Integrative Vascular Biology
Holger Gerhardt
The Integrative Vascular Biology Laboratory aims to unravel the fundamental principles and molecular/genetic regulation of functional vascular network formation in development and disease.
The Integrative Vascular Biology Laboratory aims to unravel the fundamental principles and molecular/genetic regulation of functional vascular network formation in development and disease.
Chronic low back pain is a significant public health problem in industrialized society. The intact spine carries the upper body and external loads, allows motion in a physiological range and protects the spinal cord. These different demands necessitate a high degree of complexity with various sources for disorders and pain. The BIH - Julius Wolff…
Our research focuses on molecular changes in the development of various tumors. We now want to use bioinformatic and experimental methods to better understand the early development of cancer in order to be able to intervene and prevent it in the long term.
Our motivation is to address fundamental biological questions of human immunology and translate them into innovative therapies. In this respect, the core interest of our laboratory lies in the discovery of new applications of antibodies and B cells to treat and prevent challenging human diseases.
Defects in musculoskeletal tissues, e.g. in consequence of a trauma, do not always heal spontaneously but require surgical intervention. Biomaterials implanted into the defect region have to potential to support the healing process. We investigate the interaction between cells, their surrounding extracellular matrix and biomaterials for the…
Both mechanical and biological processes work together to determine the outcome of musculoskeletal regeneration. Whilst many of the biological factors have been identified and some even brought into clinical practice (BMP's, PDGF, IGF, etc.), the impact of the mechanical environment and the role of the immune system are only recently taken into…
The Potente laboratory focuses on the vasculature—the largest organ in the human body. We study how vascular networks develop and remodel and how their function becomes abnormal in disease states.
We investigate clinical pathophysiological metabolic changes of muscle and fat tissue in chronic diseases. In clinical work, cardiovascular knowledge is combined with acute therapy and stroke rehabilitation. Our research is focused on metabolic pathophysiology, which leads to weight loss and loss of muscle mass, cachexia and sarcopenia in chronic…
Genetic sequencing, an essential method in life science, is mainly driven by fluorescence imaging. In the advent of spatial imaging and in situ sequencing directly on cells and human tissues, we aim to apply latest deep learning and microscopic automation for translational medicine and molecular pathology. This includes fast optical imaging, single…