The objective of our research group is to acquire the basic knowledge necessary to develop new therapies against diseases affecting the liver. For that, we use stem cells to model embryonic development in vitro and to produce liver cells with an interest for cell therapy.

We sequence cells to understand how genetic mutations form and change cell states in health and disease.

Bone is an interesting tissue from the researchers view as it is able to regenerate after injury. However, even today and with an adequate treatment 5-20% of all fractured patients experience a delayed or non-union.

Tissues in the musculoskeletal system are exquisitely designed with superb mechanical properties. The tissues are also able to adapt to withstand changing mechanical conditions. The Computational Mechanobiology Group is focused on understanding these two exciting features. Using computer modeling techniques, we seek to understand the mechanical…

Our motivation is to address fundamental biological questions of human immunology and translate them into innovative therapies. In this respect, the core interest of our laboratory lies in the discovery of new applications of antibodies and B cells to treat and prevent challenging human diseases.

The Medical Omics lab aims to improve healthcare and basic research by providing artificial intelligence-driven tools for the analysis of large biomedical datasets. For comprehensive insights in disease entities, we aim to include multiple layers of data, such as single-cell RNA sequencing, methylomics data and medical imaging. In close…

Rapid advances in molecular biology technologies are leading to a data explosion in biomedical research and clinical diagnostics. The goal of our department is to develop new and targeted ways to analyze and evaluate these data sets in order to implement innovations that benefit patients. For instance, it is desirable to make information from…

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The Sawitzki lab investigates the molecular mechanisms of immune cell activation and tolerance induction, in order to better understand why components of the immune response themselves become a trigger of destructive inflammatory reactions, like e.g. in the context of autoimmune diseases, rejection reactions after organ transplantation or COVID19…

Not only the DNA sequence – our genome – but also the 3D structure of our genome – the 'epi-genome' – is essential in determining the type and function of a cell. That's why the analysis of the epigenome facilitates deep insights into the developmental history of a cell and its current gene expression profile, but also allows deductions on its…