Publikationen der AG Medizininformatik

Holub P, Müller H, Bíl T, Pireddu L, Plass M, Prasser F, Schlünder I, Zatloukal K, Nenutil R, Brázdil T. Privacy risks of whole-slide image sharing in digital pathology. Nat Commun. 2023 May 4;14(1):2577. doi: 10.1038/s41467-023-37991-y. PMID: 37142591; PMCID: PMC10160114.

Müller A, Christmann LS, Kohler S, Eils R, Prasser F. Machine Learning for Medical Data Integration. Stud Health Technol Inform. 2023 May 18;302:691-695. doi: 10.3233/SHTI230241. PMID: 37203471.

Baum L, Johns M, Poikela M, Möller R, Ananthasubramaniam B, Prasser F. Data integration and analysis for circadian medicine. Acta Physiol (Oxf). 2023 Apr;237(4):e13951. doi: 10.1111/apha.13951. Epub 2023 Feb 28. PMID: 36790321.

Johns M, Meurers T, Wirth FN, Haber AC, Müller A, Halilovic M, Balzer F, Prasser F. Data Provenance in Biomedical Research: Scoping Review. J Med Internet Res. 2023 Mar 27;25:e42289. doi: 10.2196/42289. PMID: 36972116; PMCID: PMC10132013.

Pilgram L, Eberwein L, Jensen BO, Jakob CEM, Koehler FC, Hower M, Kielstein JT, Stecher M, Hohenstein B, Prasser F, Westhoff T, de Miranda SMN, Vehreschild MJGT, Lanznaster J, Dolff S; LEOSS study group. SARS-CoV-2 infection in chronic kidney disease patients with pre-existing dialysis: description across different pandemic intervals and effect on disease course (mortality). Infection. 2023 Feb;51(1):71-81. doi: 10.1007/s15010-022-01826-7. Epub 2022 Apr 29. PMID: 35486356; PMCID: PMC9052729.

Pilgram L, Schäffner E, Eckardt KU, Prasser F; GCKD Investigators. Utility-Preserving Anonymization in a Real-World Scenario: Evidence from the German Chronic Kidney Disease (GCKD) Study. Stud Health Technol Inform. 2023 May 18;302:28-32. doi: 10.3233/SHTI230058. PMID: 37203603.

Strech D, Haven T, Madai VI, Meurers T, Prasser F. Generating evidence on privacy outcomes to inform privacy risk management: A way forward? J Biomed Inform. 2023 Jan;137:104257.

Mansmann U, Locher C, Prasser F, Weissgerber T, Sax U, Posch M, Decullier E, Cristea IA, Debray TPA, Held L, Moher D, Ioannidis JPA, Ross JS, Ohmann C, Naudet F. Implementing clinical trial data sharing requires training a new generation of biomedical researchers. Nat Med. 2023 Feb 2.

Koll CEM, Hopff SM, Meurers T, Lee Ch, Kohls M, Stellbrink C, Thibeault C, Reinke L, Steinbrecher S, Schreiber S, Mitrov L, Frank S, Miljukov O, Erber J, Hellmuth JC, Reese JP, Steinbeis F, Bahmer T, Hagen M, Meybohm P, Hansch S, Vadász I, Krist L, Jiru-Hillmann S, Prasser F, Vehreschild JJ, NAPKON Study Group. Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients. Scientific Data, 2022 Dec 21;9(1):776. doi: 10.1038/s41597-022-01669-9.

Wirth FN, Kussel T, Müller A, Hamacher K, Prasser F. EasySMPC: a simple but powerful no-code tool for practical secure multiparty computation. BMC Bioinformatics 23 (1), 1-17, 2022. https://doi.org/10.1186/s12859-022-05044-8.

Haber AC, Sax U, Prasser F. Open Tools for Quantitative Anonymization of Tabular Phenotype Data: Literature Review. Brief Bioinformatics. 2022; bbac440. doi: 10.1093/bib/bbac440. 

Kaabachi B, Despraz J, Meurers T, Prasser F, Raisaro JL. Generation and Evaluation of Synthetic Data in a University Hospital Setting. Stud Health Technol Inform. 2022 May 25;294:141-142. doi: 10.3233/SHTI220420. PMID: 35612040.

Katsch F, Hussein R, Sabutsch S, Prenner H, Prasser F, Stamm T, Duftschmid G. Extending the Austrian National EHR System with Patient-Reported Outcome Data. Stud Health Technol Inform. 2022 May 25;294:561-562. doi: 10.3233/SHTI220523. PMID: 35612144.

Prokosch HU, Bahls T, Bialke M, Eils J, Fegeler C, Gruendner J, Haarbrandt B, Hampf C, Hoffmann W, Hund H, Kampf M, Kapsner LA, Kasprzak P, Kohlbacher O, Krefting D, Mang JM, Marschollek M, Mate S, Müller A, Prasser F, Sass J, Semler S, Stenzhorn H, Thun S, Zenker S, Eils R. The COVID-19 Data Exchange Platform of the German University Medicine. Stud Health Technol Inform. 2022 May 25;294:674-678. doi: 10.3233/SHTI220554. PMID: 35612174.

Neves DT, Alves J, Naik MG, Proença AJ, Prasser F. From missing data imputation to data generation. Journal of Computational Science 2022:101640. doi.org/10.1016/j.jocs.2022.101640. 

Sommer KK, Amr A, Bavendiek U, Beierle F, Brunecker P, Dathe H, Eils J, Ertl M, Fette G, Gietzelt M, Heidecker B, Hellenkamp K, Heuschmann P, Hoos JDE, Kesztyüs T, Kerwagen F, Kindermann A, Krefting D, Landmesser U, Marschollek M, Meder B, Merzweiler A, Prasser F, Pryss R, Richter J, Schneider P, Störk S, Dieterich C. Structured, Harmonized, and Interoperable Integration of Clinical Routine Data to Compute Heart Failure Risk Scores. Life 2022; 12(5):749. doi.org/10.3390/life12050749.

Pilgram L, Eberwein L, Jensen BEO, Jakob CE, Koehler FC, Hower M, Kielstein JT, Stecher M, Hohenstein B, Prasser F, Westhoff T, Nunes de Miranda SM, Vehreschild MJGT, Lanznaster J, Dolff S, on behalf of the LEOSS study group. SARS-CoV-2 infection in chronic kidney disease patients with pre-existing dialysis: description across different pandemic intervals and effect on disease course (mortality). Infection 2022, 1-11. doi.org/10.1007/s15010-022-01826-7.

Buchner B, Haber A, Hahn H, Kusch H, Prasser F, Sax U, Schmidt CO. Das Modell der Datentreuhand in der medizinischen Forschung. Datenschutz und Datensicherheit 45, 806–810 (2021). DOI: 10.1007/s11623-021-1534-y

Lawson J, Cabili MN, Giselle Kerry, Boughtwood T, Thorogood A, Alper P, Bowers SR, Boyles RR, Brookes AJ, Brush M, Burdett T, Clissold H, Donnelly S, Dyke SOM, Freeberg MA, Haendel MA, Hata C, Holub P, Jeanson F, Jene A, Kawashima M, Kawashima S, Konopko M, Kyomugisha I, Li H, Linden M, Rodriguez LL, Morita M, Mulder N, Muller J, Nagaie S, Nasir J, Ogishima S, Wang VO, Paglione LD, Pandya RN, Parkinson H, Philippakis AA, Prasser F, Rambla J, Reinold K, Rushton GA, Saltzman A, Saunders G, Sofia HJ, Spalding JD, Swertz MA, Tulchinsky I, van Enckevort EJ, Varma S, Voisin C, Yamamoto N, Yamasaki C, Zass L, Guidry Auvil JM, Nyrönen TH, Courtot M. The Data Use Ontology to streamline responsible access to human biomedical datasets. Cell Genomics 2021; 1(2):100028. DOI:10.1016/j.xgen.2021.100028

Pilgram L, Schons M, Jakob CEM, Claßen AY, Franke B, Tscharntke L, Schulze N, Fuhrmann S, Sauer G, Nunes de Miranda SM, Prasser F, Stecher M, Vehreschild JJ. Die COVID-19 Pandemie als Herausforderung und Chance für Register in der Versorgungsforschung: Erfahrungen aus Lean European Open Survey on SARS-CoV-2 Infected Patients (LEOSS). Gesundheitswesen 2021; 83(S 01): S45-S53. DOI: 10.1055/a-1655-8705.

Meurers T, Bild R, Do KM, Prasser F. A scalable software solution for anonymizing high-dimensional biomedical data. Gigascience 2021 Oct 4;10(10):giab068.

Wirth FN, Meurers T, Johns M, Prasser F. Privacy-preserving data sharing infrastructures for medical research: systematization and comparison. BMC Medical Informatics and Decision Making. (2021) 21:242.

Fluck J, Lindstädt B, Ahrens W, Beyan O, Buchner B, Darms J, Depping R, Dierkes J, Neuhausen H, Müller W, Zeeb H, Golebiewski M, Löffler M, Löbe M, Meineke F, Klammt S, Fröhlich H, Hahn H, Schulze M, Pischon T, Nöthlings U, Sax U, Kusch H, Grabenhenrich L, Schmidt CO, Waltemath D, Semler S, Gehrke J, Kirsten T, Praßer F, Thun S, Wieler L, Pigeot I. NFDI4Health – Nationale Forschungsdateninfrastruktur für personenbezogene Gesundheitsdaten. Bausteine Forschungsdatenmanagement. 2 (Juli 2021), 72–85. DOI: 10.17192/bfdm.2021.2.8331.

Stamm T, Bott N, Thwaites R, Mosor E, Andrews MR, Borgdorff J, Cossio-Gil Y, de Portu S, Ferrante M, Fischer F, Hameed F, Hazelzet J, Hopkins D, Kalra D, Metcalfe T, Molero E, Newson R, Patalano F, Prasser F, Rose M, Lindskov MS, Soderberg J, Strammiello V, van de Poll L, Styliadou M. Building a Value-Based Care Infrastructure in Europe: The Health Outcomes Observatory. NEJM Catalyst Innovations in Care Delivery. 2021 Jun 9;2(3).

Johns M, Müller A, Wirth FN, Prasser F. A Comprehensive Portal for Clinical and Translational Data Warehouses. Studies in Health Technology and Informatics 2021 May 27;281:462-466. doi: 10.3233/SHTI210201. 

Pilgram L, Eberwein L, Wille K, Koehler FC, Stecher M, Rieg S, Kielstein JT, Jakob CEM, Rüthrich M, Burst V, Prasser F, Borgmann S, Müller RU, Lanznaster J, Isberner N, Tometten L, Dolff S & The LEOSS Study Group. Clinical course and predictive risk factors for fatal outcome of SARS-CoV-2 infection in patients with chronic kidney disease. Infection 2021 Apr 13;1-13. doi: 10.1007/s15010-021-01597-7.

Huber MK, Raichle C, Lingor P, Synofzik M, Borgmann S, Erber J, Tometten L, Rimili W, Dolff S, Wille K, Knauss S, Piepel C, Lanznaster J, Rieg S, Prasser F, Pilgram L, Spottke A, Klockgether T, Klein C, Hopfner F, Höglinger GU and the LEOSS Study Group (2021), Outcomes of SARS‐CoV‐2 Infections in Patients With Neurodegenerative Diseases in the LEOSS Cohort. Mov Disord.

Jakob CEM, Kohlmayer F, Meurers T, Vehreschild JJ, Prasser F. Design and evaluation of a data anonymization pipeline to promote Open Science on COVID-19. Scientific Data Volume 7, Article Number: 435 (2020).

Wirth FN, Johns M, Meurers T, Prasser F. Citizen-Centered Mobile Health Apps Collecting Individual-Level Spatial Data for Infectious Disease Management: Scoping Review. JMIR Mhealth Uhealth 2020;8(11):e22594. doi: 10.2196/22594

Spengler, H, Gatz, I, Kohlmayer, F, Kuhn, K A, Prasser, F (2020, July). Improving Data Quality in Medical Research: A Monitoring Architecture for Clinical and Translational Data Warehouses. In 2020 IEEE 33rd International Symposium on Computer-Based Medical Systems (CBMS) (pp. 415-420). IEEE.

Wirth F, Johns M, Meurers T, Prasser F. Anonymisierung medizinischer Daten. digma - Zeitschrift für Datenrecht und Informationssicherheit. 20. Jahrgang, Heft 2, Juni 2020

Spengler H, Lang C, Mahapatra T, Gatz I, Kuhn KA, Prasser F. Enabling Agile Clinical and Translational Data Warehousing: Platform Development and Evaluation. JMIR Med Inform 2020;8(7):e15918

Raisaro JL, Marino F, Troncoso-Pastoriza J, Beau-Lejdstrom R, Bellazzi R, Murphy R, Bernstam EV, Wang H, Bucalo M,  Chen Y, Gottlieb A, Harmanci A, Kim M, Kim Y, Klann J, Klersy C, Bradley A, Malin BA, Méan M, Prasser F, Scudeller L, Torkamani A, Vaucher J, Puppala M, Wong STC, Frenkel-Morgenstern M, Xu H, Maiyaki Musa B, Habib AG, Cohen T,  Wilcox A, M Salihu HM, Sofia H, Jiang X, Hubaux JP. SCOR: A secure international informatics infrastructure to investigate COVID-19. Journal of the American Medical Informatics Association, ocaa172. Published: 10 July 2020

Bild R, Kuhn KA, Prasser F. Better Safe Than Sorry - Implementing Reliable Health Data Anonymization. Stud Health Technol Inform. 2020 Jun 16;270:68-72

Vogelsang L, Lehne M, Schoppmann P, Prasser F, Thun S, Scheuermann B, Schepers J. A Secure Multi-Party Computation Protocol for Time-To-Event Analyses. Stud Health Technol Inform . 2020 Jun 16;270:8-12

Bild R, Eicher J, Prasser F. Efficient Protection of Health Data From Sensitive Attribute Disclosure. Stud Health Technol Inform . 2020 Jun 16;270:193-197

Bild R, Bialke M, Buckow K, Ganslandt T, Ihrig K, Jahns R, Merzweiler A, Roschka S, Schreiweis B, Stäubert S, Zenker S, Prasser F. Towards a comprehensive and interoperable representation of consent-based data usage permissions in the German medical informatics initiative. BMC Medical Informatics and Decision Making. 20 (1), 1-9 (2020)

Eicher J, Bild R, Spengler H, Kuhn KA, Prasser F. A comprehensive tool for creating and evaluating privacy-preserving biomedical prediction models. BMC Medical Informatics and Decision Making. 20 (1), 1-14 (2020)

Prasser F, Eicher J, Spengler H, Bild R, Kuhn KA. Flexible data anonymization using ARX—Current status and challenges ahead. Software: Practice and Experience 2020. 50 (7), 1277-1304

Schaefer J, Lehne M, Schepers J, Prasser F, Thun S. The use of machine learning in rare diseases: a scoping review. Orphanet Journal of Rare Diseases Volume 15, Article number: 145 (2020)

Diese Arbeiten wurde an der TU München, dem ehemaligen Forschungsstandort von Fabian Prasser, durchgeführt.

Prasser F, Spengler H, Bild R, Eicher J, Kuhn KA. Privacy-enhancing ETL-processes for biomedical data. International journal of medical informatics 126, 72-81 (2019)

Spengler H, Prasser F. Protecting Biomedical Data Against Attribute Disclosure. Studies in health technology and informatics 267, 207-214 (2019)

Kohlmayer F, Lautenschläger R, Prasser F. Pseudonymization for research data collection: is the juice worth the squeeze? BMC medical informatics and decision making 19 (1), 178 (2019)

Diese Arbeiten wurde an der TU München, dem ehemaligen Forschungsstandort von Fabian Prasser, durchgeführt.

Prasser F, Kohlbacher O, Mansmann U, Bauer B, Kuhn KA. Data integration for future medicine (DIFUTURE). Methods of information in medicine 57 (S 01), e57-e65 (2018)

Bild R, Kuhn KA, Prasser F. Safepub: A truthful data anonymization algorithm with strong privacy guarantees. Proceedings on Privacy Enhancing Technologies 2018 (1), 67-87 (2018)

Holub P, Kohlmayer F, Prasser F, Mayrhofer MT, Schlünder I, Martin GM, Casati S, Koumakis L, Wutte A, Kozera L, Strapagiel D, Anton G, Zanetti G, Sezerman OU, Mendy M, Valík D, Lavitrano M, Dagher G, Zatloukal K, van Ommen GB, Litton JE. Enhancing Reuse of Data and Biological Material in Medical Research: From FAIR to FAIR-Health. Biopreservation and biobanking 16 (2), 97-105 (2018)

Ganslandt T, Boeker M, Löbe M, Prasser F, Schepers J, Semler SC, Thun S, Sax U. Der Kerndatensatz der Medizininformatik-Initiative: Ein Schritt zur Sekundärnutzung von Versorgungsdaten auf nationaler Ebene. Forum der Medizin-Dokumentation und Medizin-Informatik 20 (1), 17 (2018)

Bietenbeck A, Prasser F. Learning Health Systems and Laboratory Medicine. GMDS, 104-108 (2018)

Diese Arbeiten wurde an der TU München, dem ehemaligen Forschungsstandort von Fabian Prasser, durchgeführt.

Prasser F, Kohlmayer F, Spengler H, Kuhn KA. A scalable and pragmatic method for the safe sharing of high-quality health data. IEEE journal of biomedical and health informatics 22 (2), 611-622 (2017)

Prasser F, Eicher J, Bild R, Spengler H, Kuhn KA. A tool for optimizing de-identified health data for use in statistical classification. 2017 IEEE 30th International Symposium on Computer-Based Medical Systems (CBMS)

Eicher J, Kuhn KA, Prasser F. An Experimental Comparison of Quality Models for Health Data De-Identification. Studies in health technology and informatics 245, 704-708 (2017)

Prasser F, Gaupp J, Wan Z, Xia W, Vorobeychik Y, Kantarcioglu M, Kuhn K, Malin B. An open source tool for game theoretic health data de-identification. AMIA Annual Symposium Proceedings 2017, 1430 (2017)

Diese Arbeiten wurde an der TU München, dem ehemaligen Forschungsstandort von Fabian Prasser, durchgeführt.

Prasser F, Bild R, Eicher J, Spengler H, Kohlmayer F, Kuhn KA. Lightning: Utility-Driven Anonymization of High-Dimensional Data. Transactions on Data Privacy 9 (2), 161-185 (2016)

Prasser F, Kohlmayer F, Kuhn KA. The importance of context: Risk-based de-identification of biomedical data. Methods of information in medicine 55 (04), 347-355 (2016)

Prasser F, Kohlmayer F, Kuhn KA. Efficient and effective pruning strategies for health data de-identification. BMC medical informatics and decision making 16 (1), 49 (2016)

Prasser F, Bild R, Kuhn KA. A Generic Method for Assessing the Quality of De-Identified Health Data. MIE, 312-316 (2016)

Diese Arbeiten wurde an der TU München, dem ehemaligen Forschungsstandort von Fabian Prasser, durchgeführt.

Prasser F, Kohlmayer F. Putting statistical disclosure control into practice: The ARX data anonymization tool. Medical Data Privacy Handbook, 111-148 (2015)

Kohlmayer F, Prasser F, Kuhn KA. The cost of quality: Implementing generalization and suppression for anonymizing biomedical data with minimal information loss. Journal of biomedical informatics 58, 37-48 (2015)

Lautenschläger R, Kohlmayer F, Prasser F, Kuhn KA. A generic solution for web-based management of pseudonymized data. BMC Medical Informatics and Decision Making 15 (1), 100 (2015)

Diese Arbeiten wurde an der TU München, dem ehemaligen Forschungsstandort von Fabian Prasser, durchgeführt.

Prasser F, Kohlmayer F, Lautenschlaeger R, Kuhn KA. ARX – A Comprehensive Tool for Anonymizing Biomedical Data. Proceedings of the 2014 AMIA Annual Symposium, 2014:984-993

Kohlmayer F, Prasser F, Eckert C, Kuhn KA. A flexible approach to distributed data anonymization. Journal of biomedical informatics 50, 62-76 (2014)

Prasser F, Kohlmayer F, Kuhn KA. A Benchmark of Globally-Optimal Anonymization Methods for Biomedical Data. Proceedings of the IEEE 27th International Symposium on Computer-Based Medical Systems. 27-29 May 2014

Diese Arbeiten wurde an der TU München, dem ehemaligen Forschungsstandort von Fabian Prasser, durchgeführt.

Prasser F. Incremental Ontology-Based Integration for Translational Medical Research. Dissertation, Technical University of Munich (2013)

Diese Arbeiten wurde an der TU München, dem ehemaligen Forschungsstandort von Fabian Prasser, durchgeführt.

Kohlmayer F, Prasser F, Eckert C, Kemper A, Kuhn KA. Flash: efficient, stable and optimal k-Anonymity. 2012 International Conference on Privacy, Security, Risk and Trust and 2012 International Confernece on Social Computing. 3-5 Sept 2012

Prasser F, Kemper A, Kuhn KA. Efficient distributed query processing for autonomous RDF databases. Proceedings of the 15th International Conference on Extending Database Technology. March 2012, Pages 372–383

Kohlmayer F, Prasser F, Eckert C, Kemper A, Kuhn KA. Highly efficient optimal k-Anonymity for biomedical datasets. 2012 25th IEEE International Symposium on Computer-Based Medical Systems (CBMS). 20-22 June 2012

Prasser F, Kohlmayer F, Kemper A, Kuhn KA. A Generic Transformation of HL7 Messages into the Resource Description Framework Data Model. GI-Edition: Lecture Notes in Informatics 208, 1559-1564 (2012)

Schleinkofer T, Villain S, Lamla G, Prasser F, Kuhn KA, Mansmann U. S3U LMU–Prototyp-Infrastruktur für die IT-Unterstützung klinischer Studien am Klinikum der Universität München. GI-Edition: Lecture Notes in Informatics 208, 1260-1274 (2012)

Diese Arbeiten wurde an der TU München, dem ehemaligen Forschungsstandort von Fabian Prasser, durchgeführt.

Prasser F, Wurst SHR, Lamla G, Kohlmayer F, Blaser R, Schmelcher D, Vögele B, Kuhn KA. Informatics and Translational Medical Research: Challenges and Developments. it - Information Technology 53 (5), 217-226 (2011)

Diese Arbeiten wurde an der TU München, dem ehemaligen Forschungsstandort von Fabian Prasser, durchgeführt.

Wurst SHR, Lamla G, Schmelcher D, Prasser F, Kuhn KA. IT-Unterstützung Translationaler Forschung im Rahmen der Clinical and Translational Science Awards. GI-Edition: Lecture Notes in Informatics 175, 786-789 (2010)

Prasser F, Wurst SHR, Lamla G, Kuhn KA, Kemper A. Inkrementelle ontologiebasierte Informationsintegration für die translationale medizinische Forschung. GI-Edition: Lecture Notes in Informatics 192, 157 (2010)

Lamla G, Blaser R, Prasser F, Wurst SHR, Rechl H, Gradinger R, Kuhn KA. Eine Umsetzung des IHE Single Source Konzepts für die translationale Forschung bei Knochen-und Weichteilsarkomen. GI-Edition: Lecture Notes in Informatics 176, 739-745 (2010)

Diese Arbeiten wurde an der TU München, dem ehemaligen Forschungsstandort von Fabian Prasser, durchgeführt.

Wurst SHR, Lamla G, Prasser F, Kemper A, Kuhn KA. Einsatz von Dataspaces für die inkrementelle Informationsintegration in der Medizin. GI-Edition: Lecture Notes in Informatics 154, 709-715 (2009)