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Talk

“Precision Regeneration: Leveraging Physical Cues and Biomaterials To Control Stem Cell Fate”
 

Physical factors from the natural habitat are crucial regulators of stem cell development. Our research investigates how various aspects of the microenvironment—such as curvature, mechanical stretching, surface patterning, ligand density, and thermal cues—critically influence stem cell behavior. Curvature affects cellular adhesive junctions and the reversion to a naive state by mimicking the natural topography of blastocyst. Mechanical stretching simulates physiological strain, impacting morphogenesis and cellular alignment. Thermal signals, delivered via shape memory materials, regulate calcium influx, metabolic activity, and differentiation processes. Additionally, the density of adhesive ligands in the extracellular matrix modulates cell attachment and subsequent signaling pathways, affecting cell fate and organoid formation. We also explore how modulating the porosity of electrospun cardiac patches can influence anti-inflammatory macrophage infiltration and cell responses, potentially optimizing the inflammatory environment for cardiac tissue regeneration. By elucidating these interactions, we aim to integrate physical cues into biomaterial design to precisely control stem cell fate, enhancing tissue regeneration and advancing regenerative medicine.

Selected publications and patents

Info

When:
September 12, 2024 
Talk: 12:30 - 01:30 pm
1:1 Meeting: 01:30 - 05:00 pm

Where:
BIH Center for Regenerative Therapies (BCRT)
Cranach Haus, Auditorium
Föhrer Str. 15, 13353 Berlin

Registration:
Please contact: contact@b-crt.de

kontakt

Kristina Helen Dewsbery

Office-Management

Kontaktinformationen
Telefon:+49 (0)30 450 539 464
E-Mail:kristina.dewsbery@charite.de