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Univ. Prof. Dr. Irina Lehmann

BIH-Professorin für „Umweltepigenetik und Lungenforschung“

Contact information
Address:Kapelle-Ufer 2
10117 Berlin

Contact for inquirie

Jasmin Thierfelder-Matuszak
Team Assistant / Project Coordination
Kapelle-Ufer 2
10117 Berlin
+49 30 450 543 146

In longitudinal cohort and patient studies we combine genome-wide epigenetic analyses with system medicine approaches to identify predictive markers for disease. Research in this field is driven by two major aims: the early identification of high risk patients and the characterization of sensitive time windows and subpopulations as basis for individualized prevention strategies.

There is strong evidence that many diseases developed during adulthood might have a origin in the childhood period. We are therefore are particularly interested in epigenetic programming during early life with a focus on lung diseases and early childhood asthma.

Research focus

  • Epigenetics of childhood asthma
  • Early childhood imprinting of asthma/allergies, overweight and behavioral disorders
  • Epigenetic alterations by particulate air pollution

Selected publications


Epigenetic changes with increased fine dust pollution

There is strong evidence for particulate matter caused adverse health effects including cardiovascular diseases, lung inflammation and metabolic disorders. Some recent studies report epigenetic modifications such as alterations of DNA methylation in association with particle exposure. However, available data in this field are sparse and inconsistent. To close this gap of knowledge, this project will provide comprehensive, genome-wide data on DNA-methylation and microRNA-expression pattern based on sequencing approaches from individuals exposed to particulate matter. The final aim is to identify epigenetic marker signatures predictive for later disease development.

Funded by the Umweltbundesamt (FKZ 3717 62b204 0)
Funding duration: November 2018 – April 2021
Volume: 1, 36 Mio €

Project coordination: Prof. Dr. Irina Lehmann / Dr. Saskia Trump (Molekular Epidemiology Unit, BIH and Charité)

Co-operation partner:

Prof. Dr. Roland Eils and Dr. Naveed Ishaque (BIH and Charité Centre for Digital Health)
Dr. Tomasz Zimojtel (Core Unit Genomics at BIH)
Dr. Dominik Lermen and Dr. Martina Bartel-Steinbach (Fraunhofer-Institute for Biomedical Engeneering IBMT)

Staff members

  • [Translate to englisch:]

    Univ. Prof. Dr. Irina Lehmann


  • Dr. Saskia Trump

    Stellv. Leiterin

  • Dr. Loreen Thürmann


  • Dr. Ismail El-Shimy Hassanin


  • Anke Seegebarth

    Technische Assistentin

  • Dr. Jasmin Thierfelder-Matuszak

    Team Assistant / Project Coordination

  • Marey Messingschlager


  • Jennifer Loske


  • Laura Matzner

    PhD Student

  • Sophie McEwen

    PhD Student