Genome instability and somatic mosaicism
Ashley Sanders
We sequence cells to understand how genetic mutations form and change cell states in health and disease.
We sequence cells to understand how genetic mutations form and change cell states in health and disease.
Our research focuses on molecular changes in the development of various tumors. We now want to use bioinformatic and experimental methods to better understand the early development of cancer in order to be able to intervene and prevent it in the long term.
Our motivation is to address fundamental biological questions of human immunology and translate them into innovative therapies. In this respect, the core interest of our laboratory lies in the discovery of new applications of antibodies and B cells to treat and prevent challenging human diseases.
The Medical Omics lab aims to improve healthcare and basic research by providing artificial intelligence-driven tools for the analysis of large biomedical datasets. For comprehensive insights in disease entities, we aim to include multiple layers of data, such as single-cell RNA sequencing, methylomics data and medical imaging. In close…
Rapid advances in molecular biology technologies are leading to a data explosion in biomedical research and clinical diagnostics. The goal of our department is to develop new and targeted ways to analyze and evaluate these data sets in order to implement innovations that benefit patients. For instance, it is desirable to make information from…
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The main research area of the Bioinformatics and Translational Genetics group is the elucidation of single gene disorders (diseases caused by DNA mutations in a single gene). We are developing user-friendly software that can be used by non-IT specialists. This allows the physicians – who know most about the patients and their disorders – to analyse…
Hypertension affects more than one billion people worldwide. As the leading risk factor for global disease burden, it contributes to more than nine million deaths annually. The mission of the Scholl group is the discovery and characterization of novel mechanisms underlying human disease. We focus on genetic causes of childhood hypertension and…
Since 2017, Martin Kircher heads the "Computational Genome Biology" working group at BIH. With the appointment as professor for regulatory genomics at the University of Lübeck and the University Hospital Schleswig-Holstein in 2022, Prof. Kircher continued his research as a BIH Fellow at the two locations. At the Berlin site, the research group is…
Our research focuses on genetics, gene therapy, immunology and cancer.