1038/s41467-025-67328-w

• HLA matching or CRISPR editing of HLA class I/II enables engraftment and effective function of allogeneic human regulatory T cell therapy in a humanized mouse transplantation model
  McCallion O. et al. Nature Communications, 2025, DOI:10.1038/s41467-025-64945-3

• State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases
  Van Linthout S et al. European Journal of Heart Failure, 2025, DOI:10.1002/ejhf.3516

• Targeting TGF-β signaling, oxidative stress, and cellular senescence rescues osteoporosis in gerodermia osteodysplastica
  Chan WL et al. Aging Cell, 2024, DOI:10.1111/acel.14322

• The rise of patient avatars in precision oncology
  Ehlen L and Schmueck-Henneresse, M Nature Biotechnology, 2024, DOI: 10.1038/s41587-024-02335-8

• Acquisition of epithelial plasticity in human chronic liver disease
  Gribben C et al. Nature. 2024 doi: 10.1038/s41586-024-07465-2.

• FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
  Brevini T et al. Nature, 2023 DOI: 10.1038/s41586-022-05594-0.

• The enhancer landscape predetermines the skeletal regeneration capacity of stromal cells 
  Hochmann S et al. Science Translational Medicine, 2023, DOI:10.1126/scitranslmed.abm7477

• Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors
  Kotsaris G et al. Regenerative Medicine, 2023, DOI:10.1038/s41536-023-00291-6

• A comprehensive molecular profiling approach reveals metabolic alterations that steer bone tissue regeneration
  Löffler J et al. Communications Biology, 2023, DOI:10.1038/s42003-023-04652-1

• Preparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion
  Amini L et al. Nature Reviews Clinical Oncology, 2022, DOI:10.1038/s41571-022-00607-3

• Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells
  Kath J et al. Molecular Therapy – Methods & Clinical Development, 2022, DOI:10.1016/j.omtm.2022.03.018

• Adoptive transfer of ex vivo expanded regulatory T cells improves immune cell engraftment and therapy-refractory chronic GvHD
  Landwehr-Kenzel S et al. Molecular Therapy, 2022, DOI:10.1016/j.ymthe.2022.02.025

• Bio-instructive hydrogel expands the paracrine potency of mesenchymal stem cells
  Drzeniek NM et al. Biofabrication, 2021, DOI:10.1088/1758-5090/ac0a32

Paper of the Month Award for the BCRT Community

The Paper of the Month series was run by the BIH until 2022.