• Center of Digital Health

Digital Health

Roland Eils

Roland Eils' department at BIH consists of four working groups: Artificial Intelligence (Roland Eils), Computational Oncology (Naveed Ishaque), Health Data (Harald Wagener, Sven Twardziok, Dirk Meyer zum Büschenfelde) and Medical Omics (Sören Lukassen). The department is part of the BIH Center of Digital Health; Roland Eils is the chair and founding director of this center.

Prof. Dr. Roland Eils

Gründungsdirektor des BIH-Zentrums Digitale Gesundheit

Phone:
+49 30 450 543 084
E-mail:
roland.eils[at]bih-charite.de
Address:
Luisenstr. 65
10117 Berlin

Roland Eils is also heading the Hub for Innovations in Digital Health, HiDiH, a joint collaboration of his BIH unit and the Health Data Science Unit at the Medical Faculty of Heidelberg University. In addition, Roland Eils is an active member of the Medical Informatics Initiative, where he has founded and coordinated HiGHmed. HiGHmed brings together 10 university medical centers for developing interoperable solutions and infrastructures for processing and sharing of clinical and translational research data.

Artificial Intelligence - ailslab

Roland Eils has assembled a small but highly innovative team of students and scientists venturing into different aspects of digital health. The ailslab focusses on innovative methods from the wider field of artificial intelligence for pioneering digital health applications. At the heart of this lab is the integration of huge and deep datasets from both healthcare and research for tackling pressing issues in health and disease. The ambition is to deepen our understanding of disease mechanisms and to improve diagnosis and treatment of cardiovascular and cancer patients among others. Current projects focus on cardiovascular risk modelling, omni-genetic phenotype models, and building computational frameworks with model-to-data approaches for opening medical data for research purposes. Please visit https://www.hidih.org/research/ailslab for further details. 

Selected Publications

  • Selected Publications Roland Eils, Artificial Intelligence

    - Hegselmann S., von Arnim G., Rheude T., et. al. (2025). Large Language Models are Powerful Electronic Health Record Encoders. arXiv:2502.17403. https://doi.org/10.48550/arXiv.2502.17403

    - Rheude T., Eils R., Wild B. (2026). Fusion or Confusion? Multimodal Complexity Is Not All You Need. arXiv:2512.22991. https://doi.org/10.48550/arXiv.2512.22991

    - Steinfeldt J., Wild B., Buergel T. et al. Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats. (2025) Nat Commun 16, 585. https://doi.org/10.1038/s41467-025-55879-x

    - Sandmann S., Hegselmann S., Fujarski M. et al. Benchmark evaluation of DeepSeek large language models in clinical decision-making. (2025). Nat Med 31, 2546–2549. https://doi.org/10.1038/s41591-025-03727-2

    - Duan Q., Huang B., Song Z. et.al. JanusDNA: A Powerful Bi-directional Hybrid DNA Foundation Mode (2025). https://neurips.cc/virtual/2025/loc/san-diego/poster/119543

    - Trump, S.*, Lukassen, S.*, Anker, M.S.*, Chua, R.L.*, Liebig, J.*, Thurmann, L.*, Corman, V.M.*, Binder, M.*, Loske, J., Klasa, C., Krieger, T., Hennig, B.P., Messingschlager, M., Pott, F., Kazmierski, J., Twardziok, S., Albrecht, J.P., Eils, J., Hadzibegovic, S., Lena, A., Heidecker, B., Burgel, T., Steinfeldt, J., Goffinet, C., Kurth, F., Witzenrath, M., Volker, M.T., Muller, S.D., Liebert, U.G., Ishaque, N., Kaderali, L., Sander, L.E., Drosten, C., Laudi, S.§, Eils, R.§, Conrad, C.§, Landmesser, U.§, & Lehmann, I.§ (2020). Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19. Nature Biotechnology doi: 10.1038/s41587-020-00796-1

    - Chua, R.L.*, Lukassen, S.*,Trump, S.*, Hennig, B.P.*, Wendisch, D.*, Pott, F., Debnath, O., Thürmann, L., Kurth, F., Völker, M.T., Kazmierski, J., Timmermann, B., Twardziok, S., Schneider, S., Machleidt, F., Müller-Redetzky, H., Maier, M., Krannich, A., Schmidt, S., Balzer, F., Liebig, J., Loske, J., Suttorp, N., Eils, J., Ishaque, N., Liebert, U.G., von Kalle, C., Hocke, A., Witzenrath, M., Goffinet, C., Drosten, C., Laudi, S.§,Lehmann, I., Conrad, C.§, Sander, L.-E.§ & Eils, R.§ (2020). COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis. Nature Biotechnology doi: 10.1038/s41587-020-0602-4

    - Lukassen, S.*, Chua, R. L.*, Trefzer, T.*, Kahn, N.C.*, Schneider, M.A.*, Muley, T., Winter, H., Meister, M., Veith, C., Boots, A.W., Hennig, B.P., Kreuter, M.§, Conrad, C.§, & Eils, R.§ (2020). SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. EMBO Journal, 39(10), doi: 10.15252/embj.20105114

    - Upmeier zu Belzen, J., Bürgel, T., Holderbach, S., Bubeck, F., Adam, L., Gandor, C., Klein, M., Mathony, J., Pfuderer, P. L., Platz, L., Przybilla, M., Schwendemann, M., Heid, D., Hoffmann, M. D., Jendrusch, M., Schmelas, C., Waldhauer, M., Lehmann, I., Niopek, D.§ & Eils, R.§ (2019). Leveraging implicit knowledge in neural networks for functional dissection and engineering of proteins. Nature Machine Intelligence 1, 225-235. doi: 10.1038/s42256-019-0049-9

    - Zapatka, M.*, Borozan, I.*, Brewer, D.S.*, Iskar, M.*, Grundhoff, A., Alawi, M., Desai, N., Cooper, C.S., Eils, R., Ferretti, V. & Lichter, P.§ (2020). The landscape of viral association in human cancers. Nature Genetics, doi: 10.1101/465757

    - Liu, L.*, Liu, C.*, Quintero, A.*, Wu, L*., Yuan, Y.*, Wang, M., Cheng, M., Leng, L., Xu, L., Dong, G., Li, R., Liu, Y., Wei, X., Xu, J., Chen, X., Lu, H., Chen, D., Wang, Q., Zhou, Q., Lin, X., Li, G., Liu, S., Wang, Q., Wang, H., Fink, J.L., Gao, Z., Liu, X., Hou, Y., Zhu, S., Yang, H., Ye, Y., Lin, G., Chen, F., Herrmann, C., Eils, R.§, Shang, Z.§ & Xu, X.§ (2019). Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity. Nature Communications, 10(1), 470. doi: 10.1038/s41467-018-08205-7

    - Northcott, P. A.*, Buchhalter, I.*, Morrissy, A. S.*, Hovestadt, V., Weischenfeldt, J., Ehrenberger, T., Gröbner, S., Segura-Wang, M., Zichner, T., Rudneva, V. A., Warnatz, H. J., Sidiropoulos, N., Phillips, A. H., Schumacher, S., Kleinheinz, K., Waszak, S. M., Erkek, S., Jones, D. T. W., Worst, B. C., Kool, M., Zapatka, M., Jäger, N., Chavez, L., Hutter, B., Bieg, M., Paramasivam, N., Heinold, M., Gu, Z., Ishaque, N., Jäger-Schmidt, C., Imbusch, C. D., Jugold, A., Hübschmann, D., Risch, T., Amstislavskiy, V., Gonzalez, F. G. R., Weber, U. D., Wolf, S., Robinson, G. W., Zhou, X., Wu, G., Finkelstein, D., Liu, Y., Cavalli, F. M. G., Luu, B., Ramaswamy, V., Wu, X., Koster, J., Ryzhova, M., Cho, Y. J., Pomeroy, S. L., Herold-Mende, C., Schuhmann, M., Ebinger, M.,   Liau, L. M., Mora, J., McLendon, R. E., Jabado, N., Kumabe, T., Chuah, E., Ma, Y., Moore, R. A., Mungall, A. J., Mungall, K. L., Thiessen, N., Tse, K., Wong, T., Jones, S. J. M., Witt, O., Milde, T., Von Deimling, A., Capper, D., Korshunov, A., Yaspo, M. L., Kriwacki, R., Gajjar, A., Zhang, J., Beroukhim, R., Fraenkel, E., Korbel, J. O., Brors, B., Schlesner, M., Eils, R.§, Marra, M. A.§, Pfister, S. M.§, Taylor, M. D.§ & Lichter, P.§ (2017). The whole-genome landscape of medulloblastoma subtypes. Nature. 2017 Jul 19;547(7663):311-317. doi: 10.1038/nature22973

    - Bauer, T.*, Trump, S.*, Ishaque, N.*, Thurmann, L.*, Gu, L.*, Bauer, M.*, Bieg, M., Gu, Z.G., Weichenhan, D., Mallm, J.P., Roder, S., Herberth, G., Takada, E., Mucke, O., Winter, M., Junge, K.M., Grutzmann, K., Rolle-Kampczyk, U., Wang, Q., Lawerenz, C., Borte, M., Polte, T., Schlesner, M., Schanne, M., Wiemann, S., Georg, C., Stunnenberg, H.G., Plass, C., Rippe, K., Mizuguchi, J., Herrmann, C.*, Eils, R.§ & Lehmann, I.§ (2016). Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children. Molecular Systems Biology, 12(3). doi: 10.15252/msb.20156520

    - Jäger, N., Schlesner, M., Jones, David T.W., Raffel, S., Mallm, J.-P., Junge, Kristin M., Weichenhan, D., Bauer, T., Ishaque, N., Kool, M., Northcott, Paul A., Korshunov, A., Drews, Ruben M., Koster, J., Versteeg, R., Richter, J., Hummel, M., Mack, Stephen C., Taylor, Michael D., Witt, H., Swartman, B., Schulte-Bockholt, D., Sultan, M., Yaspo, M.-L., Lehrach, H., Hutter, B., Brors, B., Wolf, S., Plass, C., Siebert, R., Trumpp, A., Rippe, K., Lehmann, I., Lichter, P., Pfister, Stefan M. & Eils, R.§ (2013). Hypermutation of the Inactive X Chromosome Is a Frequent Event in Cancer. Cell, 155(3), 567-581. doi: 10.1016/j.cell.2013.09.042

    - Kohler, S., Boscá, D., Kärcher, F., Haarbrandt, B., Prinz, M., Marschollek, M., & Eils, R. (2023). Eos and OMOCL: Towards a seamless integration of openEHR records into the OMOP Common Data Model. Journal of Biomedical Informatics, 144. doi:ARTN 10443710.1016/j.jbi.2023.104437         

    - Ten, F. W., Yuan, D., Jabareen, N., Phua, Y. J., Eils, R., Lukassen, S., & Conrad, C. (2023). resVAE ensemble: Unsupervised identification of gene sets in multi-modal single-cell sequencing data using deep ensembles. Front Cell Dev Biol, 11, 1091047. doi:10.3389/fcell.2023.1091047

    - Buergel, T., Steinfeldt, J., Ruyoga, G., Pietzner, M., Bizzarri, D., Vojinovic, D., Upmeier Zu Belzen, J., Loock, L., Kittner, P., Christmann, L., Hollmann, N., Strangalies, H., Braunger, J. M., Wild, B., Chiesa, S. T., Spranger, J., Klostermann, F., van den Akker, E. B., Trompet, S., Mooijaart, S. P., Sattar, N., Jukema, J. W., Lavrijssen, B., Kavousi, M., Ghanbari, M., Ikram, M. A., Slagboom, E., Kivimaki, M., Langenberg, C., Deanfield, J., Eils, R., & Landmesser, U. (2022). Metabolomic profiles predict individual multidisease outcomes. Nat Med, 28(11), 2309-2320. doi:10.1038/s41591-022-01980-3 

    - Loske, J., Rohmel, J., Lukassen, S., Stricker, S., Magalhaes, V., Liebig, J., Chua, R., Thurmann, L., Messingschlager, M., Seegebarth, A., Timmermann, B., Klages, S., Ralser, M., Sawitzki, B., Sander, L., Corman, V., Conrad, C., Laudi, S., Binder, M., Trump, S., Eils, R., Mall, M. A., & Lehmann, I. (2022). Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children. Nat Biotechnol, 40(3), 319-+. doi:10.1038/s41587-021-01037-9

    - Pietzner, M., Chua, R. L., Wheeler, E., Jechow, K., Willett, J. D. S., Radbruch, H., Trump, S., Heidecker, B., Zeberg, H., Heppner, F. L., Eils, R., Mall, M. A., Richards, J. B., Sander, L. E., Lehmann, I., Lukassen, S., Wareham, N. J., Conrad, C., & Langenberg, C. (2022). ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19. Nat Commun, 13(1), 4484. doi:10.1038/s41467-022-31999-6

    - Prokosch, H. U., Bahls, T., Bialke, M., Eils, J., Fegeler, C., Gruendner, J., Haarbrandt, B., Hampf, C., Hoffmann, W., Hund, H., Kampf, M., Kapsner, L. A., Kasprzak, P., Kohlbacher, O., Krefting, D., Mang, J. M., Marschollek, M., Mate, S., Muller, A., Prasser, F., Sass, J., Semler, S., Stenzhorn, H., Thun, S., Zenker, S., & Eils, R. (2022). The COVID-19 Data Exchange Platform of the German University Medicine. Stud Health Technol Inform, 294, 674-678. doi:10.3233/SHTI220554

    - Steinfeldt, J., Buergel, T., Loock, L., Kittner, P., Ruyoga, G., Zu Belzen, J. U., Sasse, S., Strangalies, H., Christmann, L., Hollmann, N., Wolf, B., Ference, B., Deanfield, J., Landmesser, U., & Eils, R. (2022). Neural network-based integration of polygenic and clinical information: development and validation of a prediction model for 10-year risk of major adverse cardiac events in the UK Biobank cohort. Lancet Digit Health, 4(2), e84-e94. doi:10.1016/S2589-7500(21)00249-1

    - Landmesser, U., Lehmann, I., & Eils, R. (2021). Hyperinflammation as underlying mechanism predisposing patients with cardiovascular diseases for severe COVID-19. European Heart Journal, 42(18), 1720-1721. doi:10.1093/eurheartj/ehab191

    *these authors contributed equally.     §corresponding author

    For a full publication list, please click here.

Cancer Bioinformatics

Naveed Ishaque recently started his own research group in the BIH unit of Roland Eils with research focus on applying computational approaches to understanding the basis of molecular biological heterogeneity in -omics data of human disease. They employ artificial intelligence and data science methods, not only to address the underlying causes of this heterogeneity, but also the interactions between different molecular -omics layers. The team has a strong specialization in the application area of oncology, but is also very interested in immunology and neurodegenerative diseases. 

A better understanding of global and local patterns in biological data allows for better differentiation of the mechanistics behind biological and molecular processes from technical noise. As such, the team establishes close ties with experimental collaborators who are able to provide large-scale and high-dimensional datasets profiled using state-of-the-art and exotic profiling techniques, including recent technological advances that are able to resolve single cell, spatial, temporal and genetic heterogeneity.

Please visit https://www.hidih.org/research/computational-oncology for further details on ongoing projects in cancer multiomics and precision oncology, Immunology and allergies, or spatially resolved transcriptomics.

Selected Publications Naveed Ishaque, Cancer Bioinformatics

  • Selected Publications Naveed Ishaque, Cancer Bioinformatics

    - Müller-Bötticher N., Sahay S., Eils R. et al. (2025). SpatialLeiden: spatially aware Leiden clustering. Genome Biol 26, 24. https://doi.org/10.1186/s13059-025-03489-7

    - Müller-Bötticher N., Tiesmeyer S., Eils R., Ishaque N. (2025). Sainsc: A Computational Tool for Segmentation-Free Analysis of In Situ Capture Data. Small Methods 9, 2401123. https://doi.org/10.1002/smtd.202401123

    - Nonn O., Debnath O., Valdes D. S. et.al. (2025). Senescent syncytiotrophoblast secretion during early onset preeclampsia. Hypertension 82 (5), 787-799. https://doi.org/10.1161/HYPERTENSIONAHA.124.23362

    - Tiesmeyer S., Müller-Bötticher N., Malt A. et. al. (2025). 2D, or not 2D? Investigating Vertical Signal Integrity of Tissue Slices. bioRxiv.01.13.632601. https://doi.org/10.1101/2025.01.13.632601

    - Garrard C., Heil K.F., Aspromonte M.C. et al. (2025). Fostering and sustaining collaborative innovation: Insights from ELIXIR Europe's life science Communities [version 1; peer review: 2 approved]. F1000Research 14(ELIXIR):884. https://doi.org/10.12688/f1000research.168288.1

    - Nina Hensel*, Zuguang Gu*, Sagar*, Dominik Wieland, Katharina Jechow, Janine Kemming, Sian Llewellyn-Lacey, Emma Gostick, Oezlem Sogukpinar, Florian Emmerich, David A. Price, Bertram Bengsch, Tobias Boettler, Christoph Neumann-Haefelin, Roland Eils, Christian Conrad, Ralf Bartenschlager, Dominic Grün, Naveed Ishaque§, Robert Thimme§ & Maike Hofmann§ (2021). Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection. Nature Immunology  https://doi.org/10.1038/s41590-020-00817-w

    - Trump, S.*, Lukassen, S.*, Anker, M.S.*, Chua, R.L.*, Liebig, J.*, Thurmann, L.*, Corman, V.M.*, Binder, M.*, Loske, J., Klasa, C., Krieger, T., Hennig, B.P., Messingschlager, M., Pott, F., Kazmierski, J., Twardziok, S., Albrecht, J.P., Eils, J., Hadzibegovic, S., Lena, A., Heidecker, B., Burgel, T., Steinfeldt, J., Goffinet, C., Kurth, F., Witzenrath, M., Volker, M.T., Muller, S.D., Liebert, U.G., Ishaque, N., Kaderali, L., Sander, L.E., Drosten, C., Laudi, S.§, Eils, R.§, Conrad, C.§, Landmesser, U.§, & Lehmann, I.§ (2020). Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19. Nature Biotechnology doi: 10.1038/s41587-020-00796-1

    - Ahmed Sadik*, Luis F Somarribas Patterson*, Selcen Öztürk*, Soumya R Mohapatra, Verena Panitz, Philipp F Secker, Pauline Pfänder, Stefanie Loth, Heba Salem, Mirja Tamara Prentzell, Bianca Berdel, Murat Iskar, Erik Faessler, Friederike Reuter, Isabelle Kirst, Verena Kalter, Kathrin I Foerster, Evelyn Jäger, Carina Ramallo Guevara, Mansour Sobeh, Thomas Hielscher, Gernot Poschet, Annekathrin Reinhardt, Jessica C Hassel, Marc Zapatka, Udo Hahn, Andreas von Deimling, Carsten Hopf, Rita Schlichting, Beate I Escher, Jürgen Burhenne, Walter E Haefeli, Naveed Ishaque, Alexander Böhme, Sascha Schäuble, Kathrin Thedieck, Saskia Trump§, Martina Seiffert§, Christiane A Opitz§ (2020).  IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression. Cell https://doi.org/10.1016/j.cell.2020.07.038

    - Park, J.*, Choi, W.*, Tiesmeyer, S., Long, B., Borm, L.E., Garren, E., Nguyen, T.N., Codeluppi, S., Schlesner, M., Tasic, B., Eils, R.§ & Ishaque, N.§ (2019). Segmentation-free inference of cell types from in situ transcriptomics data. bioRxiv, doi: 10.1101/800748 

    - Mallm, J.-P.*, Iskar, M.*, Ishaque, N.*, Klett, L.C., Kugler, S.J., Muino, J.M., Teif, V.B., Poos, A.M., Großmann, S., Erdel, F., Tavernari, D., Koser, S.D., Schumacher, S., Brors, B., König, R., Remondini, D., Vingron, M., Stilgenbauer, S., Lichter, P., Zapatka, M., Mertens, D.§ & Rippe, K.§ (2019). Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks. Molecular Systems Biology, 22;15(5):e8339. doi: 10.15252/msb.20188339

    - Ishaque, N.*, Abba, M.L.*, Hauser, C., Patil, N., Paramasivam, N., Huebschmann, D., Leupold, J.H., Balasubramanian, G.P., Kleinheinz, K., Toprak, U.H., Hutter, B., Benner, A., Shavinskaya, A., Zhou, C., Gu, Z., Kerssemakers, J., Marx, A., Moniuszko, M., Kozlowski, M., Reszec, J., Niklinski, J., Eils, J., Schlesner, M., Eils, R., Brors, B. & Allgayer, H.§ (2018). Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer. Nature Communications, 9(1), 4782. doi: 10.1038/s41467-018-07041-z

    - Zuguang Gu, Roland Eils, Matthias Schlesner & Naveed Ishaque (2018). EnrichedHeatmap: an R/Bioconductor package for comprehensive visualization of genomic signal associations. BMC Bioinformatics https://doi.org/10.1186/s12864-018-4625-x

    - Tiesmeyer, S., Sahay, S., Muller-Botticher, N., Eils, R., Mackowiak, S. D., & Ishaque, N. (2022). SSAM-lite: A Light-Weight Web App for Rapid Analysis of Spatially Resolved Transcriptomics Data. Frontiers in Genetics, 13, 7. doi:10.3389/fgene.2022.785877

    - Krieger, T. G., Le Blanc, S., Jabs, J., Ten, F. W., Ishaque, N., Jechow, K., Debnath, O., Leonhardt, C. S., Giri, A., Eils, R., Strobel, O., & Conrad, C. (2021). Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy. Nat Commun, 12(1), 13. doi:10.1038/s41467-021-26059-4

    - Park, J., Choi, W., Tiesmeyer, S., Long, B., Borm, L. E., Garren, E., Nguyen, T. N., Tasic, B., Codeluppi, S., Graf, T., Schlesner, M., Stegle, O., Eils, R., & Ishaque, N. (2021). Cell segmentation-free inference of cell types from in situ transcriptomics data. Nat Commun, 12(1), 13. doi:10.1038/s41467-021-23807-4

Health Data

Health Data

The Heath Data team focusses on processes in medical informatics and bioinformatics. The team works on the automatization of computational workflows in biomedical research, provides data managing tools and infrastructures that support the fast transfer of new research results into healthcare. A fundamental challenge of a digital healthcare environment is the growing amount of sensitive patient data, e.g., created by smart wearables or whole genome sequencing data. Handling and processing of such huge data sets in daily routine diagnostics requires new infrastructures and IT solutions. Therefore, the team is also working on large-scale IT and cloud solutions, in particular the de.NBI cloud. The Health Data team is located in both Berlin and Heidelberg. Please visit https://www.hidih.org/research/health-data for further information.

Selected Publications Health Data

  • Selected Publications Health Data

    - Braun M., Kanitz A., Krüger J., Kraatz L., Miranda J, Schelp C., … Twardziok S. (2025). Secure Processing Environments as a Service in the de.NBI Cloud. doi: 10.37044/osf.io/pzmue_v1

    - Raab R., Küderle A., Zakreuskaya A., ... Eils R, Wagener H., Eskofier B. (2023). Federated electronic health records for the European Health Data Space. Lancet Digital Health, Vol. 5, Issue 11. doi: 10.1016/S2589-7500(23)00156-5 

    - Canham S., Ohman C., Demotes-Mainard et al. (2023) . Final HealthyCloud Strategic Agenda for the Health Research Innovation Cloud. Zenodo. doi: 10.5281/ZENODO.7331831 

    - David R., Rybina A., Burel JM., Heriche JK.; Audergon P.,  et al.  (2023). "Be sustainable": EOSC-Life recommendations for implementation of FAIR principles in life science data handling. EMBO Journal, doi: 10.15252/embj.2023115008 

    - ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium (2020). Pan-cancer Analysis of Whole Genomes, Nature, 578(7793), 82-93, doi: 10.1038/s41586-020-1969-6

    - Yakneen, S.§, Waszak, S.M., PCAWG Technical Working Group, Gertz, M., Korbel, J. O.§, PCAWG Consortium (2020). Bulter enables rapid cloud-based analysis of thousands of human genomes. Nature Biotechnology, Epub ahead of print, doi: 10.1038/s41587-019-0360-3

    - Ishaque, N.*, Abba, M.L.*, Hauser, C., Patil, N., Paramasivam, N., Huebschmann, D., Leupold, J.H., Balasubramanian, G.P., Kleinheinz, K., Toprak, U.H., Hutter, B., Benner, A., Shavinskaya, A., Zhou, C., Gu, Z., Kerssemakers, J., Marx, A., Moniuszko, M., Kozlowski, M., Reszec, J., Niklinski, J., Eils, J., Schlesner, M., Eils, R., Brors, B. & Allgayer, H.§ (2018). Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer. Nature Communications, 9(1), 4782. doi: 10.1038/s41467-018-07041-z

    - Gröbner, S.N.*, Worst, B.C.*, Weischenfeldt, J., Buchhalter, I., Kleinheinz, K., Rudneva, V.A., Johann, P.D., Balasubramanian, G.P., Segura-Wang, M., Brabetz, S., Bender, S., Hutter, B., Sturm, D., Pfaff, E., Hubschmann, D., Zipprich, G., Heinold, M., Eils, J., Lawerenz, C., Erkek, S., Lambo, S., Waszak, S., Blattmann, C., Borkhardt, A., Kuhlen, M., Eggert, A., Fulda, S., Gessler, M., Wegert, J., Kappler, R., Baumhoer, D., Burdach, S., Kirschner-Schwabe, R., Kontny, U., Kulozik, A.E., Lohmann, D., Hettmer, S., Eckert, C., Bielack, S., Nathrath, M., Niemeyer, C., Richter, G.H., Schulte, J., Siebert, R., Westermann, F., Molenaar, J.J., Vassal, G., Witt, H., Burkhardt, B., Kratz, C.P., Witt, O., van Tilburg, C.M., Kramm, C.M., Fleischhack, G., Dirksen, U., Rutkowski, S., Fruhwald, M., von Hoff, K., Wolf, S., Klingebiel, T., Koscielniak, E., Landgraf, P., Koster, J., Resnick, A.C., Zhang, J., Liu, Y., Zhou, X., Waanders, A.J., Zwijnenburg, D.A., Raman, P., Brors, B., Weber, U.D., Northcott, P.A., Pajtler, K.W., Kool, M., Piro, R.M., Korbel, J.O., Schlesner, M., Eils, R., Jones, D.T.W., Lichter, P., Chavez, L.§, Zapatka, M.§, Pfister, S.M.§ (2018). The landscape of genomic alterations across childhood cancers. Nature, 559(7714), 321-327, doi: 10.1038/s41586-018-0167-2

    - Reisinger, E.§, Genthner, L., Kerssemakers, J., Kensche, P., Borufka, S., Jugold, A., Kling, A., Prinz, M., Scholz, I., Zipprich, G., Eils, R., Lawerenz, C., Eils, J. (2017). OTP: An automatized system for managing and processing NGS data. Journal of Biotechnology, 10(261), 53-62, doi: 10.1016/j.jbiotec.2017.08.006

    - Raab, R., Kuderle, A., Zakreuskaya, A., Stern, A. D., Klucken, J., Kaissis, G., Rueckert, D., Boll, S., Eils, R., Wagener H., & Eskofier, B. M. (2023). Federated electronic health records for the European Health Data Space. Lancet Digit Health, 5(11), e840-e847. doi:10.1016/S2589-7500(23)00156-5

    *these authors contributed equally.     §corresponding author

Research group Eils - Team
Head of Center & Project Management Dr. Friedrich, Alexandra [email protected] 030450643106
Project Manager Dr. Canitz, Carsten [email protected] 030450581070
Project Manager Müller, Franziska [email protected] 030450543085
Project Manager Dr. Schubert, Vivien [email protected] 030450543144
Project Manager Dr. Schütz, Tatjana [email protected] 030450543151
Project Manager Seidemann, Britta [email protected] 030450543131
Project Manager Wächter, Sarah [email protected] 030450543139
Personal Assistent of Prof. Dr. Roland Eils Zimanji, Ann-Kathrin [email protected] 030450643088
Artificial Intelligence
Founding Director Center of Digital Health Prof. Dr. Eils, Roland [email protected] 030450543084
Junior Research Group Leader Dr. Wild, Benjamin [email protected]  
Research Assistant Bodur, Leylanur [email protected]  
Postdoc Cen, Xiaoping [email protected]  
PhD Student Duan, Qihao [email protected]  
PhD Student (shared position with Maik Pietzner) Kohleick, Leonhard [email protected]  
Student Assistant Kronenberg, Noel Leon [email protected]  
Medical Student Nennen, Luca Marc [email protected]  
PhD Student Rheude, Tillmann [email protected]  
PhD Student Upmeier zu Belzen, Julius Valten [email protected]  
PhD Student von Arnim, Georg [email protected]  
Student von Lipinski, Vincent-Noah [email protected]  
PhD Student Wang, Oscar Oscar.wang@bih-charite  
Health Data | Cloud & IT, Data Management, Medical Informatics
Group Leader Cloud & IT Wagener, Harald [email protected] 030450543087
Reseach Assistant Bauer, Jochen [email protected]  
IT-System Integration Boshof, Max Jonas [email protected]  
Cloud Developer Braun, Martin [email protected] 030450543107
Research Assistant Buggedei, Christian [email protected]  
System Integration Trainee Stöwer, David Julian [email protected]  
IT-System Integration Mathis, Jakob [email protected]  
IT Schneider, Stefan [email protected] 030450543111
Systemadministrator Cloud Ten, Foo Wei [email protected]  
Health Data | Cloud & IT, Data Management, Medical Informatics (Teil 2)
Group Leader Data Management Dr. Twardziok, Sven [email protected] 030450543105
Data Manager Dr. Jentsch, Marcel [email protected] 030450543105
Research Assistant Kraatz, Landfried [email protected]  
Bioinformatician Dr. Schneider-Lunitz, Valentin [email protected] 030450543137
Software Developer Strubel, Philipp [email protected] 030450543095
Data Manager Taron, Ulrike [email protected] 030450543135
System Integration Trainee Pieper, Karl-Yannik [email protected]  
Health Data | Cloud & IT, Data Management, Medical Informatics (Teil 3)
Group Leader Medical Informatics Dr. Meyer zum Büschenfelde, Dirk [email protected] 030450543145
Dual Student Neubauer, Adrian [email protected]  
Cooperation partner Kohler, Severin [email protected]  
Cancer Bioinformatics
Group Leader Cancer Bioinformatics Ishaque, Naveed, PhD [email protected] 030450543096
PhD Student Du, Peiru [email protected]  
Postdoc Gavriilidis, Georgios [email protected]  
PhD Student Huang, Kaixin [email protected]  
PhD Student Jiang, Yiheng [email protected]  
PhD Student Malt, Alexander [email protected] 030450543125
Medical Doctoral Student Last, Timon timon.last@charite.de  
PhD Student Wang, Fei [email protected]  
PhD Student Xiang, Yizhen [email protected]  
Medical Doctoral Student Zhang, Jianpeng [email protected]  
PhD Student Wang, Haoxin [email protected]  
Medical Omics
Group Leader Medical Omics Dr. Lukassen, Sören [email protected] 030450543102
Research Assistant Eckhoff, Leonard [email protected]  
Research Assistant Ensminger, Eric [email protected]  
Research Assistant Herzler, Florian [email protected]  
PhD Student Liu, Ding Ming [email protected]  

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