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Cardiology Science Lunch Berlin

Rudolf Zechner:
“Physiology and Pathophysiology of Fat Lipolysis”

(Institute of Molecular Biosciences, Medical University of Graz, Austria &
Einstein BIH Visiting Fellow, Berlin, Germany)

Ulrich Kintscher

Charité - Universitätsmedizin Berlin
Director of the Institute of Pharmacology
Center for Cardiovascular Research




About the Speaker

Rudolf Zechner studies the mechanisms regulating lipid metabolism and causes of metabolic
diseases. His team specifically focuses on fat-degrading enzymes called lipases. Discovery of
adipose triglyceride lipase and the demonstration that this enzyme initiates fat catabolism in
mice and humans overturned our understanding of the lipolytic pathway. More recently,
Zechner's laboratory investigates how the breakdown of fat affects cellular signaling processes
and cell function. Discoveries of the Zechner laboratory identified crucial links between fat
catabolism, nuclear receptor signaling and heart function or the role of lipolysis in
thermogenesis. Current work focuses on the functional impact of lipolysis in the pathogenesis
of cancer-associated cachexia, a fatal wasting disease that is characterized by the unintended
loss of body weight. Furthermore, the finding that pharmacological inhibition of adipose
triglyceride lipase reduces high fat diet-induced obesity, glucose intolerance, and liver steatosis
in mice, drives current efforts to probe the enzyme's potential as a therapeutic target to treat
obesity-related metabolic disorders.

Source: US National Academy of Sciences, Member Directory

BIH Einstein Visiting Fellowship

BIH Einstein Visiting Fellowship

Rudolf Zechner has been an Einstein BIH Visiting Fellow since 2019 hosted by the research project "Adipose triglyceride lipase in chronic heart failure (Atgl-CHF)" of Prof. Dr. Ulrich Kintscher (Charité).

Einstein BIH Visiting Fellows are top-level scientists working abroad and recruited for continuous activities as visiting scientists at the BIH and its partners, the Charité and MDC. They are leading researchers in their field of the life sciences. The fellowships are not conceived for the classic visiting professors coming for an uninterrupted guest stay of one to two semesters (based frequently on taking leave) but for scientists remaining employed by and active at their home institution abroad while simultaneously contributing to the life sciences in Berlin on an ongoing basis.

Einstein Foundation

Further information




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Organized by

Charité – Universitätsmedizin Berlin
Klinik für Innere Medizin m.S. Kardiologie
Deutsches Herzzentrum Berlin
Klinik für Innere Medizin ─ Kardiologie


November 23, 2022
12-1 pm

Charité - Universitätsmedizin Berlin
Campus Virchow-Klinikum
Hörsaal 6 (main lecture hall), Mittelallee 10
Augustenburger Platz 1, 13353 Berlin

via email to: info@sciencelunch.de