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Bioengineering 3D Microenvironments to Develop Clinically Relevant In Vitro Biofilm Models

Arguably motivated by their medical implications, biofilm research has grown exponentially over the last decades, providing insights on the mechanistic processes that lead to biofilm formation. However, current biofilm research is mostly rooted in simplistic in vitro models that fail to capture the physiological growth conditions of biofilms in vivo, often discount the composition and properties of the host microenvironment and overlook the biofilm-host interactions.  The differences between lab-grown- and biofilms that form in clinical settings raise concerns about the clinical relevance of these models, particularly with respect to phenotypic profiles, virulence, and antimicrobial resistance, and they essentially impede bench-to-bedside translatability. In this talk, we examine the most recent biofilm literature and discuss the prerequisite for the development and characterization of biofilm models that better mimic the clinical scenario, and we propose an interdisciplinary outlook of how to bioengineer biofilms in vitro by converging tissue engineering concepts and tools.

About the Speaker

Dietmar W. Hutmacher is Distinguished Professor and Chair of Regenerative Medicine at the Queensland University of Technology and is the Founding Director of the Max Planck Queensland Centre (MPQC) for the Materials Science of Extracellular Matrices.

After building a successful career for more then 10 years in industry, Hutmacher decided to pursue his long term aspiration to foster a legacy in academia. Hence, his academic career is less than 25 years young, yet he is one of the world's most highly cited researchers with substantial influence across interdisciplinary research fields. In 2018, he was awarded the Ramaciotti Medal for Excellence in Biomedical Research and granted a Humboldt Life Time Research Award while being listed as one of the 10 scientist/bioengineers (and the only non-US academic) who will shape the Biofabrication landscape in 2019 in a survey report of the world-leading Advanced Regenerative Manufacturing Institute. In 2023 he was listed again “Highly Cited Researcher” (Clarivate Analytics).


February 13, 2024
  9:00 am: Talk
10:00 am: 1:1 Get-together
>> If you are interested in meeting Prof. Hutmacher 1:1, please get in contact with us.

BIH Center for Regenerative Therapies (BCRT)
Auditorium @Cranach House
Föhrerstr. 15, 13353 Berlin

Please register by sending an email to: contact@b-crt.de

[Translate to englisch:]


Dr. Anne-Christin Schöne

Research Coordination BCRT

Telefon:+49 (0)30 450 539 406