Blood vessels form extensive tubular networks that nurture all body tissues. Aberrant vessel growth and function are hallmarks of cancer and inflammatory diseases, contributing to disease pathogenesis. Therapeutic approaches to inhibit pathologic angiogenic responses are used in the clinic, but limited efficacy and resistance are unresolved challenges. Recent insights in vascular biology have put metabolism into the spotlight and revealed how vascular cells use their metabolism to form functional networks. The principles that arise from these studies illuminate new perspectives on blood vessel development and function, the translation of which might overcome the current barriers of angiogenesis-based medicine.
Michael Potente, BIH Professor for Translational Vascular Biomedicine, was born in 1976 in Aachen, Germany and studied human medicine at the Universities of Frankfurt and Toronto (Canada). During his experimental doctoral thesis at the University of Frankfurt, which he completed in 2003, he already dealt with blood vessels. Subsequently, he worked both scientifically as a post-doc at the Institute for Cardiovascular Regeneration and clinically as a physician at the Clinic for Cardiology of the Goethe University Frankfurt, where he habilitated in internal medicine in 2013. In 2012 he was appointed to a Max Planck Research Group at the Max Planck Institute for Heart and Lung Research in Bad Nauheim. Potente has already received numerous awards, including an ERC Starting and Consolidator Grant and an EMBO Young Investigator Award. He has published his research results in top-class journals and is a reviewer for numerous international scientific journals.
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