CAMARADES (Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies) Berlin applies and supports systematic review and meta-analysis of preclinical studies to investigate challenges in the translation of biomedical research.
These meta-research tools provide a summary of research findings and allow evaluation of both the range and quality of evidence addressing specific research questions. The results can help inform decision-making and the development of improvement strategies for preclinical research and translation.
Our Facility for the Systematic Review and Meta-analysis of Animal Studies provides Charité and BIH researchers with education and training on systematic review of animal studies, and methodological support to perform robust, high-quality reviews.
Additionally, we review published Charité and BIH animal studies to benchmark quality and 3Rs (Replacement, Reduction, and Refinement) criteria, identify opportunities for improvement strategies, and monitor their impact over time. We aim to support higher quality, more ethical animal research, which is more likely to translate to benefit in human patients.