BCRT
Translational Immunocardiology
Sophie Van Linthout
Our research is focused at exploring the role of the innate and adaptive immunity in the pathogenesis of non-ischemic heart failure with main interest in inflammatory cardiomyopathy and heart failure with preserved ejection fraction. The relevance of extra-cardiac versus cardiac inflammation on the pathogenesis of heart failure is investigated. In addition, our research is directed at the search for novel therapeutic targets as well as the evaluation of repurposed anti-inflammatory and immunomodulatory strategies.
HFA
HFA Board member
Chair of the Committee
on Basic and Translational Research
ESC
Nucleus Member
DGK
Chair-elect of the German Society of Cardiology
WG on Myocardial Function and Energetics
Focus
In view of translational research, patient materials of specific heart failure cohorts are analyzed and identified targets and therapies evaluated in experimental models.
Focus
- NLRP3 inflammasome and S100A8/A9 alarmins
- (cardiac) fibroblasts as inflammatory supporter cells
- cardiosplenic axis
- interorgan interaction
- mechanosensitive pathways
- cancer therapy-related cardiotoxicity
- immunomodulating strategies: pharmacological and cell-based
Publications
Van Linthout S - Search Results - PubMed (nih.gov)
- Pesce M, Duda GN, Forte G, Girao H, Raya A, Roca-Cusachs P, Sluijter JPG, Tschöpe C, Van Linthout S.
Cardiac fibroblasts and mechanosensation in heart development, health and disease - PubMed (nih.gov)
Nat Rev Cardiol, 2022. - Matz I, Pappritz K, Springer J, Van Linthout S.
Left ventricle- and skeletal muscle-derived fibroblasts exhibit a differential inflammatory and metabolic responsiveness to interleukin-6 - PubMed (nih.gov)
Front Immunol, 2022. - Pappritz K, Lin J, El-Shafeey M, Fechner H, Kühl U, Alogna A, Spillmann F, Elsanhoury A, Schulz R, Tschöpe C1, Van Linthout S1.
Colchicine prevents disease progression in viral myocarditis via modulating the NLRP3 inflammasome in the cardiosplenic axis - PubMed (nih.gov)
ESC Heart Fail 2022 - Tschöpe C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB, Hare JM, Heidecker B, Heymans S, Kelle S, Klingel K, Parwani AS, Spillmann F, Starling RC, Tsutsui H, Seferovic P, Van Linthout S.
Myocarditis and inflammatory cardiomyopathy: current evidence and future directions - PubMed (nih.gov)
Nat Rev Cardiol 2021