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6R: 3R (Replace, Reduce, Refine) + Robustness, Registration, Reporting in Organ Model Research

Advanced in vitro models have strong potential to complement or substitute animal experiments and improve translational research. We collaborate with organ model researchers to develop and implement measures towards robust organ models and enhance their broad acceptance via 6R strategies.

Background / Rationale

Human organ models (organoids, multiphysiological systems, chips, explants, etc.) open up unique opportunities for the study of human diseases and the targeted treatment design. There is growing evidence that 3D organ models can better reflect human biology than traditional 2D cell cultures and many animal models.

However, crucial for the broad acceptance and successful application of these alternative methods in translational biomedical research is the demonstration of their reliability and robustness. Our team at the QUEST Center is working on the following two 6R projects with organ model researchers in Germany:

6R cross-sectional Projekt im Einstein Center 3R Berlin

Systematic Reviews for in vitro organ models

Funder and Cooperation Partner

[Translate to englisch:]

Dr. Maren Hülsemann

Research fellow - Einstein Center 3R

Contact information
Phone:+49 30 450 543 667