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The PREMIER project, funded by the Volkswagen Foundation, aims to develop a structured quality assurance system for preclinical academic biomedicine. From 2014-2017, we were probably the only academic research institution worldwide to maintain a certified quality management system according to DIN EN ISO 9001:2008. Our familiarity with the advantages and disadvantages of a highly structured but general quality management system and as a response to the existing replication crisis has led us to develop a QM system (PREMIER) that is tailored to academic research.

With PREMIER we propose to improve the quality of academic preclinical biomedicine through structured quality assurance measures. Existing approaches, norms and systems are resource-intensive and hardly suitable for preclinical biomedical research, especially in academia where additional regulatory elements are viewed as a threat to creativity, and therefore widely scorned by scientists. We have now developed a quality assurance system tailored to academic biomedicine consisting of "building blocks" of quality assurance measures that are modular, scalable, practical, affordable and acceptable to science.

Since it must be possible to monitor compliance with the standards, we have developed a new approach for verifying compliance with defined quality standards. New practicable options for auditing, such as "peer auditing", make it possible to assess compliance with standards. They also have the potential to improve the quality of preclinical research in the scientific community and support the daily work routine in the laboratory. PLOS ONE

Standards will be established in exchange of ideas with national and international scientists as well as with scientific organisations and sponsors, and complemented by meta-search.

PREMIER now offers scientists and research administrators the opportunity to pursue a more systematic and comprehensive approach to improving research quality in a modular way and with a low implementation threshold.
In addition to providing freely available tools, such as an anonymous error reporting system (LabCIRS), a research wiki and various templates (e.g. for SOPs, experimental design, etc.), we also support researchers with the consulting services of Responsible PrecliniX (RPX). RPX accompanies projects from the research question to publication and clinical implementation and offers a wide range of services within the research process.

Detailed information can be found on the PREMIER website.

PREMIER symposium report

QM House

The PREMIER model is a conceptual framework of modules with minimum requirements, which can adapt to the needs and resources of any organisation. PREMIER will use quality assurance and control of processes as well as tools to achieve and support reproducibility of the experimental results.


Advisory board

The PREMIER advisory board will lend us scientific support and external expertise for our purpose. They will give us advice and help us in all scientific issues during the project.

Six members who are experts in the fields of open science / open data and scientific research, as well as a scientific publisher, scientific sponsor and a member of the Volkswagenstiftung are part of the advisory board.

Members of the PREMIER advisory board:

  • Dr. Oliver Grewe

    Scientific Consultant Life Sciences

    Contact information
    Phone:+49 511 8381-252
  • Prof. Dr. Anton Bespalov

    CEO, Partnership for Assessment and Accreditation of Scientific Practice GmbH

    Contact information
  • Prof. Dr. Michael Gotthardt

    Professor for Experimental and Translational Cardiology

    Contact information
  • Dr. Katja Hartig

    Program Director Life Sciences

    Contact information
    Phone:+49 228 885-2359
  • Dr. Bernd Pulverer

    Chief Editor and Head of Scientific Publications

    Contact information
  • Dr. Paul Schultze-Motel

    Coordinator - Helmholtz Open Science

    Contact information
    Phone:+49 331 288-1653

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Dipl. Biochem. Claudia Kurreck

Quality manager | Research fellow

Contact information
Phone:+49 30 450 560 664