We sequence cells to understand how genetic mutations form and change cell states in health and disease.

The Gütig lab uses analytical and numerical modeling techniques to identify the computational principles underlying spike based information processing and learning in central nervous systems and to understand how these principles are implemented by biological processes. Specifically, the lab focuses on the role of action potential timing in sensory…

Our research focuses on molecular changes in the development of various tumors. We now want to use bioinformatic and experimental methods to better understand the early development of cancer in order to be able to intervene and prevent it in the long term.

Our motivation is to address fundamental biological questions of human immunology and translate them into innovative therapies. In this respect, the core interest of our laboratory lies in the discovery of new applications of antibodies and B cells to treat and prevent challenging human diseases.

The Medical Omics lab aims to improve healthcare and basic research by providing artificial intelligence-driven tools for the analysis of large biomedical datasets. For comprehensive insights in disease entities, we aim to include multiple layers of data, such as single-cell RNA sequencing, methylomics data and medical imaging. In close…

Rapid advances in molecular biology technologies are leading to a data explosion in biomedical research and clinical diagnostics. The goal of our department is to develop new and targeted ways to analyze and evaluate these data sets in order to implement innovations that benefit patients. For instance, it is desirable to make information from…

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Common metabolic disorders such as obesity, insulin resistance and type 2 diabetes have both environmental and genetic causes. We now know that many sections of the genome influence the risk of weight gain or adverse fat distribution, in addition to the important roles played by lack of physical activity and excessive intake of high-calorie foods.…

The main research area of the Bioinformatics and Translational Genetics group is the elucidation of single gene disorders (diseases caused by DNA mutations in a single gene). We are developing user-friendly software that can be used by non-IT specialists. This allows the physicians – who know most about the patients and their disorders – to analyse…