Our DFG-Emmy Noether Program-funded lab has two main focuses: First, we are developing in vivo tissue regeneration as a therapeutic strategy. Second, we aim to understand the dynamics between hematopoietic and hepatic systems in development and disease using blood-liver organoids.
The research group Model Systems for Regenerative Therapies leverages interdisciplinary approaches to interdisciplinary and translational research. Our goal is to improve our mechanistic pathophysiological understanding regarding musculoskeletal fibrosis to a level where we can offer effective solutions for clinical applications.
Through the development and implementation of science-based tools and policies, the group contributes to the alignment of internal administration and governance processes of incentives and research assessments with responsible research and innovation (RRI) as well as open sciences practices. The goal is to transfer best practice and knowledge into…
Infectious diseases remain one of the major causes of death world-wide. Emerging infections, such as the COVID-19 pandemic or the MPVX outbreak, but also the dramatic increase in antibiotic resistance illustrate the urgent need for novel antimicrobial interventions. Vaccines represent one of the most powerfull, safe and cost-effective tools to…
Additive manufacturing (AM) technologies could be the leverage for the generation of precise and personalized scaffold constructs enabling improved bone regeneration and remodeling outcomes. Our team strives to develop methodologies and generate knowledge that could lead to mechanistic understanding of scaffold-guided bone defect regeneration…
The objective of our research group is to acquire the basic knowledge necessary to develop new therapies against diseases affecting the liver. For that, we use stem cells to model embryonic development in vitro and to produce liver cells with an interest for cell therapy.
Systematic review and meta-analysis are research synthesis methods that clearly identify what we currently know, how reliable the evidence is, and where future research is needed. Using these tools, the “Preclinical systematic reviews and meta analyses” group aims to improve the validity, increase the value, and facilitate the translation of…
Tissues in the musculoskeletal system are exquisitely designed with superb mechanical properties. The tissues are also able to adapt to withstand changing mechanical conditions. The Computational Mechanobiology Group is focused on understanding these two exciting features. Using computer modeling techniques, we seek to understand the mechanical…
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The group „Systemic Perspectives in Translational Biomedicine” investigates research processes in (preclinical) biomedical research. The path from an initial discovery to the patient is long and challenging. One important building block of successful translation is the generation of robust evidence. At BIH and beyond, we explore how such evidence…