Talk@BCRT | Nan Ma (Helmholtz Center Hereon)
Vortrag zum Thema: "Precision Regeneration: Leveraging Physical Cues and Biomaterials To Control Stem Cell Fate" gefolgt von einer Meet-the-Speaker-Session. >> Bei Interesse an einem 1:1 Meeting mit Nan Ma kontaktieren Sie bitte: [email protected]
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Talk
“Precision Regeneration: Leveraging Physical Cues and Biomaterials To Control Stem Cell Fate”
Physical factors from the natural habitat are crucial regulators of stem cell development. Our research investigates how various aspects of the microenvironment—such as curvature, mechanical stretching, surface patterning, ligand density, and thermal cues—critically influence stem cell behavior. Curvature affects cellular adhesive junctions and the reversion to a naive state by mimicking the natural topography of blastocyst. Mechanical stretching simulates physiological strain, impacting morphogenesis and cellular alignment. Thermal signals, delivered via shape memory materials, regulate calcium influx, metabolic activity, and differentiation processes. Additionally, the density of adhesive ligands in the extracellular matrix modulates cell attachment and subsequent signaling pathways, affecting cell fate and organoid formation. We also explore how modulating the porosity of electrospun cardiac patches can influence anti-inflammatory macrophage infiltration and cell responses, potentially optimizing the inflammatory environment for cardiac tissue regeneration. By elucidating these interactions, we aim to integrate physical cues into biomaterial design to precisely control stem cell fate, enhancing tissue regeneration and advancing regenerative medicine.
About the Speaker
Nan Ma (Helmholtz Center Hereon)
Prof. Nan Ma obtained a MS degree in Immunology from Institute of Hematology, Chinese Academy of Medical Sciences/Peking Union Medical College in 1998, and PhD degree in Biomedical Engineering from Institute of Materials Research and Engineering, National University of Singapore, in 2003.
She is currently head of department “Sustainable Biomaterials” at the Helmholtz Center Hereon in Teltow and Professor in the Department of Biochemistry at Freie Universität Berlin. Her research interests include physical factors of biomaterial and their influence on stem cells, nanocarrier systems and tissue regeneration applications.
Selected publications and patents
Selected publications and patents
- Xu, X., et al. (Accepted). Design Criteria for Geometrical Cues Reverting Pluripotent Stem Cell State to Naivety. Nature Materials.
- Bhaskar, T., et al. (2023). Laminin–Dynamic Bonds Enable Multifunctionality in a Biological 2D Network. Advanced Functional Materials, 33(46).
- Wing, T., et al. (2022). In Vivo Performance of a Cell and Factor Free Multifunctional Fiber Mesh Modulating Postinfarct Myocardial Remodeling. Advanced Functional Materials, 32(31), 2110179.
- Vogt, A., et al. (2016). Nanocarriers for Drug Delivery into and through the Skin - Do Existing Technologies Match Clinical Challenges? Journal of Controlled Release, 242, 3-15.
- US7205387B2, WO2005021758A1: Recombinant polypeptide useful for neurotrophin receptor-mediated gene delivery and as a neurotrophin agonist, Shu Wang, Shan Shan, Assignee: Agency for Science Technology and Research, Singapore. Wu Shan Shan, Jieming Zeng, Nan Ma, adjusted expiration 2024-05-05, Assignee: Agency for Science Technology and Research, Singapore
- EP 24160389.3: Substrates mimicking the blastocyst geometry revert pluripotent stem cell to naivety, 2024, Nan Ma, Weiwei Wang, Xun Xu, Assignee: Helmholtz Center HEREON.
Info
When:
September 12, 2024
Talk: 12:30 - 01:30 pm
1:1 Meeting: 01:30 - 05:00 pm
Where:
BIH Center for Regenerative Therapies (BCRT)
Cranach Haus, Auditorium
Föhrer Str. 15, 13353 Berlin
Registration:
Please contact: contact@b-crt.de
